CPM Written Exam Flashcards
What makes the cornea clear?
Wavelength of visible light is approx 500nm
Collagen fibrils are closely and regularly spaced (60nm)
As long as the distance bw collagen fibrils is < 200 light will be transmitted and not scattered
Emetropia
Light is focused right on the retina = a perfect image
Myopia
Image is focused in front of the retina
=nearsightedness
Hyperopia
Image is focused behind the retina
=farsightedness
Shape of the lens when the ciliary muscle is relaxed:
Lens is flattened, more pancake-like
Shape of the lens when the ciliary muscle is contracted:
Lens is rounder, more spherical-like
Order of leading causes of blindness in the US:
- Macular degeneration
- Glaucoma
- Diabetic retinopathy
- Cataracts
Cotton wool spots
Areas of hemorrhage in the retina; seen in diabetic retinopahy
Background diabetic retinopathy - fundoscopy:
Hemorrhages (“cotton wool spots”)
Lipid deposits in macula
Background diabetic retinopathy - pathophysiology:
The vessels of the retina become leaky in diabetes -> serum leaks out of vessels, and serum is high in lipid content so you get lipid deposits as well. Basically you see aneurysms, hemorrhages, edema, lipid deposits.
Proliferative diabetic retinopathy - fundoscopy:
See neovascularization now. But these new vessels are abnormal, immature, leak fluid and bleed, grow in abnormal places & patterns.
Proliferative diabetic retinopathy - pathophysiology:
The capillaries become so damaged that they shut down –> photoreceptors die –> as they die they release VEGF, which causes the neovascularization
Macular degeneration - pathophysiology:
RPE not able to efficiently process the metabolic byproducts of phototransduction –> they build up as drusen (yellow blobs seen in the macula). Over time RPE cells become even more dysfunctional and they die, and when they die corresponding photoreceptors die too –> so see large areas of atrophy in severe MD. In wet-type, neovascularization occurs (similar to diabetic retinopathy)
Risk factors for macular degeneration - dry type:
Mutations in complement factor H pathway Smoking Hyperopia Light iris color Hypertension, hypercholesterolemia Cardiovascular disease Female
Natural history of wet age-related macular degeneration:
Blood vessels close down and become fibrovascular –> basically you end up with one big sheet of scar tissue
Macular degeneration - dry type, treatment:
Vitamins & minerals: ascorbate, vitamin E, vitamin A, zinc, selenium, lutein, zeaxanthine
Macular degeneration - wet type, treatment:
Laser
Low powered laser + hematoporphyrin derivative (PDT) (Visudyne)
VEGF inhibitors (Lucentis, avastin)
Corticosteroids (Triamcinolone)
Which cells produce aqueous humor?
Nonpigmented cells of ciliary body epithelium
Glaucoma treatment:
Decrease aqueous production: beta-blockers, alpha-agonists, carbonic anhydrase inhibition
Increase aqueous outflow: prostaglandin analogs, atropine, pilocarpine
Laser & surgical
S1:
Mitral valve closes before tricuspid, but still heard as one sound
Best heard in mitral area
S1 louder in:
High cardiac output
Mitral stenosis
Atrial myxoma
S1 softer in:
Low cardiac output
Tachycardia
Obesity
S1 variable intensity in:
Certain arrhythmias with a variable HR
Best area to hear aortic component of S2:
It’s loud and heard everywhere, but often best in 2nd RICS
Best area to hear pulmonic component of S2:
It’s soft, and only heard in 2nd LICS
S2 split:
Aortic closes before pulmonary, and this split is wider during inspiration.
best heard at left second intercostal space
Wide, fixed split of S2:
ASD (equalization of pressures bw right and left sides)
Paradoxical split of S2:
Aortic component of S2 occurs after pulmonic AND split is wider on expieratino than inspiration –> due to a delay in aortic component –> due to LBBB, HTN, aortic stenosis, etc.
Loud S2:
Hypertension
Dilated aortic root
Soft S2
Calcific aortic stenosis
Loud P2
Pulmonary hypertension
S3
From rapid filling phase of diastole
Occurs w/ dilated LV (HF) or increased flow into LV (MR, AI)
Best heard at apex in LLD position
S4
From atrial systole phase of diastole
Occurs w/ stiffened or thickened LV (AS, htn, HF)
Best heard at apex in LLD position
Opening snap
From mitral valve opening
Occurs w/ mitral stenosis (often from RF)
High pitched sound best heard with diaphragm
Heard after S2
Neck veins - waves & descents
A wave - atrial contraction
X decent - atrial relaxation and descent of base of RA
C wave - bulging of tricuspid valve into RA during isovolumetric contraction
X descent (2nd part): continued atrial relaxation
V wave - from filling of the atrium during systole (w/ tricuspid valve closed)
Y descent - from opening of tricuspid valve
Visceral abdominal pain
Dull, crampy, aching Poorly localized Bilateral autonomic innervation Slow C fibers Perceived in midline Embryologic distribution
Somatic abdominal pain
Involvement of parietal peritoneum Severe and localized Ipsilateral Somatic innervation (spinal nerves) A-delta fibers (rapid transmitters)
Onset of abdominal pain
Immediate - peritonitis, usually surgical
Intermediate (developing over hours) - cholecystitis, appendicitis
Delayed (over days) - obstruction, ileus
Colicky pain
Comes in waves/paroxysms
Ex. from kidney stone (shows up well on plain xray btw), intussuception (can see on xray w/ barium enema)
Aortic dissection
Severe crushing chest pain
Ulcer
Burning epigastric pain
Food relieves pain for duodenal ulcer, but aggravates pain in gastric ulcers
Abdominal pain radiation
Pain is present at site away from point of origin, but still at original site too. (vs. migration)
Ex. ureteric colic (kidney stone) radiates to grown, pancreatic pain radiates to the back
Abdominal pain migration
Pain at site away from the point of origin, which has now subsided
Signifies involvement of overlying peritoneum
Ex. RLQ pain in appendicitis, infarction in small intestine with migrating localized pain
Abdominal referred pain
Dermatomes!
Ex. periumbilical pain in early appendicitis, gall bladder pain to angle of scapula
Bowel sounds - missing v. hyperactive
Peritonitis - no bowel sounds
Ileus - hyperactive bowel sounds
Abdominal discoloration
Grey turner sign - Flank ecchymosis (bruising)
Cullen sign - Umbilical ecchymosis
Abdominal red flags
fever, vomiting, syncope, blood loss, altered mental status, tachycardia, pain that is out of proportion to PE (bowel infarct)
Appearance of abdominal pt - restless v. lying still
restless - colicky pain, ureteric colic, biliary colic
Lying still - peritonism/peritonitis, blood, bile or pus
Distension v. abdominal pain
Ileus - distention without pain
Acute intestinal obstruction - abdominal pain followed by distention
Borbyrigmy
A quality of bowel sound - from food and liquid being pushed in the bowel agianst bowel wall
a rumbling or gurgling noise that occurs from the movements of fluid and gas in the intestines
Succession splash
seen in gastric outlet obstruction
move pt back and forth and can hear water swishing inside
(pt must have not eaten for at least 3 hours)
Abdominal percussion
tympanic - gas
dull - fluid (ascites or blood)
percussion is a very sensitive sign of peritonitis
Ascites, associated findings:
caput medulla
spider angioma
Left supraclavicular lymph node
AKA Virchow’s node
= Troisier’s sign
Gastric cancer travels up to here through the thoracic duct
Conditions mimicking a acute abdomen
acute MI/angina, pericarditis, pneumonia, acute hepatitis, herpes zoster, abdominal wall hematoma, ureteral obstruction, pyelonephritis, sickle cell crisis, DKA, pophyria, leukemia
Appendicitis
periumbilical pain –> RLQ pain
pt most comfortable lying still
moderately severe, steady pain
Associated appetite loss & vomiting
Pancreatitis
Pain radiates to back
pain is less severe when sitting up & leaning forward but is worse lying down
Pain onsets suddenly (while eating fatty food), is sharp/knife-like quality and very severe
Associated vomiting
Cholecytitis
pain in upper abdomen –> RUQ; radiates to inf angle of scapula
Pt most comfortable lying still
Onset while eating fatty food
Associated nausea and vomiting
Kidney stone (renal colic)
pain in posterior subcostal region on affected side & radiates to groin
colicky type pain - pt is restless
pain onset very suddenly & very severe
associated urinary urgency & frequency
Elderly pt with abdominal disease
high likelihood of surgical disease
Appendicitis, pearls:
Consider in all pts with abdominal pain and an appendix, esp in pts with the presumed diagnosis of gastroenteritis, PID or UTI
WBC count is of little clinical importance in a pt with possible appendicitis
A pt with appendicitis by hx and PE doesn’t need a CT scan to confirm the dx, they need an operation
What are the 4 ethical principles?
autonomy
nonmaleficence
beneficence
justice
Nonmaleficence
Do no harm, avoid harm, prevent harm
Autonomy
the ability to understand medical information and to relate this to one’s life plan and priorities
Beneficence
act in such a way as to provide a benefit for the patient
Justice
Give to each that which is due
Anesthesia
complete loss of touch appreciation
Hypesthesia
decreased appreciation touch
Hyperesthesia
increased sensitivity to touch
Analgesia
complete loss of pain appreciation
hypalgesia
decreased appreciation of pain
hyperalgesia/hyperpathia
increased sensitivity to pain
dysesthesia/allodynia
misperception of trivial tactile sensation as pain
paresthesia
abnormal spontaneous sensation such as tingling, pins and needles, or burning sensation
agnosia
the inability to recognize one or more classes of environmental stimuli, even though the required intellectual and perceptual functions are intact
anosognosia
inability to recognize one’s own impairment
Romberg test
positive if unsteadiness is markedly increased by eye closure
indicates gross impairment of joint position in the lower extremities
2 point discrimination
impaired side will have increased threshold for 2 point discrimination (the stimuli will have to be further apart)
if peripheral sensory function is intact, impaired 2 point discrimination suggests a disorder of the contralateral sensory cortex
Flat lesion, <1cm
macule
Flat lesion, >1cm
patch
Raised lesion, <1cm
papule
Raised lesion, >1cm
plaque
Fluid filled lesion, <1cm
vesicle
Fluid filled lesion, >1cm
bulla
nodule
nodule is deeper (papule is more superficial), can feel under the skin
nodule doesn’t have size description
pustule
filled with pus
tends to be small lesion but not defined by size
a little more superficial
obstructed breathing
slow breathing, prolonged inspiratory
COPD, asthma
restricted breathing
small tidal volume, rapid rate
restrictive lung diseases
kussmaul’s breathing
abnormally large tidal volume and usually little apparent effort
metabolic acidosis, during exercise
cheyne-stokes respiration
Normal: infants, healthy elderly, high altitude
Abnormal: increased ICP, uremia, coma, respiratory depressant use, CHF, obstructive sleep apnea
leaning forward (breathing)
helps you exhale
if you see leaning forward breathing, they may have heart failure
purse-lip breathing
causes increased end-expiratory pressure
splints open airways and keeps alveoli open
Chest expansion
with COPD and lung disease it will move less
pneumothorax - one side will move more than the other
Tactile fremitus
increased with consolidation
decreases in areas without air
Percussion
areas with air - resonant
areas without air - dull
tracheal breath sounds
tracea area, loud, high-pitched
vesicular breath sounds
most lung tissue, soft, low-pitch
Bronchial breath sounds
manubrium area, loud, high pitched
abnormal if you hear this in the periphery
bronchovesicular breath sounds
1st/2nd ICS ant/post area, intermediate intensity and pitch
rales (crackles)
small airways open during inspiration and collapse on expiration, or air bubbles through secretions
Wheeze
high pitched sound when air flows through narrowed airways
rhonchi
low pitch sound, larger airway obstructed due to secretions
stridor
inspiratory wheeze heard loudest over trachea
pleural rub
creacking sounds when inflamed pleura rub against each other
mediastinal crunch
aka hamman’s sign
crackles heard in the chest synchornized with heart beat
from air in mediastinum
egophony
e to a in consolidated lung
fluid in lung transmits voice sounds loudly to the lung periphery
whispered pectoriloquy
increased sound with whispered voice if consolidated
Cor pulmonale
peripheral edema jugular venous distension pulmonary rales cardiac S3 hepatojugular reflex
effusion - findings
decreased or absent breath sounds
dull to percussion
decreased fremitus
consolidations
bronchial breath sounds
dull to percussion
increased fremitus
egophany present