Critical Numbers Flashcards
What is confounding variable ?
Alternative explanation for an observed Association
What is the definition of a P value?
A P value tells you the probability that the results were due to chance
What is length time bias?
Screening happens at regular intervals, people may be missed out due to timing of screening
What is leadtime bias?
Difference between knowing about disease and making a difference. One patient knows for two years longer that they have the disease, but both die at the same point.
What is selection bias?
People who choose to participate in screening may differ from general population e.g. may be at higher risk
What is a negative predictive value?
Proportion of people with a negative result who do not have the disease
What is a positive predictive value?
Proportion of people who have a positive screening result who have the disease
What is the definition of specificity?
The proportion of people without the disease who are correctly excluded by the screening process.
What is the definition of sensitivity?
The proportion of people with the disease who are correctly identified by the screening process.
What is a false positive?
Someone who will be screened and shown to have the disease but on further testing do not appear to have disease
What does secondary prevention aim to do?
Detect and treat a disease in its early stages
What is the prevention the paradox?
A larger number of people at small risk of disease may contribute to more cases of the disease then a small number of people who individually at a greater risk
What is the definition of prevalence?
Number of existing cases in a defined population at a defined point in time, divided by the total number of people in the population at that time
What is the conclusion of a small P value?
Your sample results are unlikely when null hypothesis is true . Conclude there is a statistically significant effect
When is a p value statistically significant ?
P value < 0.05
What information do confidence intervals provide ?
Direction of the effect.
Strength of the effect.
Variability of the effect
What is the difference between statistically significant and clinically significant?
Clinically significant difference is one that is big enough to make it worthwhile difference. Statistical significance does not necessarily mean that the effect is clinically significant.
What is the process for hypothesis testing?
Set null hypothesis and alternative hypothesis. Carry out significance test. Obtain test statistic. Compare test statistic to hypothesised critical value. Obtain P value. Less than 0.05 reject null hypothesis
What is a cohort study?
What will happen? Specify factors associated with disease risk with exposure status determined.
What are the strengths of a cohort study?
Multiple diseases/outcomes can be studied. Multiple exposures can be studied. Demonstrates casual affects.
What are the weaknesses of a cohort study?
Need to deal with potential confounding affects. Not suitable for diseases with long latent periods