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CPE Review > CPE Review > Flashcards

CPE Review Flashcards

1
Q

Lithium teratogenicity:

A

heart valve defects

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2
Q

carbamazepine teratogenicity

A

spina bifida, craniofacial problems, decreased birth weight

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3
Q

valproic acid teratogenicity

A

spina bifida

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4
Q

paroxetine teratogenicity

A

heart malformation - small risk

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5
Q

therapeutic drug level of valproic acid

A

50 -100 mcg/ml

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6
Q

carbamazapine therapeutic drug level

A

4-14 mcg/ml

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7
Q

nortriptyline therapeutic drug level

A

50-150 ng/ml

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8
Q

what is the composition of methylphenadate LA?

A

50:50 mix IR:CR

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9
Q

how does methylphenadate work?

A

It blocks DA and NE reuptake

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10
Q

guanfacine and CYP:

A

CYP 3A4 substrate

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11
Q

clonidine and CYP

A

CYP 2D6 substrate

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12
Q

is guanfacine or clonidine more potent?

A

clonidine

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13
Q

what would be a good first line therapy for the kid who has the 2D6 issues and ADHD?

A

Methylphenadate Oros 27 mg (Concerta)

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14
Q

which ADHD medication is a prodrug?

A

Vyvanse (lisdexamphetamine)

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15
Q

list three opioids that are safe in renal insufficiency

A

fentanyl, oxycodone, methadone

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16
Q

Ibuprofen dosing in children over 6 months:

A

5-10 mg/kg q 6-8 hours

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17
Q

ibuprofen dosing in 12+ years

A

200 mg q 4-6 hours

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18
Q

dosing of ibuprofen for a 46 pound child

A

150 mg q6 hours

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19
Q

what drug would you use for neuropathic pain if the patient has hypertension?

A

pregabalin

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20
Q

how long to relieve diabetic neuropathic pain?

A

4 weeks

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21
Q

which opioid has the longest half life?

A

methadone

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22
Q

NPO patient with Crohn’s, what would you give?

A

IV Ketorolac

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23
Q

Emilia broke her hip and doesn’t want more narcotics

A

give APAP

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24
Q

what opioid can you give a patient with a true morphine allergy?

A

fentanyl

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25
Q

what type of drug is first line prophylaxis for migraines?

A

beta blockers

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26
Q

if you have migraines with comorbid seizure or bipolar, give

A

VPA/ TOP

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27
Q

If you have migraines with comorbid depression, give

A

TCA

28
Q

what are contraindications for using triptans?

A

ischemic heart condition, MI, cerebrovascular issues

29
Q

how would you treat a migraine with light sensitivity?

A

sumatriptan

30
Q

what is the mechanism of action of methotrexate?

A

inhibits folic acid metabolism

31
Q

if a patient is taking methotrexate and sulfasalazine, what else should you add on?

A

folic acid

32
Q

should NSAIDs be used alone in RA?

A

no, as a bridge to DMARD therapy

33
Q

what is important to consider when a patient is on zolendronic acid?

A

check serum creatinine levels

34
Q

what is the definition of fever in children?

A

100.4

35
Q

why is paroxetine class D?

A

heart malformations

36
Q

what is the max dose for paroxetine?

A

60 mg

37
Q

which trial was inadequate?

A

sertraline 50 mg - can go up to 200 mg

38
Q

what is not a common side effect of SSRIs?

A

orthostatic hypotension

39
Q

what antidepressant doesn’t cause weight gain, but can cause weight loss instead?

A

bupropion

40
Q

what augmentation therapy can you use for MDD?

A

lithium

41
Q

when is it OK to get off of seizure meds?

A

control within one year of seizure onset

42
Q

what tests do you order for patient on VPA?

A

AST/ASL

43
Q

how do you initiate lamotrigine therapy if no other antiseizure meds?

A

25 mg/ day

44
Q

how do you initiate lamotrigine therapy if patient is on valproate?

A

25 mg every other day

45
Q

how do you initiate lamotrigine therapy if patient is on carbamazapine?

A

50 mg/ day

46
Q

interaction between OCPs and lamotrigine?

A

OCP lower lamotrigine levels by 50%

47
Q

how do you convert from carbamazepine to oxcarbazapine?

A

1.5 carb: 1 oxcarb

48
Q

carbamazapine black box warning:

A

SJS, TEN. Agranulocytosis

49
Q

lamotrigine black box warning

A

SJS

50
Q

subtherapeutic dose of valproate can be bumped up to how much?

A

1000 mg/day

51
Q

nortriptyline CYP

A

2D6 substrate

52
Q

paroxetine CYP

A

2D6 substrate and inhibitor

53
Q

name a drug that is a 1A2 inducer

A

caffeine

54
Q

if someone is allergic to sulfasalazine, they would have a reaction to

A

Bactrim

55
Q

what antibodies are responsible for type I hypersensitivity reactions?

A

IgE

56
Q

how to rechallenge sulfonamides?

A

don’t, they can cause serum sickness

57
Q

how to rechallenge penicillin?

A

graded challenge or desensitization

58
Q

which vaccine is contraindicated in pregnancy?

A

Varicella

59
Q

absolute risk of not having problems with drug X 5% and drug Y 20%

A

75% and statistically significant

60
Q

which parkinson’s treatment should not be used alone?

A

entacapone (COMT), should be used with levodopa

61
Q

what do you give a patient on levodopa/carbidopa for wearing off symptoms?

A

entacapone

62
Q

name a drug that could exacerbate parkinson’s symptoms

A

chlorpromazine or prochlorperazine

63
Q

which drug is not adjunctive with paroxetine?

A

venlafaxine - both are 2D6

64
Q

what type of hypersensitivity reaction is hives?

A

Type I (TH2)

65
Q

what type of hypersensitivity reaction is puritis?

A

type IV (TH1), delayed type

CPE Review (1 decks)

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