CPTP 3.12 - Choosing the Right Antibiotic

Question 1

Name the three major bacteria causing meningitis in infants?

Answer 1

Group.B streptococcus
Listeria monocytogenes
E.coli

Question 2

Name the three major bacteria causing meningitis in childhood?

Answer 2

Haemophilus influenza
Neisseria meningitidis
Strep pnuemoniae

Question 3

Name the major bacteria causing meningitis is adults?

Answer 3

Neisseria meningitidis

Question 4

Name the three major bacteria causing meningitis in the elderly?

Answer 4

Neisseria meningitidis
Listeria monocytogenes
Strep pneumoniae

Question 5

What is the antibiotic of choice in a presentation of bacterial meningitis?

Answer 5

Cefotaxime (cephalosporin) = inhibits penicillin binding protein and hence prevents bacterial cell wall formation

Question 6

Name two classes of antibiotics effective against gram positive bacteria?

Answer 6

Penicillins - Amoxycillin//benzylpenicillin//fluclocaxacillin
Vancomycin

Question 7

Name two classes of antibiotics effective against gram negative bacteria?

Answer 7

Aminoglycoside - Gentamycin

Quinilone - ciprofloxacin

Question 8

What are the limitations of rifampicin?

Answer 8

Young females on the oral contraceptive pill will be at danger - Rifampicin induced the cytochrome P450 and therefore leads to the metabolism of oral contraceptives

Question 9

Which particular meningitis inducing bacteria is NOT sensitive to cefotaxine?

Answer 9

Listeria monocytogenes

Question 10

Late-onset syndrome of meningitis of a newborn is usually caused by what?

Answer 10

Bacteria transmitted from vaginal flora during parturition

Question 11

Early-onset syndrome of meningitis of a newborn is usually caused by what?

Answer 11

Passed in utero via placenta

Question 12

Which particular meningitis inducing bacteria in neonates are sensitive to cefotaxine?

Answer 12

Group.B streptococcus

E.coli