Critical Numbers Flashcards

1
Q

What is confounding variable ?

A

Alternative explanation for an observed Association

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2
Q

What is the definition of a P value?

A

A P value tells you the probability that the results were due to chance

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3
Q

What is length time bias?

A

Screening happens at regular intervals, people may be missed out due to timing of screening

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4
Q

What is leadtime bias?

A

Difference between knowing about disease and making a difference. One patient knows for two years longer that they have the disease, but both die at the same point.

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5
Q

What is selection bias?

A

People who choose to participate in screening may differ from general population e.g. may be at higher risk

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6
Q

What is a negative predictive value?

A

Proportion of people with a negative result who do not have the disease

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7
Q

What is a positive predictive value?

A

Proportion of people who have a positive screening result who have the disease

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8
Q

What is the definition of specificity?

A

The proportion of people without the disease who are correctly excluded by the screening process.

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9
Q

What is the definition of sensitivity?

A

The proportion of people with the disease who are correctly identified by the screening process.

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10
Q

What is a false positive?

A

Someone who will be screened and shown to have the disease but on further testing do not appear to have disease

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11
Q

What does secondary prevention aim to do?

A

Detect and treat a disease in its early stages

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12
Q

What is the prevention the paradox?

A

A larger number of people at small risk of disease may contribute to more cases of the disease then a small number of people who individually at a greater risk

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13
Q

What is the definition of prevalence?

A

Number of existing cases in a defined population at a defined point in time, divided by the total number of people in the population at that time

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14
Q

What is the conclusion of a small P value?

A

Your sample results are unlikely when null hypothesis is true . Conclude there is a statistically significant effect

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15
Q

When is a p value statistically significant ?

A

P value < 0.05

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16
Q

What information do confidence intervals provide ?

A

Direction of the effect.
Strength of the effect.
Variability of the effect

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17
Q

What is the difference between statistically significant and clinically significant?

A

Clinically significant difference is one that is big enough to make it worthwhile difference. Statistical significance does not necessarily mean that the effect is clinically significant.

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18
Q

What is the process for hypothesis testing?

A

Set null hypothesis and alternative hypothesis. Carry out significance test. Obtain test statistic. Compare test statistic to hypothesised critical value. Obtain P value. Less than 0.05 reject null hypothesis

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19
Q

What is a cohort study?

A

What will happen? Specify factors associated with disease risk with exposure status determined.

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20
Q

What are the strengths of a cohort study?

A

Multiple diseases/outcomes can be studied. Multiple exposures can be studied. Demonstrates casual affects.

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21
Q

What are the weaknesses of a cohort study?

A

Need to deal with potential confounding affects. Not suitable for diseases with long latent periods

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22
Q

What is a randomised controlled trial?

A

What will happen? Randomises participants then applies intervention

23
Q

What are the strengths of a randomised controlled trial?

A

Most convincing evidence of cause effect relationship. Insures treatment group similar at the start to prevent confounding.

24
Q

What are the weaknesses of randomised controlled trial?

A

Complicated by non-compliance and loss in the follow-up. Not always ethical or feasible

25
Q

What is a case control study?

A

What has happened? Retrospective direction of enquiry. Identify factors associated with the risk of disease

26
Q

What are the strengths of the case control study?

A

Relatively quick and inexpensive. Multiple exposures can be studied. Suitable for long latency diseases.

27
Q

What are the weaknesses of the case control study?

A

Only a single outcome can be studied. Exposure data must be available prior to study so limited potential to establish casual Effects

28
Q

What is a cross-sectional study?

A

What is happening? Measures prevalence, established risk factors and symptoms

29
Q

What are the strengths of a cross-sectional study?

A

Rapid feedback on current events. Quick and cheap

30
Q

What are the weaknesses of cross sectional study?

A

Confounding problems, and difficult to establish disease aetiology.
Selection bias

31
Q

What does standard error measure?

A

Measures variability of a sample estimate of the population parameter

32
Q

What is standard deviation?

A

Describes variability of observations in sample. The higher the standard deviation the more difficult to get representative data.

33
Q

How do you calculate a confidence interval?

A

To standard errors above and below sample mean

34
Q

What do the widths of the confidence interval depend on?

A

Sample size. Variability of data. Level of confidence.

35
Q

What are the two methods to compare risk?

A

Absolute risk.

Relative risk difference

36
Q

What is the definition of number needed to treat?

A

Number of people you need to treat in order to prevent one outcome

37
Q

What is the definition of number needed to harm?

A

Number of people you need to treat in order to cause one additional outcome.

38
Q

In critical appraisal what does RAAMbo stand for?

A

Representative
Allocated or adjusted
Accounted for
Measurement blind or objective

39
Q

What do you call the analysis of statistics and a systematic review?

A

Meta analysis

40
Q

What does P.I.C.O stand for?

A

Population/patient
Intervention
Comparison
Outcome

41
Q

Name five of the CASP checklist for randomised controlled trial?

A

Were all persons blind to study group?
What is their consistency between groups?
Were there enough participants?
Did the study ask a clearly focused question?
Was it an RCT?

42
Q

What is an ecological study?

A

Observational study, uses routine data from population looks at prevalence trends and correlation

43
Q

What is Association?

A

Existence of relationship between variables

44
Q

What is causation?

A

Existence of casual relationships between variables, cause must proceed affect

45
Q

What three things should you consider when doing a systematic review?

A

Validity
Reliability
Applicability

46
Q

What is a systematic review?

A

A review of clearly formatted questions that uses systematic methods to critically appraise evidence and to collect and analyse data from studies included in the review

47
Q

What is the Gini coefficient?

A

Statistical representation of Nations income distributed among residents.

48
Q

What are the two types of numerical data?

A

Discrete data and continuous data

49
Q

What is numerical data?

A

Data that has a measurement such as a persons height or weight

50
Q

What is discrete data?

A

Discrete data represents items that can be counted,

51
Q

What is continuous data?

A

Continuous data represents measurements, the possible values cannot be counted and can only be described using intervals on the real number line.

52
Q

What is categorical data?

A

Categorical data represent characteristics such as persons gender, marital status

53
Q

What is ordinal data?

A

Ordinal Data mixes numerical and categorical data. The data falls into categories but the numbers placed in the categories have meaning. For examples, rating a restaurant on a scale from 0 to 4