Cough and COld

Question 1

Common Cold Classes

Answer 1

• Antihistamines, Antipyretics, Analgesics
• Cough suppressants
• Mucoactives
• Nasal Decongestants

Fat mixture

Question 2

Antitussives

Answer 2

Opiates

• Opoids: Codeine (then morphine), Hydrocodone
• mu opioid receptors in brain

Non-narcotic codeine analog: Dextromethorphan DM
MOA: - binds NMDA, then activate Sig1-R on Endoplasmic Reticulum ER

Question 3

Mucoactives

Answer 3

Mucous Thinning, decrease viscosity
Expectorants: cough stimulating
Mucokinetic: increase transport
Mucoregulators: decrease secretion

Overall decrease mucous accumulation, improve obstruction

Mucolytics:

• N-Acetylcysteine
• Carbocisteine

Expectorant
- Guaifenesin

Mucoregulator: M for MUCOUS

• M3 blocker ipratropium bromide (block inflammation induced mucous) - also bronchodilation
• • M3 for lungs
• Macrolides

Mucokinetics - BETA AGONISTS, salbutamol, salmeterol

Question 4

Decongestants

Answer 4

alpha agonists - vasoconstriction

- phenylephrine (alpha only), pseudoephedrine (mixed alpha and beta)

Question 5

Whats atropine

Answer 5

Muscarinic blocker

- given w Diphenoxylate, Opioid, treat diarrhea tgt w Loperamide

Question 6

Name the opioids for cough
Opioids for Diarrheas’
Opioid blocker

Answer 6

Codeine (morphine), Hydrocodone
- anti coughs

dextromethorphan DTMTP
- non addicting

Loperamide
Diphenoxylate (+ atropine)

Methylnaltrexone Bromide

Question 7

Name the expectorant

Answer 7

Guaifenesin GUAI and SIN and FENE

Question 8

Mucokinetics

Answer 8

Beta agonistis

• SABA - salbutamol
• LABA - salmeterol

Question 9

Mucolytics

Answer 9

N-acetylcysteine NAC

Carbocisteine CBC

Question 10

Mucous Regulators

Answer 10

Muscarinic Blockers
- Ipratropium Bromide

Macrolides

Question 11

Name all antihistamines including Claritin

Answer 11

Loratidine + Phenylephrine
antihistamine + alpha agonist

Diphenhydramine - M1, H1 block @ Vestibular, VC

Cimetidine, Femotidine - Acid block - H2