CSIM 1.38 Sexually Transmitted Diseases including HPV Flashcards

1
Q

What STIs have no cures?

A

Viral STIs:
• HIV
• HSV
• HPV

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2
Q

Which bacterium is responsible for:

1) Chlamydia
2) Gonorrhoea
3) Syphilis

A

1) C. trachomatis
2) N. gonorrhoea
3) T. pallidum

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3
Q

What discharge is seen in gonorrhoea?

A

Mucopurulent discharge (mucus and puss)

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4
Q

What lesion is seen in syphilis?

Is it painful?

A

Chancre

Painless

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5
Q

What is the most common bacterial STI in the UK? How can it be transmitted?

A

Chlamydia trachomatis

  • Unprotected oral, vaginal or anal sex
  • Vertically
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6
Q

Describe Chlamydia trachomatis

A
  • Intracellular parasite
    • Gram negative
    • Cocci
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7
Q

What are the serotypes of chlamydia and what does each cause?

A

A-C:
• Granular conjunctivitis

D-K - Azithromycin (1g dose) or Doxycycline BD 7 days
• Pelvic inflammatory disease
• Urethritis
• Ectopic pregnancy
• Neonatal conjunctivitis and pneumonia

L - Doxycycline or ERYthromycin
• Lymphogranuloma
> Fibrosis and blockage of the regional lymphatic system
> Swollen ulcerated inguinal lymph node

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8
Q

What proportion of men and women with chlamydia are asymptomatic?

A

80% of women

50% of men

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9
Q

What are the male symptoms of chlamydia?

A
  • Nongonococcal urethritis
    • If this isn’t treated, this can lead to epididymitis
    • Proctitis
    • Conjunctivitis
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10
Q

What are the female symptoms of chlamydia?

A
  • Cervicitis
    • Vaginal discharge
    • Endometritis (and endometrium goes up to fallopian tubes where it shouldn’t be) - this can cause ectopic pregnancy
    • Proctitis
    • Salpingitis
    • Conjunctivitis
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11
Q

How is chlamydia identified?

A

PCR primers

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12
Q

What is the second most common bacterial STI in the UK?

A

Niesseria gonorrhoea

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13
Q

Describe the Neisseria gonorrhoea bacterium

A
  • Gram negative

* Aerobic diplococci

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14
Q

What proportion of men and women are asymptomatic? (gonorrhoea)

A

50% of women

5% of men

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15
Q

What symptoms can result from mother-to-baby transmission of Niesseria gonorrhoea?

A

Opthalmia neonatorum

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16
Q

What are the male clinical manifestations of gonorrhoea?

A
  • Urethritis
    • Dysuria
    • Asymptomatic rectal infection
    • Asymptomatic pharyngeal infection
17
Q

What are the female clinical manifestations of gonorrhoea?

A
  • Endocervical infection (abnormal vaginal discharge 50%, asymptomatic 50%)
    • Pelvic inflammatory disease
18
Q

What is the treatment for gonorrhoea?

A

ceftriaxone AND azithromycin

19
Q

Which STI causes conjunctivitis?

A

Chlamydia

Gonorrhoea (VERTICAL NEONATAL ONLY)

20
Q

Describe Treponema pallidum (syphilis) bacterium

A
  • Neither gram negative or positive (too thin for staining)

* Spirochete

21
Q

What are the clinical manifestations of syphilis?

A

Stage 1:
• Chancre
• Heals without treatment

Stage 2:
• Maculopapular rash 6 weeks after the primary (chancre) lesion
• Condylomata lata in anogenital region
• Heals without treatment

Stage 3 (40% reach this stage):
• Dementia and paralysis (neurosyphilis)
• Gummata
• Stroke & heart disease

22
Q

What can untreated congenital syphilis lead to?

A
  • Stage 2 symptoms

* Schemata: CNS and developmental abnormalities (particularly in teeth and bones)

23
Q

Describe the pappilomaviruses virology

A
  • 170 serotypes
    • DNA
    • Non-enveloped
24
Q

Which papillomavirus serotypes infect/cause:

1) Anogenital tract
2) Condylomata acuminata
3) Malignant lesions
4) Plantar and facial warts
5) Warts on knees and fingers

A

1) 6, 11, 16, 18
2) 6, 11
3) 16, 18
4) 1, 4
5) 2, 3, 10

25
Q

What is condylomata acuminata?

A

Genital wart, caused by HPV 6 & 11

26
Q

What dysplasias are caused by which HPV viruses?

A

HPV 16 & 18:
• Bowenoid papulosis (benign) - vulva/penis
• Carcinoma - cervix/penis

27
Q

Which serotypes do current HPV vaccines protect against?

A

6, 11, 16, 18