Corticosteroid and NSAIDs

Question 1

How does dexamethasone reduce inflammation?

Answer 1

Increases syntheiss of lpocortin which inhibits phopholipase A1 and reduced release of arachidonic acid (required for prostaglandin and leukotriene pathways)

Inhibit induction of nitric oxide gene expression by endotoxin and cytokines

Inhibit transcription of cytokines blocking action

Question 2

What are risk factors for steroid induced raised IOP steroid response

Answer 2

POAG
Pigementary glaucoma
FHx glaucoma
FHx steroid response
High myope
DM

Question 3

What are some anti inflammatory effects of steroids?

Answer 3

Reducing the lymphoid contents within the lymph nodes and spleen
Decreasing certain prostaglandins production such as leukotriene
Reudcing macrophage mediated lysosomal contents
Impairing function of macrophages
Increasing catabolism of immunoglobulins