Corynebacterium Diphtheriae

Question 1

Characteristics of Diphtheriae

Answer 1

● Gram (+ve) bacilli

● Non-spore forming

● Catalase (+ve)

● Chinese letter-like shape
Aerobes and facultative

Question 2

➢Pathogenesis Diphtheriae

Answer 2

• Invasion and colonization (pyogenic) Pseudomembrane
• Toxin production (toxigenic)

Question 3

tropism of Corynebacterium Diphtheriae exotoxin is to:

Answer 3

1. Heart
2. Central nervous system

Question 4

Characterized of
Nasopharyngeal Diphtheria:

Laryngeal Diphtheria

Answer 4

1.
cervical lymphadenopathy
♦️bull neck
2. ● High rate of toxaemia
● Part of the pseudomembrane (suffocation)

معظم الشفع الي بموتو بالدفتیریا بكون بسبب ال suffocation

Question 5

Clinical features of Diphtheria case

Answer 5

1. Low-grade fever and Sore throat
2. After 1-2 days, Pseudomembrane (symptoms of toxaemia)

Complications:

1. Cardiovascular complications

● Mainly myocarditis اكتر حاجة بتقتل الكبار

2. CNS complications

● Dysphagia ● Dysphonia ● Diplopia

Drop Neck هو طبعاً بضرب كذا نيرف بس دا اهم حاجة

Question 6

➢Virulence Factors Diphtheriae

Answer 6

Active (A) Subunit ADP-ribosylation of elongation factor-2 (eF-2), inhibiting protein synthesis

Binding (B) Subunit

Question 7

The production of toxin is determined by in Diphtheriae

Answer 7

1. Lysogenization by B-phage
2. Concentration of iron in the media

If iron concentration is high the bacteria is not toxigenic