COVID-19 Flashcards

1
Q

What family of viruses does COVID-19 belong to?

A

Coronaviruses
A large family of viruses including
- SARS: severe acute respiratory syndrome
- MERS: middle eastern respiratory syndrome
- Seasonal coronavirus

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2
Q

What are the features of coronaviruses?

A

Crown like spikes on the surface
Enveloped RNA based

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3
Q

Who can coronaviruses infect?

A

Humans and animals
(is zoonotic = large number circulating in animals)

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4
Q

What are the different types of coronaviruses?

A

Alpha - related to bats
Beta - related to bats (COVID-19)
Gamma - related to birds
Delta - related to pigs

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5
Q

What was the initial and intermediate hosts for COVID-19 (and other coronaviruses)?

A

Initial host = bats
Intermediate = don’t know!
- MERS = camel
- SARS = cats

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6
Q

How is COVID-19 transmitted?

A

Cough
Sneeze
Touch

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7
Q

How does coronavirus attack/infect the body?

A
  1. Enter nose/respiratory tract
  2. Use binders on human cells to enter
  3. Hijack enzymes and replicate virus protein
  4. Package it up
  5. Leave cell to infect more cells
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8
Q

How does the immune system respond?

A

Via T and B cells
T cells = direct attack
B cells = memory attack

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9
Q

How long can COVID-19 survive on certain surfaces?

A
  • Copper = 3
  • Copper = 4
  • Cardboard = 24
  • Steel = 48
  • Plastic = 72
  • Glass = 96
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10
Q

Define the term epidemic

A

Refers to an increase, often sudden, in the number of cases of a disease above what is normally expected in that population in that area.
e.g. Ebola

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11
Q

Define the term endemic

A

Refers to the constant presence and/or unusual prevalence of a disease/infectious agent in a population within a geography area.
e.g. malaria

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12
Q

Define the term outbreak

A

Carries same definition of epidemic but is often used for a more limited geographic area.
e.g. cholera

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13
Q

Define the term pandemic

A

Refers to an epidemic that has spread over several countries or continents usually affecting a large number of people.
e.g. COVID-19

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14
Q

What are variants of interest?

A

Genetic traits which predict
- Greater transmissibility
- More severe disease
- Evasion of immune system or testing

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15
Q

What are variants of concern?

A

Observed to
- Have increased transmissibility
- Cause more serious infection
- Cause reinfection or infection of immunised

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16
Q

What are variants of high consequence?

A

No protection from vaccines

17
Q

What are the symptoms of COVID-19?

A

Rhinorrhoea - runny nose
General malaise
Headache
Fever
Cough
Sore through
And lots of others

18
Q

What is a complication of COVID-19 and what are its signs?

A

Pneumonitis
- Inflammation of the lung
- CXR: white patches throughout the lung

19
Q

What are the main tests used to identify COVID-19?

A

LFT
PCR
Antibody test

20
Q

What are the benefits of LFT and how does it work?

A

Looks for antigens to see if you have the condition

Benefits:
- Simple to use
- Good when you have a high viral load (early in condition
- Cheap
- Fast result

21
Q

What are the disadvantages of LFT?

A
  • When you have a high viral load there’s usually no/minimal symptoms so not likely to do a test.
  • Can give false -ve
22
Q

How does PCR work and list some benefits?

A

Looks for protein of COVID-19 and amplifies it until visible.

Benefits
- Can detect protein throughout the whole illness

23
Q

What are some disadvantages of PCR?

A

Slower (6 hours at best)
Expensive
Can pick up dead virus (which is non-transmissible)

24
Q

Who was the antibody test used on?

A

Used to look at immunocompromised patients (people with cancer etc.)
No longer used in practice

25
Q

What types of treatment are available for COVID-19 patients?

A

Supportive
Anti-inflammatory
Anti-viral

26
Q

What types of supportive treatments are used?

A

Oxygen
Fluids
Paracetamol

27
Q

What types of anti-inflammatory treatments are used?

A

Steroids
Baricitinib
Tocilizumab
- Only evidence for working on very sick patients who have high markers of inflammation in their blood.

28
Q

What types of anti-viral treatments are used?

A

Remdesivir
Paxlovid

29
Q

What does immunisation do?

A
  • Expose body to parts of the virus so you can build an immune response and memory for future infection.
  • Reduced chance of infection
  • Reduced chance of death
30
Q

What are some possible complications of COVID-19?

A

Thrombosis
Post COVID syndrome (long COVID)

31
Q

Explain thrombosis in relation to COVID.

A

Infection causes inflammation, narrowing blood vessels and leading to blockages and thickening of the blood, this leads to clots.
Incidence
- Deep vein thrombosis - 11.8%
- Pulmonary embolism - 7.8%
Treatment
- Blood thinning medication
Prevention
- Keep active/moving

32
Q

Explain post COVID syndrome in relation to COVID.

A

Consistent symptoms for 3 months after covid diagnosis that can’t be explained by something else (another illness/virus).

33
Q

Who is at risk of long COVID?

A

Elderly/very young
Females
Minority ethnic groups
The obese
Smokers
Severe clinical status (underlying health conditions)

34
Q

What are the symptoms of long COVID?

A

Persistent cough
Low grade fever
Fatigue
Myalgia
Palpitations
Headache

35
Q

How do you treat long COVID?

A

No drugs/treatments
Advice is to slowly build up activity and usual daily activities
Treat symptoms with paracetamol

36
Q

What is heard immunity?

A

The resistance to the spread of an infectious disease within a population that is based on pre-existing immunity of a high proportion of individuals as a result of previous infection or vaccination.