CT Flashcards
Quantifies CAC as a function of CAC surface area and density.
Agatston score
In some studies a CAC score of more than 300 or greater has been used as an alrernative threahold to described severely elevated CAC level
MACE rate over 4 years for CAC score of Zero
0.5%
MACE rate for CAC score > 400
10%
Study which demostrates the prognostic value of CAC across many cohorts worldwide
MESA or multi-ethnic study of atherosclerosis
According to MESA study, higher CAC were noted in the ff
Caucasians and Hispanics, male sex and advancing age
A population based cohort study that showed upper quartile CAC had an event rate 11.1 times that of lowest quartile in men and 3.2 times in women
Heinz-Nixdorf Recall study
The ff are true of CAC except
> atherosclerotic burden
independent predictor Cerebrovascular Risk
associated with future adverse clinical events, AF, cancer stroke and CHF
None of the above
RCT on atorvastatin + vit c + vit E compared to placebo showed no difference in the composite CV endpoints
St. Francis Heart Study
This study demonstrated the highest diagnostic accuracy with Sn of 91% and Sp of 92% comparing with PET, Stress echo and CMR
EVINCI study or Evaluation of Integrated Cardiac Imaging in Ischemic Heart Disease
The largest study evaluating the prognostic value of CAD findings on CCTA (2.6x increased risk of death for stenosis > 70%, increasing risk of mortality with greater # of coronary distribution, women > men greater risk of mortality, low all cause-death in thr absence of CAD by ccta)
CONFIRM study or Coronary CT Angiography Evaluation of Clinical Outcomes: an International Multicenter Registry)
Hounsfield unit cutoff point for calcified plaque
130 HU
Hounsfield unit cutoff point for lipoid plaques
< 70 HU
Hounsfield unit cutoff point for fibrous plaque
70-130 HU
Hounsfield unit cutoff point for vulnerable plaque
< 30 HU
Defined as distinct calcifications < 3mm in length circumscribing a 90 degree or less arc in cross section
Spotty calcifications