CPS Statements 2019 Flashcards
5 risk factors for IDA in <2 years?
HAEM Problem: High milk intake Anemic mother Early cord clamping Male Premature Also: BW<2500g, Low socioeconomic status, infants born to moms with obesity, exclusive BF x 6 months, prolonged bottle use, chronic infection, lead exposure, low intake of Fe-rich foods
What is NOT associated with IDA?
a) Indigenous status
b) Lower motor function
c) chronic disease
d) macrosomia
Macrosomia
At what point do infants who are breastfed become Fe def?
6 months (so, at this time: introduce Fe-rich foods)
Cow’s milk daily limit for 9-12 mos?
750 ml/day
once 12 mos, lowers to 500 ml/day
Exclusively breastfed infants get how much Fe per day?
0.05-0.07 mg/kg/day
Formula fed would be 1-2 mg/kg/day
PREM formula fed would be 2-3 mg/kg/day
a) Write Rx for toddler with IDA secondary to poor intake (assume weight of 10 kg) b) When do you follow up? c) What two tests at follow up?
a) Elemental Iron 6 mg/kg/day= 60 mg/kg/day= 20 mg PO TID, to take with orange juice x 30 days; Repeat x 2
b) 3 months
c) CBC, ferritin
2 differences with AAP and ESPHAGAN guidelines?
AAP: If mostly BF, automatic Fe supplementation at age 4-6 mos
ESPHAGAN: No cow’s milk until 12 mos (same limit though of 500 cc at this time)
How much iron should formula contain?
6.5-13 mg/L Fe
Should infants 4-6 mos automatically receive Fe supp?
Not according to CPS
Infants with BW 2-2.5 kg: Supplement how much iron? for how long?
1-2 mg/kg/day x 6 months
Infants with BW <2 kg: Supplement how much iron? For how long?
2-3 mg/kg/day x 1 year
SAQ: Give the definition of
hypoglycemia in the first
week of life (2 points)
<2.6 within first 72 hours;
<3.3 after first 72 hours
Give 5 signs/sx of
hypoglycemia in newborn
- Tremors /jitteriness
- Cyanotic episodes
- Convulsions
- Apneic spells
- high-pitched/weak cry
- Lethargy
- Poor feeding
SAQ: Give 5 risk factors for
hypoglycemia
Mnemonic:Sugar SLIP SGA Steroids (antenatal) LGA IUGR Prematurity
Also:
Asphyxia (perinatal)
Diabetic Mother
Labetalol (Maternal)
MCQ: Babies with hyperinsulinism may need target glucose of?
- 6
- 8
- 2
- 3
3.3
Who does not need to be tested for hypoglycemia
Term, not-at risk or symptomatic infants
SAQ: Well at-risk baby has glucose <2.6 at 2 hours of life. Do what? (3 points)
Give 40% dextrose gel and breastfeed OR feed 5 ml/kg and breastfeed
Check glucose 30 min post-feed
SAQ: At-risk baby has glucose at least 2.6 at first check at 2 hours of life. Do what? (2)
Feed ad lib
Check glucose again before next feed
At second check (if tolerated feeds), do what if glucose <1.8? (3)
Initiate D10W infusion at hourly requirements
If sx, give D10W bolus 2 ml/kg over 15 min
Check BG after 30 minutes
In addition to scenario with baby having glucose <1.8 at second check post birth, what other scenarios would warrant plan described below?
Initiate D10W infusion at hourly requirements
If sx, give D10W bolus 2 ml/kg over 15 min
Check BG after 30 minutes
Unwell infant/Symptomatic infant
Infant who should not be fed
After starting IV glucose, what’s the target range for infants <72 hours of age?
2.6-5.0
After starting IV glucose, what’s the target range for infants at least 72 hours?
3.3-5.0
If after 30 minutes of infusion, BG is still too low, do what?
Increase D10W infusion by 1 ml/kg/h every 30 min; repeat glucose every 30 min until within target range
2 things you should calculate during glucose infusion?
- Lowest GIR at which BG is within target range
- D%W concentration at which BG is within target range
How do you calculate GIR?
[% dextrose concentration x infusion rate (cc/kg/h)] divided by 6
Check lytes how often during dextrose infusion?
q8-12h
GIR at which you should consider central access and level 3 care?
> 8-10 mg/kg/min
GIR at which you should consider medication?
> 10-12 mg/kg/min
After 72 h, GIR in which further investigation required?
> 10-12
For infants who are tolerating feeds, at second glucose check, do what if glucose 1.8-2.5? (3 points)
For infants who are tolerating feeds, at second glucose check, do what if glucose 1.8-2.5? (3 points)
- Give 40% dextrose gel 0.5 ml/kg AND feed 5 ml/kg and breastfeed
- OR feed 8 ml/kg and breastfeed
- check glucose 30 min post-feed
For infant tolerating feeds, if at second glucose check glucose is at least 2.6, do what?
Once 2 consecutive samples at least 2.6, continue monitoring pre-feed or every 3-6 hours
If after 2 feeds, glucose less than 2.6, do what?
Go into infusion pathway (treat as if symptomatic)
For babies undergoing infusions, do what for readings at least 2.6? (3)
- monitor q3 hours
- when glucose at least 2.6, introduce enteral feeds as tolerated and wean IV stepwise (TEXT says wean after BG stable x 12 hours)
- Continue pre-feed glucose monitoring until on full enteral feeds and 2 consecutive samples within normal range
At what time should first glucose screening happen?
2 hours of life (or immediately if baby unwell)
If BG at least 2.6 for 12 hours, for whom can you discontinue screen? (2)
LGA, IDM
If BG at least 2.6 for 24 hours, for whom can you discontinue screen? (2)
SGA, Prem
Indication for critical sample?
BG<2.8 at 72 hours or more of life
Before discharge, neonate should be able to maintain BG >3.3 for how long?
5-6 hours
Prior to 72 hours of life, BG cut-off for further investigation?
2.6 (2.8 after 72 hours)
If feeding does not work, what’s your IV dextrose order?
IV D10W at TFI 80 ml/kg/day
GIR= 5.5 mg/kg/min
How do you prescribe dextrose bolus (controversial as per text)?
D10W at 2 ml/kg IV
3 meds for hypoglycemia
HGOD Hydocortisone Glucagon Octreotide Diazoxide
Max dextrose concentration for PIV?
20%
Max TFI during transitional period?
100 ml/kg/day
Rx for dextrose gel
40% dextrose gel 0.5 ml/kg intrabuccal; give concurrently with enteral feeds
“40% dextrose gel 0.5 ml/kg intrabuccal” is equivalent to what?
IV bolus of D10 2 cc/kg
2 ways to prescribe glucagon?
0.1-0.3 mg/kg IV bolus
10-30 ug/kg/hr IV infusion
2 pros of dextrose gel?
Decrease NICU admission rate
Decrease treatment failure
Decrease supplemental formula
2 cons of dextrose gel
No improvement in developmental outcome
Similar neurosensory impairment long-term
10 items on critical sample?
"AB2C2 FG2 IL" Cortisol Beta-hydroxybutrate FFA Glucose (plasma) Insulin Bicarbonate Acyl-carnitine profile Carnitine Lactate GH
In healthy newborns, BG can be as low as ___ transiently
1.8
Enteral supplementation appropriate for whom?
No sx
BG 1.8-2.5 (recheck 30 min later)
All birthing centres should use BG measurement methods that are reliable within what range? 0.5-2.5 1-3 1.5-3.5 2-5
1-3
3 categories of pain control?
Physical, Psychiatric, Pharmaceutical
Give 3 examples of physical pain control?
Breastfeeding, sucrose, non-nutritive sucking, Insert IV at same time as BW, grouping labs, avoiding daily labs, less painful approach
Give 3 egs of psychiatric pain control?
Preparation (if >4 yrs)
Distraction
Deep Breathing
Hypnosis
Give 3 egs of pharm pain control?
EMLA= lidocraine prilocaine 5%
Maxilene= liposomal lidocaine 4%
Ametop= amethocaine 4%/tetracaine
Pain Ease= Vapocoolant spray
Arrange the following in order of onset (Fastest-> Slowest):
Maxilene, EMLA, Ametop, Pain Ease
Pain Ease= immediate
Maxilene, Ametop= 30 min
EMLA= 60 min
Arrange the following in order of max application time (longest to shortest):
Ametop, EMLA, Maxilene, Pain Ease
EMLA 4 hours
Maxilene 2h
Ametop 1 hour
Pain Ease 10 sec
Arrange the following in order of duration of efficacy after removal (longest to shortest)
Ametop 4 hours
Maxilene
EMLA 1-2 h
Pain Ease 45-60 s
Advantage of EMLA?
No cross-sensitivity with Ametop
Advantage of maxilene?
rapid action
occlusion not required
No cross-sensitivity with Ametop
Advantages of ametop?
Rapid action
Superior to EMLA
No cross-sensitivity with lidocaine
Avantage of pain ease?
immediate
Side effects of EMLA? (3)
vasoconstriction
methemoglobinemia (increased if <1 yo)
hypersensitivity (rare)
Side effect of maxilene?
methemoglobinemia (rare)
Side effect of ametop?
Hypersensitivity
Side effects of pain ease? (2)
Burning sensation
Frostbite
Which analgesia topicals cannot be applied to open wound/mucosa/eyes?
emla, maxilene, ametop
Which topical analgesic would be contraindicated in pt with PABA= paraaminobenzoic acid or sulfonamide allergy?
ametop
which topical analgesic is contraindicated for patient with heart block?
maxilene, emla
which topical analgesic is contraindicated for patient with severe hepatic d/o?
maxilene, emla
which topical analgesic is CONTRAINDICATED for methemoglobinemia?
emla
which topical analgesic is CONTRAINDICATED for g6pd?
emla
which topical analgesic is contraindicated for <3 yrs?
pain ease
Give 2 procedures for which positioning and BF/sucrose is not helpful?
Laceration Repair
X-ray for fracture, dislocation
Which analgesic can go in eyes but not mucosa/open wound?
pain ease
Positioning to control pain is NOT helpful for what?
urine collection
pharmaceutical analgesic for lac repair?
LET +/- infiltrative anesthetic with bicarb, small needle
Mod-severe pain control for fracture?
IN fentanyl
Less painful way to get urine: catheter or SPA?
catheterization
Mild sedation agent that can be easily combined with EMLA?
nitrous oxide (in cooperative children)
2 symptom domains of ASD?
1) social communication impairments, and 2) restricted, repetitive patterns of behaviours and interests.
ASD can be reliably diagnosed by age ___
2 yrs
mean age of dx for ASD?
4-5 yrs
2 strong RFs for ASD
male sex; positive fam hx
Recurrence risk for siblings of children with ASD?
7-19%
rate of ASD in general population?
1.5%= 1/66
The Dx criteria for ASD has 7 features according to the CPS statement, including the 2 symptomatic domains of
1) social communication impairments, and 2) restricted, repetitive patterns of behaviours and interests. In addition to these components, give 5 other features of ASD dx?
- Signs or symptoms must be present during early development but they may not be fully evident until later
- Symptoms interfere with everyday functioning
- Symptoms are not better explained by intellectual disability or global developmental delay
- ASD may occur with or without medical, genetic, neurodevelopmental, mental or behavioural disorders, or an intellectual or language impairment
- Level of severity for each of the two domains may be used to refine diagnosis: Level 1: Requiring support; Level 2: Requiring substantial support; Level 3: Requiring very substantial support. These levels may be difficult to determine at the initial time of diagnosis with very young children.
Give 5 risk factors for ASD
SOCIAL Miss:
- Specific genetic syndrome
- Older parents (at least 35)
- Close spacing of pregnancies (<12 mos)
- In utero exposure to traffic-related air pollution
- ASD in family
- Low BW
- Male
Others: extreme prem, in utero exposure to pesticide, valproate; maternal obesity, diabetes, htn
Give 3 warning signs for ASD in patient age 6-12 mos
- Reduced smiling directed at others
- Limited or no eye contact
- Limited recipriocal sharing of sounds, facial expression
- Diminished babbing, gestures
- Limited response to name when called
Give 2 warning signs for ASD in age 9-12 mos
- emerging repetitive behaviours (eg: spinning or lining up objects)
- unusual play (eg intense visual or tactile exploration of toys)
give 3 warning signs of ASD in age 12-18 mos
No single words
Absence of compensatory gestures (such as pointing)
Lack of pretend play
Limited joint attention (initiating, responding, sharing of interests)
Give 1 warning sign of ASD in age 15-24 mos
Diminished, atypical, or no spontaneous or meaningful two-word phrases
Give 2 warning signs for ASD irrespective of patient age
Parental and other caregiver concerns about the possibility of ASD
Developmental regression (loss of skills): reduced frequency or loss of social behaviours (e.g., directing eye gaze to others) and communication (words and gestures) relative to earlier age
Give 5 ASD screening tools
PLACE, SIMA, SR Parental qs: ASQ-3 CDI ECSA PEDS Looksee Checklist
Parent/teacher qs M-CHAT R/F ITC SRS-2 Preschool Autism Spectrum Rating Scales
Interactive:
STAT
RITA-T
Which ASD screening tool takes the least amount of time?
ECSA: 1-5 min
Which ASD screening tools can be used as young as 1 month of age?
ASQ-3
Nippising
Which ASD questionnaire can be used up to age 15 y?
Autism Spectrum Rating Scales
Does CPS recommend routine ASD screening?
Not at this time (not unless identified as being at increased risk for ASD)
3 interventions while awaiting referral for ASD dx
SLP
OT
Preschool program
Also audiology, vision testing
5 things to include in ASD referral
- Parental or health care professional reports of signs or symptoms of ASD, developmental delays or concerns, missed developmental milestones, abnormal behaviours, plus any general development or ASD screening results
- Clinical observations of signs or symptoms of ASD
- Antenatal and perinatal histories
- Developmental milestones achieved
- Any specific risk factors for ASD
- Relevant medical history and investigations
- Information from previous assessments
5 things to do to prepare for first time office visit with child suspected of ASD
-Consider scheduling a telephone call with a parent in advance of the first visit, to discuss the child’s:
Medical and developmental history, with related family factors
Strengths and challenges
Sensory sensitivities that might influence behaviour within the office environment; and
Strategies to optimize compliance during the clinical visit.
-Consider inviting both patient and parent for a ‘practice visit’ to familiarize the child with the care setting.
-Consider scheduling the child for the first (or last) appointment of the day, when there are fewer people in the waiting room, to minimize wait time.
-Schedule a longer appointment than for a typically developing child.
-Advise parent(s) to bring a couple of favourite toys or foods to offer as a distraction or reward, if needed.
-Consider re-arranging the examination room to accommodate sensory sensitivities (i.e., quiet, with dim lights).
3 approaches to diagnosing ASD?
1) Sole pediatric care practitioner using DSM 5
2) Shared care model: clinician + another HCP
3) Team-based approach with multi-D team (sometimes need this for accessing specialized services)
What should the first PCP consider for ASD dx?
- Dev, med, fam, social hx
- Info from school, child care, community
- Audiology, vision assessment
- Direct clinical observation
- +/-ASD dx tool
- DSM 5 dx criteria
If peds PCP can confirm ASD dx, next steps? (4)
- Discuss results (with written report)
- refer for individualized interventions adn community based services
- Conduct or refer for other assessments as needed
- Provide fam support services
If peds PCP can’t confirm ASD (dx uncertain), do what next? (4)
- Obtain a second opinion from other ASD specialists
- Acquire additional info from diff community settings
- Discuss results (written report)
- refer for individualized interventions and community-based services if not already done
- provide fam support
Recommended interval between ASD dx referral and assessment?
3-6 mos
3 key objectives of ASD assessment?
1-provide categorical dx of ASD
2-explore ddx/co-morbidities
3-determine overall level of adaptive functional and personal interests
8 major elements of ASD dx assessment
- records review
- interviewing parents, fam members, other caregivers
- assessment for core features of asd
- comprehensive phys exam and additional investigations
- consider ddx and comorbitidies
- establish the dx
- communicate the dx findings
- comprehensive assessment for intervention planning
can findings from an ASD dx assessment tool be used alone to dx ASD?
No; they must complement the dx process
Which ASD dx tool is most sensitive
ADOS (also same specificity as CARS and ADI-R)
GIve 2 ASD dx tools based on interacting with child
ADOS-2, CARS-2
Give 2 ASD dx tools based on not interacting with child
ADI-R; SRS-2
also: DISCO, 3di
Which ASD dx tools can be used under age 2?
ADOS-2 (12 mos-adult); DISCO (any age)
Which ASD dx tool takes the shortest time? The longest?
Shortest: SRS2 (15-20 min); longest ADI-R adn DISCO (up to 3 hours)
Give 5 elements of phys exam for ASD
- ht and wt
- HC
- Skin exam for signs of NF1, TS (eg using wood’s lamp)
- neuro exam
- cong anomalies and dysmorphic features (large and prominent ears)
2 investigations should be done for all kids undergoing ASD assesment?
hearing and vision assessment (with referral to audiology and ophtho/optometry)
Give 5 tests to order for ASD if needed
EEG MRI metabolic testing chrom microarray blood lead levels
Give 4 neurodev d/o’s that are in ddx for ASD
ADHD GDD/ID Language or learning d/o social communic d/o stereotypic movement d/o tourette's d/o or tic d/o
Give 4 mental/behav d/os in ddx for ASD
anxiety d/os CD Selective mutism OCD ODD
Also: depresive d/o's disruptive mood dyreg d/o Reactive attachment d/o Schizophrenia
Give 2 genetic conditions in ddx for ASD
Fragile X sydrome
Rett Syndrome
Other genetic variants (16p11)
Give 4 neuro/other med conditions in ddx for ASD
CP Epilepsy Mitochondrial d/os Neonatal encephalopathy Landau-Kleffner syndrome
ASD is diagnosed __ x more frequently in boys
4
3 groups likely to have a later dx for ASD?
girls, minorities, children living in rural areas
7 approaches to post-dx ASD management?
- Test for associated med conditions
- assess/managed co-morbidities
- other therapies that address ASD_associated functioning
- Behav/dev interventions
- manage challenging behaviours
- CAM approaches
- Family and other support interventions