CT 4.2 Breast Flashcards

1
Q

how can breast cancer be classified as

A

ductal carcinoma

lobular carcinoma

can be in-situ or invasive

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2
Q

what is the most common type of breast cancer

A

invasive ductal carcinoma

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3
Q

what are the other more rarer forms of breast cancer

A

medullary breast cancer
papillary breast cancer
mucinous breast cancer
tubular breast cancer
adenoid cystic breast cancer
metaplastic breast cancer
lymphoma of the breast
basal type breast cancer
phyllodes
inflammatory breast cancer (presents similarly to breast abscess or mastitis)

pagets disease of the nipple: looks like eczema of the nipple but instead this starts from the nipple and spreads to areola

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4
Q

what hormonal receptors can be targeted on BC cells

A

oestrogen receptors
progesterone receptors
human epidermal growth factors HER2

triple negative cancer cells lack any of the above making it more difficult to teat

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5
Q

signs and symptoms of breast cancer

A

lump (irregular, hard, painless or painful, immobile)

nipple retraction
discharge
skin dimpling
lymphadenopathy

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6
Q

what are the risk factors for getting BC

A
  • Female (99% of breast cancers)
    Increased oestrogen exposure (earlier onset of periods and later menopause)
    More dense breast tissue (more glandular tissue)
    Obesity
    Smoking
    Family history (first-degree relatives)
    BRCA1 BRCA2
    nulliparity
    oral combined and HRT
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7
Q

what counts as family history for breast cancer

A

breast cancer in a first degree male of any age
breast cancer in a first degree under age of 40
bilateral breast cancer in first degree relative under age of 50
breast cancer in two first degree relatives

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8
Q

what is breast screening like

A

offers a mammogram (X-ray) every 3 years to women between the ages of 50 and 70

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9
Q

what investigations are carried out

A

mammogram
ultrasound
MRI in high risk patients
biopsy (fine needle or core)
genetic testing if +ve FHx

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10
Q

cons of mammography

A

low sensitivity
low specificity
pain
cannot distinguish between all types of breast cancer

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11
Q

what is the protocol if patients have palpable axillary lymphadenopathy

A

axillary node removal
may lead to lymphedema and functional arm impairment

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12
Q

what is the protocol if patients have no palpable axillary lymphadenopathy

A

pre-operative ultrasound axillary ultrasound before surgery
sentinel node biopsy

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13
Q

what are the two surgical choices for BC

A

wide local excision <4cm

mastectomy

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14
Q

what is given after wide local excision

A

whole breast radiotherapy

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15
Q

for tumours that are oestrogen sensitive what is given to them

A

for pre and peri menopausal women tamoxifen is given (oestrogen receptor antagonist)

for post menopausal women aromatase inhibitors are given = anastrazole

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16
Q

what is given to HER2 sensitive patients

A

herceptin

is a monoclonal antibody

cannot be used in patients with existing heart disease

17
Q

what chemo regime can be given before or after surgery in BC

A

FEC-D

5 fluorouracil
epirubucin
cyclophosphamide
docetaxel

18
Q

where does BC spread to

A
  • lungs
  • liver
  • bones
  • brain
19
Q

what is the non surgical treatment for lymphedema

A

decongestive lymphatic therapy:
1) manual drainage ie massage
2) compression bandages
3) specific exercises
4) good skin care

20
Q

what is the surgical treatment for severe lymphedema

A

removal of sections of excess skin
and underlying tissue (debulking), removal of fat from the affected limb (liposuction), and restoration
of the flow of fluid around the affected area of the lymphatic system (lymphaticovenular anastomosis
(LVA), where the lymphatic system is connected to nearby blood vessels)

21
Q

presentation of mastitis

A

unilateral painful, tender, red hot breast, and there can be fever and general malaise

22
Q

management of mastitis

A

continue breastfeeding as normal, with analgesia and warm compresses

oral fluclox 10-14 days

23
Q

epidemiology of BC

A

Breast cancer is the most common cancer in females, affecting 1 in 8 women (only contributes to 1%
of cancers affecting men). There are around 60,000 cases in the UK every year. Incidence is
increasing due to more efficient screening programmes, and a greater awareness

24
Q

principles of effective screening programme

A

cost-effective, the condition must be an important health problem, the condition should have a recognisable latent phase, the natural history
of the condition should be understood, there should be an effective form of treatment available, and
the screening technique must be highly accurate, acceptable to patients, and have facilities available

25
Identify the psychosocial impact on patients and their families of the diagnosis and treatment of breast and other cancers and outline the importance of socio cultural background in determining the psychosocial response to diagnosis and treatment (H&S)
Certain factors that can influence a patient’s response to cancer diagnosis include their coping mechanisms, support networks, hobbies, their character, and whether they’re independent or rely on family members. Culture and religion is also a factor in the resilience of a person, and can be seen as a coping mechanism * * * The dual process model to grief states we cope with grief by carrying out loss-orientated behaviours (e.g. grief, breaking ties with people, denial, avoidance etc - usual stuff with grief) and restoration-orientated behaviours (e.g. doing new things, new roles, new relationships - stuff that helps you get over it), with both sides being important Effects grief can have on patients is implications on work and childcare, anxiety about health and wellbeing, social isolation and depression, and impacts on relationships with friends and family. Furthermore, side effects of cancer and its treatment like weight loss/anorexia, fatigue, hair loss etc can impact the patient’s personal image Effects grief can have on families is the increased burden on travel and care for their family member, impact mentally with stress, anxiety and emotions, and stress on the relationship with the patient
26
Describe the factors that are associated with delayed presentation of breast symptoms in primary care (H&S)
There are 3 phases in which delayed diagnosis can occur: ◦ Patient delay = interval between the patient first noticing symptoms and first consulting a doctor. Things that affect this are older age, socioeconomic status, education level, being of non-white ethnic origin, awareness and interpretation of symptoms, a ‘wait and see’ approach (i.e. denial, self-diagnosis, self-medication), fear of cancer diagnosis and further investigation and treatment, and a lack of social support ◦ Practitioner delay = time between the first consultation and referral to breast clinic. Generally younger aged and male patients aren’t referred as quickly, due to reduced likelihood of cancer diagnosis. Also, presentation of symptoms other than a breast lump cause delay in referral due to non-specificity of symptoms ◦ System delay = time between referral and diagnosis. Things that can affect this include misdiagnosis, just treating patients symptomatically, failure to adequately examine patients, and inappropriate requests
27
what is a fibroadenoma
Develop from a whole lobule Mobile, firm breast lumps 12% of all breast masses Over a 2 year period up to 30% will get smaller No increase in risk of malignancy
28
what is a breast cyst
7% of all Western females will present with a breast cyst Usually presents as a smooth discrete lump (may be fluctuant) Small increased risk of breast cancer (especially if younger)
29
what are the benign causes of a breast lump
Fibroadenoma – A common, firm, mobile, and painless lump seen in younger women. fibroadenosis/Fibrocystic Changes – Lumpy, tender breasts that fluctuate with the menstrual cycle. Breast Cysts – Fluid-filled sacs that may be tender and fluctuate in size. Lipoma – A soft, movable lump composed of fatty tissue. Intraductal Papilloma – A small, wart-like growth in a milk duct, sometimes causing discharge. Abscess or Mastitis – Infection leading to a painful, red, and swollen lump, more common in breastfeeding women. Fat Necrosis – A firm lump that may develop after breast trauma or surgery.
30
what are the malignant causes of a breast lump
Invasive Ductal Carcinoma (IDC) – The most common type of breast cancer, often presenting as a hard, irregular lump. Invasive Lobular Carcinoma (ILC) – May present as thickening rather than a distinct lump. Inflammatory Breast Cancer (IBC) – Rare but aggressive, presenting with redness, swelling, and peau d’orange appearance.