COSHH for Isolation and derivatisation of Eugenol

Question 1

list the substances that are classified as harmful or irritant:

what is the volume/concentration in which they are used?

Answer 1

(1) Eugenol: v/c = 0.5g
(2) Pyridine: 20 cm3
(3) Dichloromethane: 20 cm3
(4) Solvent-Chloroform and Methanol: 10 cm3
(5) Diethyl ether: 80 cm3
(8) Hydrochloric acid: 6M, 5-7 cm3

Question 2

how is eugenol harmful?

Answer 2

Harmful if swallowed-avoid

contact with eyes and skin

Question 3

how is Pyridine harmful?

Answer 3

Harmful by inhalation, in
contact with skin and if
swallowed

Question 4

how is Dichloromethane harmful?

Answer 4

Possible risk of irreversible effects. Avoid contact with skin and eyes. Carcinogenic, possibly mutagenic and teratogenic

Question 5

how is Solvent-Chloroform and Methanol harmful?

Answer 5

Possible risk of irreversible effects. Avoid contact with skin and eyes. Carcinogenic, possibly mutagenic and teratogenic

Question 6

how is Diethyl ether harmful?

Answer 6

Harmful if swallowed

Question 7

how is Hydrochloric acid harmful?

Answer 7

Irritant to eyes, skin and respiratory system

Question 8

list the substances that are classified as Corrosive:

what is the volume/concentration in which they are used?

Answer 8

(6) 4-Chlorobenzoyl chloride: 2g

(12) Sodium Hydroxide: 5%

Question 9

what makes 4-Chlorobenzoyl chloride corrosive?

Answer 9

Causes burns. Irritating to eyes and respiratory system

Question 10

what makes Sodium Hydroxide corrosive?

Answer 10

Causes severe burns

Question 11

list the substances that are classified as toxic?

what is the volume/concentration in which they are used?

Answer 11

(9) Derivative of Eugenol: n/a

(7) Methanol: 50 cm3

Question 12

what makes Derivative of Eugenol toxic?

Answer 12

Toxicity unknown, assume to be toxic

Question 13

what makes Methanol toxic?

Answer 13

Danger of very serious irreversible effects
through inhalation, skin contact and if
swallowed

Question 14

list the substances that are classified as non hazardous?

what volume or concentrations are they used?

Answer 14

(10) Sodium sulphate anhydrous: 1g

(11) Clove oil: 2ml

Question 15

what methods of disposal for each reagents are used in the lab?

Answer 15

Waste bin

Sharps bin

Sink and flush with water for:

(8) Hydrochloric acid
(11) Clove oil
(12) Sodium Hydroxide

Organic waste must be put in
appropriate waste Solvent bottles
(3) Dichloromethane
(4) Solvent-Chloroform and Methanol
(5) Diethyl ether
(7) Methanol

Biohazard bag

Glass bin for Uncontaminated
broken glass

Glassware to be
rinsed prior to
placing in wash tubs