Crescentic GN

Question 1

Drugs associated with vasculitis

Answer 1

hydralazine (double positive ANCA)
pembrolizumab and other checkpoint inhibitors (vasculitis in many organ systems, but more commonly AIN)
opana (drug of abuse, opioid)

Question 2

Drugs that can cause TMA

Answer 2

(glomerular limited TMA) - avastin (Bevacizumab) or other anti-VEGF inhibitors - tends to be dose dependent in risk but even intraocular can do it
-Quinine — Until 2010, quinine was the most common cause of immune-mediated DITMA
-Antimicrobials — The antibiotic with the best evidence is trimethoprim-sulfamethoxazole. A number of other antibiotics have evidence for causing immune-mediated DITMA in single case reports, including (Sulfisoxazole, ciprofloxacin, penicillin, metronidazole, mefloquine, famciclovir)
-Rifampin
-Chemotherapies (Gemcitabine, Mitomycin, Pentostatin, Vincristine)
-Proteosome inhibitors ((bortezomib, carfilzomib, and ixazomib))
-mTOR inhibitors (like sirolimus)
-Drugs of abuse (Intravenous use of the extended-release opioid oxymorphone, Ecstasy (MDMA, also known as Molly), Cocaine)