Creogs R2 Flashcards
Chance of occult cancer in VIN 3
3%
Margins on excisional bx of VIN
0.5-1.0 cm
Laser ablation for VIN 3, extend through which layer?
Dermis
What type of virus is HPV?
small double-stranded DNA
Co factors with HPV that increase risk of cervical dz
smoking, OCPs, HIV, Pregnancy
Seizure med to use in myasthenia gravis pts
kepra (levetriraceptam)
Most common sex chromosomal abnormality
47 XXY- Klinefelder’s, 1/500 chance
Most helpful test to dx Grave’s dz
TSH receptor ab
How long should you wait to conceive after radioactive iodine ablation
6 months
How long should you wait to conceive after bariatric sx?
12 months
Most common cause of hirsutism in pregnancy
ovarian luteoma
holoprosencephaly is associated with which chromosomal abnl?
trisomy 13
Most common congenital anomaly is what system?
CV (VSD) #2 is CNS
Pap with NILM, + HPV, next step?
HPV genotyping
co-testing starts at what age?
30yo
Colpo with CIN 3, without treatment chance of developing invasive ca?
5-10% in 5-10 yrs
Risk of high-grade cervical dysplasia w/in 5 years of negative contesting?
0.1%
inconclusive cffDNA, next step?
refer to MFM, offer ultrasound, diagnostic testing
How much fetal DNA mus be present in cffDNA?
4% (high BMI dilutes)
Treatment of IB3 cervical ca?
rad hyst with pelvic LAD
patient takes pyrisostigmine, whats contraindicated in labor?
Mag
Most appropriate age to start DEXA scan
65yo
ABX choice for syphillis during pregnancy in pt with PCN anaphylaxis
PCN after desensitization
Malignancy most likely to metastasize to placenta
Melanoma
Most common malignancy in pregnant woman
breast ca
2nd most common type of vulvar ca
melanoma
Most common early postop complication s/p rad vulvectomy with LAD
lymphocyst
Best way to dx premenstrual dysphoric d/o?
daily symptom diary
Most common karyotype in complete molar pregnancy
46XX (completely dad)
Most common CF mutation
delta F508
most common cause of ambiguous genitalia
CAH
BRCA1 and 2 and what types of genes?
tumor suppressor genes
Most common HPV type in high grade cervical dz
HPV 16
National Data Base is used to…
record medical malpractice awards paid by docs to plaintiffs
Most common site of mets of gestational trophoblastic dz
Lungs (stage 3)
Most effective BC
implant
Persistent OP is common in which pelvis type?
Anthropoid
Cohort studies are
prospective
Case control studies are
retrospective
Most common sexual disorder in females
hypoactive sexual disorder
Most common cause of hirsutism
PCOS
Sacral agenesis occurs with what?
uncontrolled maternal DM
Best nonhormonal treatment for hot flashes
Paxil (paroxetine)
How is CAH inheritied
AR
The highest concentration of fibrinogen is in
Cryo
Treatment for PMDD
SSRI
Most common sign of uterine rupture
NRFHT
First line pressor for hypovolemic shock
norepi
Echo shows what in PPCM?
LVEF <45%
US finding most c/w accreta
turbulent placantal lacunae
Most common cause of PMB
atrophy
Which imaging modality gives the most radiation in pregnancy?
CT or CT-PE
For pt with h/o T5 spinal cord injury, what do you do to prevent autonomic dysreflexia?
early regional anesthesia
Physiology of blood gases in pregnancy
resp alkalosis with compensatory met acidosis
In addition to glycemic control, what is acute therapy for DKA?
aggressive fluid resuscitation
Strongest risk factor for Pre-E
APAS
Strongest risk for PP infxn
c-section
Names of incisions in normal LTCS
Pfannenstiel, Kerr (uterine)
Mechanism of action of TXA
prevents degradation of fibrin through inhibition of plasminogen
Pregnant ot with pheo, HTNive- first med you give?
phenoxybenzamine (alpha blocker)
Treatment for ovarian hyperthecosis
BO
Most common cause of woman with Kell ab
h/o blood trx
What to do if pregnant woman has Kell ab
test FOC (if neg ok)
Most common symptoms of vaginal cuff dehiscence
abundant vaginal discharge
Average growth of dermoid per year
1.8 mm
Biggest risk factor for invasive cervical ca
never had a pap before
BI-RADS 0 on mammo means
incomplete exam
Most common causes of 1T losses
trisomy 16, turners, polyploid
what causes hypoTN after CLE placement
local anesthetic effect on sympathetic fibers
Most common side effect of tamoxifen
hot flashes
Leading cause of trauma in pregnancy
DV
Risk of seizure in severe pre-e without mag
2-3%
Typical eclamptic seizure lasts
less than 4 min
Purpose of mag in eclampsia
prevent next seizure
t1/2 of acetaminophen
3.5 hours
PPCM occurs
last mo preg, first 5mo PP
Most common cause of cancer death in women in US
lung cancer
when do you star a bisphosphonate
hip frx risk >3% or mjr frx risk > 10%
Characteristics of yolk sac tumor
Schiller-duval tumors, make AFP
Characteristics of granulosa cell tumor
solid mass, vaginal bleeding, inhibin, call-exner bodies
MOA of oxybutynin
anti-muscarinic
Injury to which nerve during GYN surgery causes motor dysfxn
obturator nerve
Recommendation for delivery in pt with accreta
CS at 34 w
Incision when rectus is transected at their origin at the pubic symphysis
Cherney
Most common cause of C-hyst
accreta
Accreta is absence of which cell layer
decidua basalis
Average ES thickness in women with endometrial ca
35mm
Recurrence risk of gDM
50%
T sign is in
di-di twins
lamba sign is in
di-di twins
Advanced paternal age increases risk of
autosomal dominant dz
Most common OB condition that results in DIC
abruption
Most common side effect of TXA
headache
WHat accelerate menopausal occurence
smoking
Actinomyces on IUD, next step
manage expectantly
Most common cause of primary ovarian failure
idiopathic
Which incision puts inferior epigastric vessels at risk
Maylard
Mode of inheritance of neural tube defects
multifactorial
What ovarian volume is diagnostic of PCOS
15mm
Sterilization at highest risk of failure
spring clip applicator
postterm pregnancy is commonly associated with which fetal condition/.
anencephaly
MOA of heparin
combines with ATIII
Typical sequence of puberty is
adrenarche (growth spurt), thelarche (breast bud), pubarche (pubic hari), peak growth spurt, menarche, ovulation
What aspect of GnRH causes puberty
amplitude, not frequency
MOA of warfarin
inhibits vitamin K dependent factors (2,7,9,10,C and S)
MOA of rvaroxaban
inhibits Xa
MOA of letrazole
aromatase inhib, inhibits androgens from becoming estrogen
MOA of cyclophophamide
alkylating agent, use with mesna to prevent hemorrhagic cystitis
MOA of 5-fluorouracil
nucleoside inhib
MOA of MTX
inhibits dihydrofolate reductase
MOA of bleomycin
causes DNA breaks (causes pulmonary fibrosis which is worsened by O2)
MOA of doxorubicin
prevents double stranded DNA repair, causes CM and palmar redness
MOA of Taxol
binds to microtubules
MOA of cisplatin
cross links DNA to prevent replications; causes nephrotoxicity
MOA of Sumatriptan
serotonin receptor agonist
MOA of Bisphosphonates
inhibit osteclasts
MOA of Oloparib (PARP)
inhibits poly (ADP-ribose) polymerase, for BRCA+ ca
MOA of metformin
decreases hepative gluconeogenesis
MOA of hydral
smooth muscle relaxant
MOA of mirabegron
beta 3 agonist, relaxes bladder (not to be used with HTN)
MOA of methergine
smooth muscled constrictor via serotonin receptors
most common adverse effect of implant
AUB
Most common extrauterine spread of endometrial ca
lymph nodes
Another term of EIN
complex endometrial hyplerplasia with atypia
Chance of concurrent cancer in pt with complex endometrial hyplerplasia with atypia
40%
HPV 16 is associated with what type of cancer?
squamous cell carcinoma
HPV 18 is associated with what type of cancer?
adenocarcinoma
When should surgical management of dermoid be considered?
symptomatic or >5 cm or malignant features//always cystectomy, not oophorectomy
Incidence of recurrence of dermoid?
3-4%
Dermoid can develop into which type of cancer
squamous cell carcinoma
h/o PTD, what GA are CXL indicated in asymptomatic women
16-24w
What antenatal testing is indicated in gDMA1
none
Definition of poly
MVP > 8cm; AFI >25
Definition of oligo
MVP < 2 cm; only use MVP in 3T; AFI <8
When does cleavage occur in di-di twins?
days 1-3
When does cleavage occur in mo-di twins?
4-8 days
When does cleavage occur in mo-mo twins?
8-13 days
When does cleavage occur in conjoined twins?
13-15 days, most commonly thoracic-abdominal
Most common karyotypes in duodenal atresia
1) normal (2/3) 2) trisomy 21 (1/3)