CPM Written Exam Flashcards
What makes the cornea clear?
Wavelength of visible light is approx 500nm
Collagen fibrils are closely and regularly spaced (60nm)
As long as the distance bw collagen fibrils is < 200 light will be transmitted and not scattered
Emetropia
Light is focused right on the retina = a perfect image
Myopia
Image is focused in front of the retina
=nearsightedness
Hyperopia
Image is focused behind the retina
=farsightedness
Shape of the lens when the ciliary muscle is relaxed:
Lens is flattened, more pancake-like
Shape of the lens when the ciliary muscle is contracted:
Lens is rounder, more spherical-like
Order of leading causes of blindness in the US:
- Macular degeneration
- Glaucoma
- Diabetic retinopathy
- Cataracts
Cotton wool spots
Areas of hemorrhage in the retina; seen in diabetic retinopahy
Background diabetic retinopathy - fundoscopy:
Hemorrhages (“cotton wool spots”)
Lipid deposits in macula
Background diabetic retinopathy - pathophysiology:
The vessels of the retina become leaky in diabetes -> serum leaks out of vessels, and serum is high in lipid content so you get lipid deposits as well. Basically you see aneurysms, hemorrhages, edema, lipid deposits.
Proliferative diabetic retinopathy - fundoscopy:
See neovascularization now. But these new vessels are abnormal, immature, leak fluid and bleed, grow in abnormal places & patterns.
Proliferative diabetic retinopathy - pathophysiology:
The capillaries become so damaged that they shut down –> photoreceptors die –> as they die they release VEGF, which causes the neovascularization
Macular degeneration - pathophysiology:
RPE not able to efficiently process the metabolic byproducts of phototransduction –> they build up as drusen (yellow blobs seen in the macula). Over time RPE cells become even more dysfunctional and they die, and when they die corresponding photoreceptors die too –> so see large areas of atrophy in severe MD. In wet-type, neovascularization occurs (similar to diabetic retinopathy)
Risk factors for macular degeneration - dry type:
Mutations in complement factor H pathway Smoking Hyperopia Light iris color Hypertension, hypercholesterolemia Cardiovascular disease Female
Natural history of wet age-related macular degeneration:
Blood vessels close down and become fibrovascular –> basically you end up with one big sheet of scar tissue
Macular degeneration - dry type, treatment:
Vitamins & minerals: ascorbate, vitamin E, vitamin A, zinc, selenium, lutein, zeaxanthine
Macular degeneration - wet type, treatment:
Laser
Low powered laser + hematoporphyrin derivative (PDT) (Visudyne)
VEGF inhibitors (Lucentis, avastin)
Corticosteroids (Triamcinolone)
Which cells produce aqueous humor?
Nonpigmented cells of ciliary body epithelium
Glaucoma treatment:
Decrease aqueous production: beta-blockers, alpha-agonists, carbonic anhydrase inhibition
Increase aqueous outflow: prostaglandin analogs, atropine, pilocarpine
Laser & surgical
S1:
Mitral valve closes before tricuspid, but still heard as one sound
Best heard in mitral area
S1 louder in:
High cardiac output
Mitral stenosis
Atrial myxoma
S1 softer in:
Low cardiac output
Tachycardia
Obesity
S1 variable intensity in:
Certain arrhythmias with a variable HR
Best area to hear aortic component of S2:
It’s loud and heard everywhere, but often best in 2nd RICS