corynebacterium diphteriae Flashcards

1
Q

características de corynebacterium
* forma, gram
* aer/anaer

A
  • bacilo gram + en bastón
  • anaerobia facultativa
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2
Q

dónde coloniza el corynebacterium?

A
  • piel
  • t. digestivo
  • t. resp
  • t. uri
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3
Q

en donde es ubicua la corynebacterium?

A

plantas y animales

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4
Q

las corynebacterium producen esporas?

A

no

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5
Q

cuantos biotipos hay de corynebacterium?

A

4

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6
Q

principal factor de virulencia de corynebacterium

A

toxina diftérica

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7
Q

qué hace la toxina A-B?

A

se une al fact crecimiento epidérmico d unión a la heparina

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8
Q

qué inhibe la toxina A-B?

A

inhibe síntesis proteíca al inactivar el EF-2

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9
Q

cuál es el único reservorio de corynebacterium?

A

humano

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10
Q

tipos de difteria

A
  • respiratoria
  • cutánea
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11
Q

como es la fase aguda de la difteria respiratoria?

A
  • faringitis pseudomembranosa
  • invade laringe
  • sangrado al desprenderse
  • ES LA + PELIGROSA
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12
Q

qué sigue dsp de la fase aguda de la difteria respiratoria? y cuánto tiempo después sucede?

A
  • miocarditis
  • neuropatía
    (1-2 semanas después)
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13
Q

tx de la difteria

A
  • antitoxina antidiftérica
  • penicilina
  • proteger vía aérea
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14
Q

l

la difteria genera inmunidad?

A

no

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15
Q

cómo funciona la vacuna toxoide para la difteria?

A

suero antitoxina, Ig antitoxina
para que se produzca Ac contra la toxina

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16
Q

gen que codifica la toxina A-B

A

gen tox

17
Q

cómo se transmite la difteria?

A

gotas (persona-persona)
portadores pueden ser asintomáticos

18
Q

cómo se manifiesta la difteria cutánea?

A

úlcera crónica