crystal arthropathies Flashcards

1
Q

how to diagnose gout

A

needle aspiration of acutely or chronically involved joitns or tophaceous deposits

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2
Q

what can limit the value of serum uric acid for diagnosis?

A

serum urric acid levels can be nl or low during attack, as inflammatory cytokines can be uriosuric and effective initiation of hypouricemic therapy can precipitate attacks

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3
Q

treatment of acute gouty arthritis

A

NSAIDs, colchicine, or steroids

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4
Q

controlling hyperuricemia through simple means

A

control of body weight, low-purine diet, increase in liquid intake, limitation of ethanol use, decreased use of fructose-containing foods and beverages, and avoidance of diuretics

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5
Q

hypouricemic therapy

A

probenecib, allopurinol, febuxostat

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6
Q

most serious side effects of allopurinol

A

life-threatening toxic epidermal necrolysis, systemic vasculitis, bone marrow suppression, granulomatous hepatitis, renal failure

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7
Q

conditions ass. w/ calcium pyrophosphate dihydrate disease

A

aging
disease-associated (primary hyperparathyroidism, hemochromatosis, hypophosphatasia, hypomagnesemia, chronic gout, postmeniscectomy, gitelman’s syndrome)
epiphyseal dysplasias

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8
Q

what is apatite?

A

primary mineral of nl bone and teeth
- abnl accumulation of basic calcium phosphates, largely carbonate substituted apatite, can occur in areas os tissue damage (dystrophic calcification), hypercalcemic or hyperparathyroid states (metastatic calcification

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9
Q

what is another word for apatite arthropathy?

A

basic calcium phosphate disease

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10
Q

treatment for calcium apatite deposition disease

A

nsaids, colchicine, steroids

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11
Q

cause of calcium oxalate deposition disease

A

primary (metabolic disorder, rare)

secondary (end-stage renal disease)

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12
Q

what kind of supplement can increase oxalate?

A

ascorbic acid (metabolized to oxalate), which is inadequately cleared in uremia and by dialysis

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13
Q

pathophysiology of gout

A

acute and chronic arthritis caused by deposition of MSU crystals in joints and connective tissue tophi and the risk for deposition in kidney interstitium or uric acid nephrolithiasis

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