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Seminar II AUBF > CSF > Flashcards

CSF Flashcards

1
Q

Site of formation

A

Choroid plexus

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2
Q

Rate of formation

A

500 ml/day or 20 ml/hour

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3
Q

Total volume

A

Adult: 90-150 mL
Neonates: 10-60 mL

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4
Q

Volume collected

A

20 mL

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5
Q

Collection techniques

A

Lumbar/spinal tap

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6
Q

Other collection techniques

A

Cisternal and suboccipital
Lateral cervical puncture
Ventricular cannula

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7
Q

Storage for Chem and Immunology samples

A

Frozen

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8
Q

Storage for Microbio samples

A

Room temperature

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9
Q

Storage for hematology samples

A

Refrigerated

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10
Q

Order of tubes for sample collection

A

Tube 1: Chem and Immunology
Tube 2: Microbiology
Tube 3: Hematology
Tube 4: Additional tests

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11
Q

Normal appearance of CSF

A

Colorless and crystal clear

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12
Q

Hazy/cloudy/turbid/milky

A

WBCs and microorganisms
Elevated protein

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13
Q

Oily

A

Radiographic contrast media

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14
Q

Clot formation

A

Traumatic tap
Damage to BBB
TB meningitis

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15
Q

Bloody

A

Traumatic tap or subarachnoid hemorrhage

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16
Q

Xanthochromic

A

Presence of RBC degradation products of other pigments
(bilirubin, carotene, elevated protein, melanin)

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17
Q

Normal viscosity

A

Non-viscous

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18
Q

[Chem exam] Total protein clinical significance

A

Increase when there is breakage in BBB, MS, hemorrhage; decrease in CSF leakage

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19
Q

[Chem exam] Total protein NV

A

15-45 mg/dL

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20
Q

Protein fractions for electrophoresis

A

[in order] pre-albumin, albumin, a-globulins, transferrin, tau protein, gamma globulins

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21
Q

Assoc dse with adenosine deaminase

A

TB meningitis

22
Q

Assoc dse with CK-BB

A

Ischemic or anoxic insult, subarachnoid hemorrhage, brain tumors

23
Q

Dse assoc with lactate dehydrogenase

A

CNS leukemia, lymphoma, metastatic carcinoma, bacterial meningitis, and subarachnoid hemorrhage

24
Q

Dse assoc with lysozyme

A

Bacterial meningitis

25
Myelin Basic Protein Clinical significance
Elevated in MS, trauma, encephalopathies, GBS, LE, tumors
26
Clinical significance of glucose
Decreased in bacterial meningitis
27
Clinical significance of lactate
Elevated in bacterial meningitis, intracranial hemorrhage
28
Clinical significance of Glutamine
Elevated in liver disorders (Reye's syndrome), coma of unknown origin, disturbance of consciousness, hepatoencephalopathy
29
NV for CSF/serum albumin index
<9
30
NV for IgG index
<0.7
31
MBP normal value (NV)
<4 ng/mL
32
NV for Glucose
65% of glucose plasma
33
Lactate
<25 mg/dL
34
Glutamine
8-18 mg/dL
35
Slightly hazy
1:10
36
Hazy
1:20
37
Slightly cloudy
1:100
38
Slightly bloody
1:200
39
Cloudy, bloody, turbid
1:10,000
40
Clinical Significance of Lymphocytes
-Tubercular, fungal, viral meningitis -HIV/AIDS -MS -GBS -lymphoma
41
Clinical Significance of monocytes
-tubercular or fungal meningitis -tumors
42
Clinical Significance of neutrophils
-Bacterial meningitis -cerebral hemorrhage
43
Clinical Significance of macrophages
Intracranial hemorrhage
44
Clinical Significance of blast forms
Leukemias and lymphomas
45
Clinical Significance of plasma cells
MS, GBS, sarcoidosis, TB and syphilitic meningitis
46
Clinical Significance of Ependymal and choroidal cells
diagnostic procedures
47
Clinical Significance of malignant cells
-Metastatic carcinomas -primary CNS carcinoma
48
Clinical Significance of eosinophils
-Parasitic infections -Fungal infections (C. immitis) -Foreign materials (meds and shunts)
49
Clinical Significance of nRBCs
Bone marrow contamination during spinal tap
50
Is there the presence of D-dimer in traumatic tap
No
51
Is there clot in hemorrhage?
No
52
What is the color supernatant in traumatic tap and hemorrhage?
TT: clear Hemorrhage: xanthochromic

Seminar II AUBF (1 decks)

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