CT 4.2 Breast Flashcards
how can breast cancer be classified as
ductal carcinoma
lobular carcinoma
can be in-situ or invasive
what is the most common type of breast cancer
invasive ductal carcinoma
what are the other more rarer forms of breast cancer
medullary breast cancer
papillary breast cancer
mucinous breast cancer
tubular breast cancer
adenoid cystic breast cancer
metaplastic breast cancer
lymphoma of the breast
basal type breast cancer
phyllodes
inflammatory breast cancer (presents similarly to breast abscess or mastitis)
pagets disease of the nipple: looks like eczema of the nipple but instead this starts from the nipple and spreads to areola
what hormonal receptors can be targeted on BC cells
oestrogen receptors
progesterone receptors
human epidermal growth factors HER2
triple negative cancer cells lack any of the above making it more difficult to teat
signs and symptoms of breast cancer
lump (irregular, hard, painless or painful, immobile)
nipple retraction
discharge
skin dimpling
lymphadenopathy
what are the risk factors for getting BC
- Female (99% of breast cancers)
Increased oestrogen exposure (earlier onset of periods and later menopause)
More dense breast tissue (more glandular tissue)
Obesity
Smoking
Family history (first-degree relatives)
BRCA1 BRCA2
nulliparity
oral combined and HRT
what counts as family history for breast cancer
breast cancer in a first degree male of any age
breast cancer in a first degree under age of 40
bilateral breast cancer in first degree relative under age of 50
breast cancer in two first degree relatives
what is breast screening like
offers a mammogram (X-ray) every 3 years to women between the ages of 50 and 70
what investigations are carried out
mammogram
ultrasound
MRI in high risk patients
biopsy (fine needle or core)
genetic testing if +ve FHx
cons of mammography
low sensitivity
low specificity
pain
cannot distinguish between all types of breast cancer
what is the protocol if patients have palpable axillary lymphadenopathy
axillary node removal
may lead to lymphedema and functional arm impairment
what is the protocol if patients have no palpable axillary lymphadenopathy
pre-operative ultrasound axillary ultrasound before surgery
sentinel node biopsy
what are the two surgical choices for BC
wide local excision <4cm
mastectomy
what is given after wide local excision
whole breast radiotherapy
for tumours that are oestrogen sensitive what is given to them
for pre and peri menopausal women tamoxifen is given (oestrogen receptor antagonist)
for post menopausal women aromatase inhibitors are given = anastrazole
what is given to HER2 sensitive patients
herceptin
is a monoclonal antibody
cannot be used in patients with existing heart disease
what chemo regime can be given before or after surgery in BC
FEC-D
5 fluorouracil
epirubucin
cyclophosphamide
docetaxel
where does BC spread to
- lungs
- liver
- bones
- brain
what is the non surgical treatment for lymphedema
decongestive lymphatic therapy:
1) manual drainage ie massage
2) compression bandages
3) specific exercises
4) good skin care
what is the surgical treatment for severe lymphedema
removal of sections of excess skin
and underlying tissue (debulking), removal of fat from the affected limb (liposuction), and restoration
of the flow of fluid around the affected area of the lymphatic system (lymphaticovenular anastomosis
(LVA), where the lymphatic system is connected to nearby blood vessels)
presentation of mastitis
unilateral painful, tender, red hot breast, and there can be fever and general malaise
management of mastitis
continue breastfeeding as normal, with analgesia and warm compresses
oral fluclox 10-14 days
epidemiology of BC
Breast cancer is the most common cancer in females, affecting 1 in 8 women (only contributes to 1%
of cancers affecting men). There are around 60,000 cases in the UK every year. Incidence is
increasing due to more efficient screening programmes, and a greater awareness
principles of effective screening programme
cost-effective, the condition must be an important health problem, the condition should have a recognisable latent phase, the natural history
of the condition should be understood, there should be an effective form of treatment available, and
the screening technique must be highly accurate, acceptable to patients, and have facilities available