Crohn Disease Flashcards
Farmer and associates classification of Crohn disease
on the basis of location alone - ileocolic, purely colonic, small bowel, and perianal
Vienna classification
categorizes disease on the basis of location, age of onset, and disease behavior
Vienna classification - location
terminal ileum (L1), colon (L2), terminal ileum and colon (L3), and any location proximal to the terminal ileum (L4)
Vienna classification - age of onset
less than 40 years of age (A1) and 40 years of age or older (A2)
Vienna classification - disease behavior
nonstricturing and nonpenetrating (B1), stricturing (B2), and penetrating (B3)
Crohn disease of the small bowel has the
highest recurrence rate
Abscesses
particularly common with ileocolic Crohn disease
Risk of colorectal cancer is approximately
three times higher in patients with Crohn disease than in the general population
Duodenal Crohn disease can lead to
gastric outlet obstruction, and in children can be mistaken for annular pancreas
When duodenal Crohn does not respond to medical therapy,
gastrojejunostomy with vagotomy is the preferred surgical treatment
Crohn disease of the SB is not common but associated with
one of highest overall recurrence rates
Two most prevalent strictureplasty technique:
Heineke-Mikulicz and Finney
Heineke-Mikulicz strictureplasty
best suited for strictures up to 5 to 7 cm long
Finney strictureplasty
best suited for strictures up to 10 to 15 cm long
Side-to-side strictureplasty
suitable for longer areas of stricture
Crohn disease is generally more severe on
the mesenteric side of the bowel
Percent of patients diagnosed with Crohn disease that have ileocolic disease
~ 50%
The most common fistulas associated with ileocolic Crohn disease
ileosigmoid
Ileocolic Crohn disease is often associated with
intra-abdominal abscess or fistulas
Colonic involvement is present in
29 to 44% of patients with Crohn disease
Differentiation between Crohn colitis and ulcerative colitis can be difficult in the absence of
SB or anal disease
Colonic Crohn disease appears to be more frequently associated with
cutaneous manifestations (e.g., pyoderma gangrenosum)
The main indications for operative management of colonic Crohn disease are:
stricture, malignancy, side effect of medical therapy, and failure of medical therapy
Toxic megacolon
any condition associated with colitis that is severe enough to result in sloughing of the colonic mucosa, thereby permitting endodoxins to enter the circulatory system and evoke a septic response
Anal strictures pose
functional obstruction and lead to continuing problems with fistulas and suppurative disease
Anal Crohn disease without stenosis
easier to treat medically - with metronidazole and anti-TNF Ab
Mesalamine
reduces postoperative recurrence of Crohn disease
Postoperative surveillance of Crohn
no clear guidelines at present
Smoking affects
overall severity of Crohn disease - with smokers having a 34% higher recurrence rate and a higher rate of reoperation than nonsmokers