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P3 > CUDs > Flashcards

CUDs Flashcards

1
Q

Baclofen

A

Lioresal® (skeletal muscle relaxant)

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2
Q

carisoprodol

A

Soma® (skeletal muscle relaxant)

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3
Q

cyclobenzaprine

A

Flexeril® (skeletal muscle relaxant)

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4
Q

methocarbamol

A

Robaxin® (skeletal muscle relaxant)

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5
Q

tizanidine

A

Zanaflex® (alpha 2 adrenergic agonist)

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6
Q

fentanyl

A

Duragesic® (analgesic/opioid)

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7
Q

tramadol

A

Ultram® (analgesic/opioid)

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8
Q

methadone

A

Dolophine® (analgesic/opioid)

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9
Q

oxycodone

A

OxyContin® (analgesic/opioid)

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10
Q

codeine/ acetaminophen

A

Tylenol® #3, Tylenol® #4 (combo analgesic)

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11
Q

oxycodone/ APAP

A

Percocet® (combo analgesic)

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12
Q

Buprenorphine + Naloxone

A

Suboxone® (Analgesic, Opioid & Opioid Antagonist)

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13
Q

gabapentin

A

Neurontin® (anticonvulsant)

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14
Q

lamotrigine

A

Lamictal® (anticonvulsant)

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15
Q

Levetiracetam

A

Keppra® (anticonvulsant)

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16
Q

Divalproex

A

Depakote® (anticonvulsant)

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17
Q

Phenytoin

A

Dilantin® (anticonvulsant)

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18
Q

Pregabalin

A

Lyrica® (anticonvulsant)

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19
Q

Topiramate

A

Topamax® (anticonvulsant)

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20
Q

Glipizide

A

Glucotrol® (sulfonylurea)

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21
Q

Glyburide

A

Diabeta® (sulfonylurea)

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22
Q

Nitrofurantoin

A

Macrobid® (nitrofuran antibiotic)

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23
Q

Valacyclovir

A

Valtrex® (Antiviral Agent, DNA polymerase inhibitor)

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24
Q

Ropinirole

A

Requip® (dopamine agonist)

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25
Q

Rivastigmine

A

Exelon® (Acetylcholinesterase Inhibitor)

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26
Q

Memantine

A

Namenda® (N-Methyl-D-Aspartate (NMDA)Receptor Antagonist)

27
Q

Sumatriptan

A

Imitrex® (Serotonin 5-HT1B, 1D Receptor Agonist)

28
Q

Raloxifene

A

Evista® (Selective Estrogen Receptor Modulator (SERM))

29
Q

Baclofen MoA

A

Inhibits the transmission of both monosynaptic and polysynaptic reflexes at the spinal cord level, possibly by hyperpolarization of primary afferent fiber terminals, with resultant relief of muscle spasticity

30
Q

Baclofen ADR

A

CNS: Hypotonia, drowsiness, confusion, somnolence
GI: Nausea

31
Q

Baclofen major interaction

A

CNS depressants

32
Q

Carisoprodol MoA

A

Blocks interneuronal activity and depresses polysynaptic neuron transmission in the spinal cord and reticular formation of the brain

33
Q

Carisoprodol ADR

A

CNS: Drowsiness, dizziness

34
Q

Carisoprodol major interaction

A

CYP2C19 inhibitors and inducers, CNS depressants

35
Q

Cyclobenzaprine MoA

A

Centrally-acting skeletal muscle relaxant, reduces tonic somatic motor activity influencing both alpha and gamma motor neurons

36
Q

cyclobenzaprine ADR

A

CNS: Drowsiness, dizziness
GI: Xerostomia

37
Q

cyclobenzaprine major interaction

A

CNS Depressants, Anticholinergic drugs

38
Q

Methocarbamol MoA

A

Causes skeletal muscle relaxation by general CNS depression

39
Q

Methocarbamol ADR

A

“CNS: Somnolence

Cardiovascular: Bradycardia (rare)”

40
Q

Methocarbamol major interaction

A

CNS Depressants

41
Q

Tizanidine MoA

A

Centrally acting muscle relaxant that is an alpha2-adrenergic agonist agent which decreases spasticity by increasing presynaptic inhibition

42
Q

Tizanidine ADR

A

“CNS: drowsiness, dizziness
Musculoskeletal: asthenia, muscle weakness
GI: xerostomia
Cardiovascular: hypotension”

43
Q

Tizanidine major interaction

A

CNS depressants, CYP1A2 substrates

44
Q

Fentanyl MoA

A

Mu opioid receptor agnonist

45
Q

Fentanyl ADR

A

“Black box warning (BBW): Life-threatening respiratory depression; addiction, absue and misuse; neonatal opioid withdrawal syndrome
GI: constipation
CNS: dizziness, drowsiness, confusion, fatigue, sedation”

46
Q

Fentanyl major interactions

A

CYP3A4 inducers/inhibitors, CNS depressants, Benzodiazepines

47
Q

Tramadol MoA

A

Mu opioid receptor agonist and weak inhibitor of serotonin and norepinephrine reuptake

48
Q

Tramadol ADR

A

“BBW: Life-threatening respiratory depression; addiction, absue and misuse; neonatal opioid withdrawal syndrome
GI: constipation
CNS: dizziness, drowsiness, confusion, fatigue, sedation”

49
Q

Tramadol major interaction

A

CYP2D6 and CYP3A4 inhibitors and inducers, CNS depressants, Benzodiazepines

50
Q

Methadone MoA

A

Mu opioid receptor agonist and N-methyl-D-aspartate (NMDA) receptor antagonist

51
Q

Methadone ADR

A

“BBW: life-threatening respiratory depression, addiction, absue and misuse, life-threatening QTc prolongation; neonatal opioid withdrawal syndrome
GI: constipation
CNS: dizziness, drowsiness, sedation
Cardiovascular: hypotension, QTc prolongation “

52
Q

Methadone major interactions

A

QTc prolonging drugs, CYP2B6 and CYP3A4 inhibitors and inducers, CNS depressants, Benzodiazepines, Monoamine oxidase inhibitors (MAOIs), Serotonergic drugs (tricyclic antidepressants, selective serotonin reuptake inhibitors)

53
Q

Oxycodone MoA

A

Mu opioid receptor agonist

54
Q

Oxycodone ADR

A

“BBW: Life-threatening respiratory depression; addiction, absue and misuse; neonatal opioid withdrawal syndrome
GI: constipation
CNS: dizziness, drowsiness, confusion, fatigue, sedation
Derm: pruritis “

55
Q

Oxycodone major interaction

A

CYP3A4 inducers/inhibitors, CNS depressants, Benzodiazepines

56
Q

Codeine / Acetaminophen MoA

A

“Acetaminophen: activation of descending serotonergic inhibitory pathways in the CNS
Codeine: mu opioid receptor agonist “

57
Q

Codeine / Acetaminophen ADR

A

“BBW: life-threatening respiratory depression; addiction, absue and misuse; neonatal opioid withdrawal syndrome; hepatotoxcity; ultra rapid metabolism of codeine in children
GI: constipation
CNS: dizziness, headache, drowsiness;
Dermatologic: pruritus”

58
Q

Codeine / Acetaminophen major interaction

A

CYP2D6 inhibitors and inducers, CNS depressants, Benzodiazepines

59
Q

Oxycodone/APAP MoA

A

“Acetaminophen: activation of descending serotonergic inhibitory pathways in the CNS
Oxycodone: mu opioid receptor agonist “

60
Q

Oxycodone/APAP ADR

A

“BBW: life-threatening respiratory depression; addiction, absue and misuse; neonatal opioid withdrawal syndrome; hepatotoxcity
GI: constipation
CNS: dizziness, headache, drowsiness;
Dermatologic: pruritus”

61
Q

Oxycodone/APAP major interactions

A

CYP3A4 inducers/inhibitors, CNS depressants, Benzodiazepines

62
Q

Buprenorphine + Naloxone MoA

A

“Buprenorphine: mu opioid receptor partial agonist and weak kappa opioid receptor antagonist
Naloxone: mu opioid receptor antagonist “

63
Q

Buprenorphine + Naloxone ADR

A

“CNS: headache, pain, insomnia, opioid withdrawal, dizziness
Dermatologic: sweating
GI: nausea, constipation, abdominal pain, liver impairment (rare)
Cardiology: vasodilation “

64
Q

Buprenorphine + Naloxone major interactions

A

CNS depressants, CYP3A4 inhibitors/inducers, Benzodiazepines, Opioid antagonists/agonists

P3 (2 decks)

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