Corticosteroids

Question 1

What are the actions of glucocorticoids in terms of acute and chronic inflammatory response?

Answer 1

Glucocorticoids inhibit both acute and chronic inflammatory response by decreasing production of pro-inflammatory chemical mediators (anti-inflammatory actions) and reducing some populations of circulating immune cells (immunomodulatory actions)

Question 2

Glucocorticoids inhibits which expression?

Answer 2

COX expression, thus preventing production of thromboxane A2 and PGI2

Question 3

What is done if there is an increased ESR?

Answer 3

Give high dose steroids immediately.