Corynebacterium diphteriae Flashcards

1
Q

Metabolismo

A

Anaerobio facultativo

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2
Q

Gram

A

Positivo

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3
Q

Movimiento

A

Inmóvil

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4
Q

Esporulación

A

No esporula

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5
Q

Toxinas y virulencia

A
Toxína diftérica (principal factor de virulencia)
Toxina A-B codificada
por gen tox
El receptor para la
toxina es el factor de crecimiento
epidérmico de unión
a la heparina.
La toxina inhibe la síntesis proteíca de
las células
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6
Q

Enfermedades

A
  1. Difteria respiratoria
    - Faringitis pseudomembra-
    nosa
    - Puede invadir laringe
    - Sangrado al desprenderse 1-2 semanas, después mio- carditis y neuropatía.
  2. Difteria cutánea
    - Úlceras crónicas que no cicatrizan
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7
Q

Tratamiento

A
  • Antitoxina diftérica
  • Penicilina
  • Toxoide diftérico (vacuna hexavalente)
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8
Q

Colonización principal

A
  • Piel
  • Vías respiratorias altas - Aparato digestivo
  • Tracto urogenital
  • Se transmiten por gotas
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9
Q

Reservorio

A

Humano

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10
Q

Extra

A
  • Portadores son asiontomáticos

- Enfermedad muy contagiosa y no genera inmunidad

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