Critical Care Flashcards
Describe what the flow phase is and the nutritional/metabolic consequences of this are
A phase of metabolic instability and catabolism.
Characterised by:
1. hypermetabolism
2. hypercatabolism
3. lean body mass wasting
4. hyperglycaemia
5. fluid accumulation
How is protein energy malnutrition affected by duration of critical illness?
More likely to occur in prolonged periods of critical illness
Describe the ebb phase of metabolic responses o stress
the early phase of haemodynamic instability = management is most intense during this phase.
Impact of acute phase/ebb phase on the body’s nutrition status/metabolic consequences
- body = in rapid catabolism i.e. super metabolic, using a lot of nutrient stores from within the body
- Insulin resistance = the degree of hyperglycaemia is parallel to the severity of injury/illness
- Amino acids and other key substrates are mobilised from various body storage sites (esp. muscle)
Why is it important to provide rapidly available energy when patient is in ebb/acute phase?
so that enough energy is provided for the immune system and other key organs as patient fights to survive.
What is a negative consequence of cachexia in ebb phase?
A lot of muscle wasting = harder to fight infections and injury.
How long does ebb phase last and what is the effect on metabolic activity, oxygen consumption and temperature.
Where does body get energy from?
First 24-48 hours
- reduced metabolic activity
- reduced oxygen consumption
- reduced body temperature
Energy reserves (glycogen from liver into glucose; and fatty acids from adipose tissue) = mobilised but there is impaired ability to utilise them.
How long does flow phase last and what is the effect on metabolic activity, oxygen consumption and temperature.
Can last a long time.
- hyper metabolism
- catabolism
- increased oxygen consumption
What are mechanisms in the body mediated by? (3)
- cytokines
- hormones
- changes in nutrient metabolism
Describe the mechanism by which counter regulatory hormones induce catabolism and glucose intolerance
- increased levels of hormones, catecholamines, glucagon and cortisol = increased protein metabolism and therefore catabolism
- can = hyperglycaemia and insulin resistance
- glucagon stimulates gluconeogenesis; cortisol increases net protein catabolism and catecholamines => glucose intolerance
How do cytokines stimulate lean tissue breakdown?
- increased circulating levels of pro- and anti-inflammatory cytokines
IL-1 ; IL-6 and TNF-alpha = major pro-inflammatory mediators
in conjunction with hormones that have an effect on hepatic and peripheral tissue to increase lean muscle has breakdown and loss.
What is the time frame for initiating nutrition therapy in ICU patients?
All ICU patients >48 hours
What is the aim of nutrition therapy in ICU patients? (4)
- help reduce disease severity
- diminish complications
- improve patient outcome
- attenuate rate of lean tissue loss
What is a symptom caused by non-invasive respiratory support that can limit oral intake?
- dry mouth
- unable to eat or drink enough because of having to remove ventilator support
What is the maximum rate of glucose provision?
5mg/kg/min