CSF analysis Flashcards
What are the indications for CSF analysis?
Encephalopathies, Myelopathies, Radiculopathies
These conditions indicate the need for CSF analysis to diagnose underlying issues.
What are the contraindications/risks for performing CSF analysis?
Elevated intracranial pressure, Inadvertent penetration of parenchyma, Anesthesia requirement
These factors can increase the risk associated with CSF collection.
What is the safe volume of CSF that can be removed per body weight?
1 mL per 5kg bodyweight
This guideline helps prevent complications during CSF collection.
What can EDTA cause in CSF analysis?
Interference in interpretation, Falsely elevated protein, Falsely low cell concentrations
EDTA can affect the accuracy of CSF tests.
What are the landmarks for lumbar CSF collection in large dogs?
L4-L5
Correct identification of landmarks is crucial for safe CSF collection.
What are the landmarks for lumbar CSF collection in small dogs?
L5-L6
Proper technique is necessary to minimize risk during the procedure.
What is the appearance of normal CSF?
Clear and colorless
Any deviation from this appearance can indicate potential issues.
What does xanthochromia indicate in CSF analysis?
Yellow discoloration, prior hemorrhage, can persist for 2-4 weeks. Can also be present in icteric patients or due to markedly high protein
This condition suggests a history of bleeding in the CNS.
What is the normal WBC count in CSF?
<5 WBC/mL, predominantly mononuclear cells
Elevated WBC counts can indicate various pathologies.
What protein levels are considered normal in cisternal CSF?
<27 mg/dL
Elevated protein levels can signal underlying disease processes.
What protein levels are considered normal in lumbar CSF?
<45 mg/dL
This threshold helps differentiate between normal and pathological conditions.
What is suppurative/neutrophilic pleocytosis associated with?
Predominance of neutrophils, Bacterial infections, Some viral encephalitis, SRMA
Identifying the type of pleocytosis guides diagnosis and treatment.
What are causes of mononuclear pleocytosis?
Granulomatous meningoencephalitis, Lymphoma, Fungal infections, Viral infections
This type of pleocytosis indicates specific infectious or neoplastic processes.
Fill in the blank: Aberrant parasitic migration can cause _______ pleocytosis.
Eosinophilic
This condition can indicate the presence of parasites affecting the CNS.
True or False: Deep seated parenchymal lesions are associated with a significant increase in WBC count.
False
These lesions may show mild increase or normal WBC with elevated protein.
