CPT GI PHARM

Question 1

alginate and antacids ( Gaviscon):

1. compounds in the prep ( 3)
2. SE
3. CI
4. DDI
5. indication

Answer 1

1. Alginic acid- sodium alginate
   antacids- MG carbonate and Al hydroxide
2. Mg cause diorrhea and Al cause constipation
3. high sucrose avoid in Diabetes, Na and K prep avoid in renal faliure
4. reduce absorption of other drugs
   increase urine alkalinity so inc excretion of aspirin
5. GORD

Question 2

1. name 2 PPI
2. MOA
3. SE
4. CI
5. DDI
   6.indication
   usually prescribed with

Answer 2

1. Lansoprazole and omeprazole
2. inhibit H/K exchanger , final step in making HCL
3. GI disturbance, headache, drowsiness, confusion
4. mask Sx of GO cancer
   fracture risk in oseoperosis
5. omeprazole is a CYP inhibitor so it reduces effectiveness of clarithromycin and inc effect of waarfin and phenytoin
6. prescribes with NSAIDS and steroid ( inc risk of ulcer)

Question 3

1. H2 receptor antagonists one example
2. why less effective
3. SE
4. CI
5. DDI
6. indication
   why on recall

Answer 3

1. Ranitidine
2. only inhibits one pathways of acid production
3. low SE, diorrhea and headache
4. renal faliure, mask Sx of GO cancer
5. reduced exposure to some antivirals and protien kinase inhibitors
6. PUD
   carcinogenic contaminent

Question 4

Aminosalicylates give one eg 
1. SE
2.CI 
3. DDI 
4. indication
MOA

Answer 4

mesalazine 
1. nausea, dyspepsia, leukopenia 
2. similar hypersensitivity as aspirin 
3. enteric-coated tablets break down quicker in the presence of PPI 
4. first line UC 
topical action at  colon