Cumulative Final - Hematology (Grove)

Question 1

What is unique about the lymph system in cancer?

Answer 1

It runs throughout the entire body, so we have to give systemic medications; no such thing as metastatic

Question 2

What is lymphoma?

Answer 2

Solid tumors of the immune system

Question 3

What is the difference between non-hodgkin lymphoma and hodgkin lymphoma?

Answer 3

Hodgkin lymphoma characterized by Reed-Sternberg cells!

Question 4

HL presentation (hallmark)

Answer 4

B symptoms (fever greater than 38 Celsius, drenching sweats, unintentional weight loss > 10% in a maximum of 6 months)

Question 5

HL patients are (younger/older) and NHL patients are (younger/older)

Answer 5

Younger
Older

Question 6

One of the main infections for NHL

Answer 6

EBV

Question 7

R-CHOP toxicities

Answer 7

Neutropenia and febrile neutropenia

Question 8

Tx for R-CHOP toxicities

Answer 8

Growth factors

Question 9

Prior to giving a patient Rituximab, check if they were previously infected with _______

Answer 9

Hepatitis B bc increased risk of re-activating

Question 10

Treat positive HepB pts going to get rituximab pre-emptively with ______

Answer 10

entecavir

Question 11

Tx for anti-CD20 antibody late neutropenia

Answer 11

Give G-CSF; if that doesn’t respond, give immunoglobulins (growth factors)

Question 12

BiTE and CAR-T cell unique toxicities

Answer 12

Cytokine release syndrome (CRS) and Immune effector cell-associated neurotoxicity syndrome (ICANS)

Question 13

Tx for cytokine release syndrome from BiTE and CAR-T

Answer 13

Tocilizumab
CCS
Supportive Care

Question 14

Tx for ICANS from BiTE and CAR-T

Answer 14

CCS

Question 15

Increased risk of ____ with proteasome inhibitor or monoclonal antibodies

Answer 15

Herpes

Question 16

Prophylaxis for proteasome inhibitor/mAB to prevent Herpes

Answer 16

Acyclovir or Valacyclovir

Question 17

Tx for thromboembolic risk for IMiD/Dexamethasone

Answer 17

Enoxaparin
ASA
Warfarin

Question 18

TKI clinical pearl

Answer 18

CANNOT MISS A DOSE

Question 19

Imatinib ADR

Answer 19

Nausea

Question 20

Dasatinib ADR

Answer 20

Fluid retention (pleural effusion)

Question 21

Nilotinib ADR

Answer 21

QTc interval prolongation
Metabolic syndrome

Question 22

Bosutinib ADR

Answer 22

Diarrhea
GI/hepatotoxicity

Question 23

Ponatinib ADR

Answer 23

Ischemic reactions
Vascular occlusion
HTN

Question 24

_____ has the highest risk for AFib

Answer 24

Ibrutinib

Question 25

Venetoclax toxicity

Answer 25

Tumor lysis syndrome (TLS)–ramp up dosing

Question 26

Anthracycline toxicity (-rubicin)

Answer 26

Cardiotoxicity
Mucositis
Nausea

Question 27

Cytarabine toxicity

Answer 27

Myelosuppression
Nausea
Chemical conjunctivitis (gritty feeling in eye)

Question 28

SE of stem cell transplant

Answer 28

Graft vs host disease
Liver toxicity = sinusoidal obstructive syndrome

Question 29

Blinatumomab toxicities

Answer 29

Cytokine release syndrome
ICANS
Neurotoxicity

Question 30

Asparaginase toxicity

Answer 30

Anaphylaxis
Hypertriglyceridemia

Question 31

Vincristine toxicity

Answer 31

Neurotoxicity

Question 32

Doxorubicin toxicity

Answer 32

Cardiac toxicity

Question 33

Tx to prevent doxorubicin cardiac toxicity

Answer 33

Give dexrazoxane

Question 34

Vinblastine toxicity

Answer 34

Thrombocytopenia

Question 35

Brentuximab + Vinblastine toxicity

Answer 35

Peripheral neuropathy
Febrile neutropenia

Question 36

BiTES toxicity

Answer 36

Proinflammatory cytokine release
ICANS

Question 37

Tx for BiTES toxicity

Answer 37

Steroids
IL-2 inhibitors

Question 38

Gilteritinib toxicity

Answer 38

Myelosuppression
Febrile neutropenia
Hepatotoxicity
GI issues

Question 39

Tx for blinatumomab toxicity

Answer 39

Steroids
Chemo

Question 40

All trans retinoic acid (ATRA) toxicity

Answer 40

Differentiation syndrome (blood clot)

Question 41

Arsenic trioxide toxicity

Answer 41

Temporary QT prolongation