CUSHING'S DISEASE

Question 1

WHAT IS CUSHING’ S DISEASE?

Answer 1

• hypercortisolism

Question 2

WHAT ARE THE SIGNS OF CUSHING’S DISEASE?

Answer 2

1) Central obesity
2) Dorso-cerivcal fat pad (Buffalo hump)
3) Increased roundness of face
4) Red face (plethora)
5) Thin skin
6) Easy bruising
7) Proximal myopathy (symmetrical weakness of proximal upper and lower limbs)

Question 3

WHAT ARE THE SYMPTOMS OF CUSHING’S DISEASE?

Answer 3

1) Hypertension
2) Premature osteoporosis
3) Diabetes mellitus

Question 4

WHAT TWO CLINICAL CONDITIONS CAN CAUSE PATIENTS TO LOOK CUSHINGOID DESPITE A NORMAL SCREENING TEST?

Answer 4

1) Severe depression

2) Alcoholism

Question 5

WHAT IS THE DIFFERENTIAL DIAGNOSIS FOR CUSHING’S DISEASE?

Answer 5

1) Metabolic syndrome - central obesity with insulin resistance and hypertension

Question 6

WHAT IS THE TREATMENT FOR CUSHINGS DISEASE DUE TO AN ADRENAL TUMOUR ?

Answer 6

Laparoscopic adrenalectomy