Coupled G Proteins Flashcards
1
Q
b1
A
Gs
2
Q
M2,4
A
Gi
3
Q
Gq downstream effects
A
Stimulates PLC -> cleaves PIP2 into IP3 + stimulates DAG and PKC -> stimulates Ca++ influx
Causes smooth muscle contraction
4
Q
a1
A
Gq
5
Q
M1,3,5
A
Gq
6
Q
Gi downstream effects
A
Inhibits AC, remaining cAMP degraded by PDEs
activates GIRK (in heart) -> K+ outflow -> repolarization
7
Q
Gs downstream effects
A
Activates AC -> increase cAMP -> increase PKA -> activate Ca++ channels
Causes heart muscle contraction Causes bronchodilation (relaxation)
8
Q
b2
A
Gs
