Crossover Flashcards
False about Natural penicillin:
A. Good against Streptococci and Meningococci
B. Good against Staphylococci
C. Repository formula= Penicillin G Benzathine
D. Oral preparation= Phenoxymethy penicillin
B
In addition to Penicillin G, aminopenicillin has added activity to:
A. Corynebacterium diphtheriae
B. Staphylococcus
C. Listeria monocytogenes
D. Streptococcus
C
Tue of Oxacillin except:
A. Has an activity to Staphylococcus
B. Has an activity to Klebsiella pneumoniae
C. Primarily used for parenteral treatment of serious S. pneumoniae
D. Has an activity to Streptococcus
B
True for Piperacillin-Tozabactam except:
A. Most broad spectrum available in the Philippines
B. With anaerobic activity
C. For MRSA
D. For P. aeruginosa
C
Rina is a 2 day old with untreated syphilis. Which penicillin would be given?
a. piperacilin-tazobactam
b. Co-amoxiclav
c. Meropenem
d. Penicillin G
D
compared to a 1st gen cephalosporin, a 3rd gen cephalosporin would be expected to exhibit?
A. improved activity against certain gram negative bacteria
B. lower levels of activity in the CSF
C. improved inhibition of folate synthesis by sensitive bacteria
D. AOTA
A
Which among the ff statements about cefazolin is FALSE:
A. It is effective against Staphylococcus aureus and Streptococcus
B. It has good oral bioavailability.
C. It may used for skin infections and cellulitis.
D. It has no activity against enterococcus.
B
What is the advantage of using Cefepime over Ceftazidime?
a. lesser activity against gram positive bacteria
b. higher activity against Chlamydia
c. better activity against gram negative bacteria
d. should be used in all cases in the ER
C
Cefuroxime is useful for treatment of infections caused by the following pathogens except:
a. Haemophilus influenza
b. E. coli
c. Streptococcus pneumonia
d. Legionella
C
[T/F] All clinically useful antibacterials are selectively toxic to microorganisms
F
[T/F] For an antibacterial antibiotic to be effective, it must first gain access to the target sites of action, that is or in the human host cell.
T
[T/F] The basic mechanism of action of beta-lactam antibiotics is inhibition of nucleic acid synthesis or function
F
[T/F] Compared with other pharmacological agents, antibacterial chemotherapeutic agents are reasonably safe.
F
[T/F] The word antibiotic is now often used to include antimicrobial agents, produced by microorganisms and those that are totally synthetic
F
Amoxicillin
A. Aminopenicillin B. Carboxy Penicillin C. Natural Penicillin D. Penicillinase-resistant penicillin E. Ureide Penicillin
A
Benzyl Penicillin
A. Aminopenicillin B. Carboxy Penicillin C. Natural Penicillin D. Penicillinase-resistant penicillin E. Ureide Penicillin
C
Carbenicillin
A. Aminopenicillin B. Carboxy Penicillin C. Natural Penicillin D. Penicillinase-resistant penicillin E. Ureide Penicillin
B
Cloxacillin
A. Aminopenicillin B. Carboxy Penicillin C. Natural Penicillin D. Penicillinase-resistant penicillin E. Ureide Penicillin
D
Piperacillin
A. Aminopenicillin B. Carboxy Penicillin C. Natural Penicillin D. Penicillinase-resistant penicillin E. Ureide Penicillin
E
The beta-lactam antibacterial antibiotics include the following EXCEPT:
A. Penicillin V
B. Cefuroxime
C. Meropenem
D. Cilastatin
D
This third generation cephalosporin is relatively resistant to hydrolysis by beta-lactamases and has the broadest gram-negative spectrum
A. Cefepime
B. Ceftriaxone
C. Cefuroxime
D. Cephalexin
B
Penicillin of choice for Streptococcus pyogenes is
A. Penicillin G
B. Penicillin V
C. Cloxacillin
D. Amoxicillin
A
Depot formulations of Penicillin G i.e., Benzathine Penicillin G and Procaine Penicillin G are inappropriate for meningitis
A. True
B. False
A
The activity of extended spectrum penicillins goes beyond that of the aminopenicillins as it is active against
A. Staphylococci
B. Streptococci
C. Enterococci
D. Pseudomonas
D
[T/F] Appropriate specimen collection from the infected organ system should be done day after starting antibiotic therapy
F
[T/F] Having a previous hypersensitivity reaction to penicillin G, would also predispose the patient to having a hypersensitivity reaction to another penicillin like piperacillin
F
[T/F] in treating bacterial infection in immunocompromised patient, such as those with leukemia a bacteriostactic agent is sufficient
F
The Beta-Lactam Antibacterial antibiotics are selectively toxic. Selective toxicity is
a. What the drug does to the patient
b. What the patient does to the drug
c. What the pathogen does to the patient
d. What the drug does to the pathogen
e. What the pathogen does to the drug
D
All of these drugs are beta-lactam antibiotics EXCEPT
a. Ampicillin
b. Aztreonam
c. Cephalexin
d. Gentamycin
e. Imipenem
D
The basic mechanism of action of beta-lactam antibiotics is
a. Inhibition of bacterial protein synthesis
b. Inhibition of mycolic acid synthesis
c. Inhibition of cell wall synthesis
d. Inhibition of cell membrane function
e. Interference of microbial folic acid synthesis
C
The penicillin of choice for Streptococcus pyogenes is
a. Penicillin G
b. Penicillin V
c. Cloxacillin
d. Ampicillin
e. Piperacillin
B
In order to use Beta-Lactam antibiotics effectively and safely the following principles may be followed
a. Determine the pathogen causing the infection
b. Choose the right drug
c. Administer the drug properly
d. Prevent/minimize adverse drug reaction
e. All of the above
E
The following are side effects of Penicillin, EXCEPT:
A. Rashes
B. Ototoxicity
C. Diarrhea
D. Interstitial nephritis
B
compared to a 1st gen cephalosporin, a 3rd gen cephalosporin would be expected to exhibit?
A. improved activity against certain gram negative bacteria
B. lower levels of activity in the CSF
C. improved inhibition of folate synthesis by sensitive bacteria
D. AOTA
A
Indications for Cotrimoxazole except
a. Burkholderia cepacia
b. Pneumocystis jiirovecii
c. candidiasis
d. H. influenza otitis media
D
Indication for combination therapy of aminoglycosides with beta-lactams
a. empiric therapy for serious infections, e.g. neonatal sepsis
b. infective bacterial endocarditis
c. systemic pseudomonas aeruginosa infections
d. AOTA
B
True of Tetracycline EXCEPT:
A. Has good activity against intracellular bacteria such as Legionella and Chlamydia
B. Is safe for long term use in patients less than eight years old and pregnant women
C. Long acting preparations can be given once a day or every 12 hrs
D. Side effects include photosensitivity, hepatotoxicity, and SLE
B
Erythromycin is used as an alternative drug for penicillin for many indications EXCEPT
A. Streptococcus pneumonia pneumonia
B. Mycoplasma pneumonia
C. Rheumatic fever prophylaxis
D. Syphilis
B
What is the correct indication for the usage of Chloramphenicol?
A. Malaria
B. Typhoid fever
C. Staphylococcal impetigo
D. Otitis media
B
True of Ciprofloxacin
a. It is the drug of choice for methicillin resistant Staphylococcus aureus
b. It has good activity for S. pneumonia
c. It inhibits topoisomerase II and IV
d. It is active against plasmodium
D
Aminoglycoside
A. Inhibitor of protein synthesis
B. Inhibitor of folate metabolism
C. Inhibitor of DNA gyrase
D. Inhibitor of cell wall synthesis
A
Cotrimoxazole
A. Inhibitor of protein synthesis
B. Inhibitor of folate metabolism
C. Inhibitor of DNA gyrase
D. Inhibitor of cell wall synthesis
B
Ciprofloxacin
A. Inhibitor of protein synthesis
B. Inhibitor of folate metabolism
C. Inhibitor of DNA gyrase
D. Inhibitor of cell wall synthesis
C
Tetracycline
A. Inhibitor of protein synthesis
B. Inhibitor of folate metabolism
C. Inhibitor of DNA gyrase
D. Inhibitor of cell wall synthesis
A
Vancomycin
A. Inhibitor of protein synthesis
B. Inhibitor of folate metabolism
C. Inhibitor of DNA gyrase
D. Inhibitor of cell wall synthesis
D
Clindamycin
A. Inhibitor of protein synthesis
B. Inhibitor of folate metabolism
C. Inhibitor of DNA gyrase
D. Inhibitor of cell wall synthesis
A
Meropenem
A. Inhibitor of protein synthesis
B. Inhibitor of folate metabolism
C. Inhibitor of DNA gyrase
D. Inhibitor of cell wall synthesis
D
Clindamycin
A. Teeth discoloration in children B. Gray baby syndrome C. Arthropathy in children D. Redman syndrome E. Indicated for pseudomembranous colitis
E
Tetracycline
A. Teeth discoloration in children B. Gray baby syndrome C. Arthropathy in children D. Redman syndrome E. Indicated for pseudomembranous colitis
A
Ciprofloxacin
A. Teeth discoloration in children B. Gray baby syndrome C. Arthropathy in children D. Redman syndrome E. Indicated for pseudomembranous colitis
C
Chloramphenicol
A. Teeth discoloration in children B. Gray baby syndrome C. Arthropathy in children D. Redman syndrome E. Indicated for pseudomembranous colitis
B
Vancomycin
A. Teeth discoloration in children B. Gray baby syndrome C. Arthropathy in children D. Redman syndrome E. Indicated for pseudomembranous colitis
D
Trimethoprim-sulfamethoxazole is used for the following indications EXCEPT
a. Haemophilus influenza upper respiratory tract infection
b. sepsis due to Candidemia
c. Typhoid fever
d. Pneumonia due to Pneumocystis jirovecii
B
Adverse effects of aminoglycosides include the following EXCEPT
a. Ototoxicity
b. Neuromuscular blockade
c. Nephrotoxicity
d. Redman syndrome
D