Coronary Disease Flashcards
Management of Suspected NSTE-ACS
Approach to patients with suspected angina and coronary disease
Diagnsostic tests in patients suspected of CAD
- Non-invasive functional imaging for myocardial ischaemia or CTCA is recommended as an initial imaging test in patients in whom obstructive CAD can not be excluded based on clinical assessment alone
- Choose functional vs CT based on clinical likelihood of CAD (higher likelihood functional, lower likelihood CTCA), characteristics that influence test performance and local expertise and availability
- Funcitonal imaging recommended when CT shows CAD of uncertain significance or is non-diagnostic
- Invasive coronary angiography is recommended as an alternative if:
1. High clinical likelihood of CAD
2. Severe symptoms refractory to medical therapy
3. Typical angina on low level of exercise
4. Clinical evaluation indicates high event risk
Invasive functional testing must be available and used to evaluate a stenosis unless very high grade (≥90%)
- Consider invasive angiogram if uncertain diagnosis on non-invasive testing
- Consider CTCA if other non-invasive test is non-diagnostic
- Coronary calcium scoring not recommended to identify patients with obstructive CAD
- Avoid CTCA when extensive coronary calcification, irregular heart rhythm, significant obestiy, inability to follow breath hold commands
Exercise Testing in Suspected CAD
ETT recommended for assessment of:
* Exercise tolerance
* Symptoms
* BP response to exercise
* Arrhythmias
* Event risk in selected patients
Consider ETT when other non-invasive modalities not available
Consider ETT to assess control of symptoms and ischaemia
Avoid if 0.1ms ST depression on resting ECG or digoxin treatment
Factors which reduce pre-test probability of CAD
- No coronary calcium on CT
- Normal exercise ECG
Factors which increase pre-test probability of CAD
- CV risk factors: diabetes, hyperlipidaemia, smoking, HTN, FHx
- Resting ECG changes: Q waves, TWI, ST depression
- LV dysfunction suggestive of CAD
- Abnormal exercise ECG
- Coronary calcium on CT
Diagnostic Pathways in Symptomatic Patients Suspected of CAD
Definition of High Event Risk in Suspected CAD
According to Different Imaging Modalities
- ETT - ≥3% cardiovascular mortality by Duke treadmill score
- PET - ≥10% LV myocardium ischaemic
- Stress echocardiography ≥3 segments with stress induced hypkinesia or akinesia
- Stress MRI ≥2 segments with a stress perfusion defect or ≥3 dysfunctional segments at dobutamine stress
- Coronary CT or IC: 3 vessel disease with proximal stenoses, left main disease or proximal LAD
Definition of High and Low Risk
High Risk Defined as >3% annual cardiovascular mortality risk
Lowe Risk Defined as <1% annual cardiovascular mortality risk
Recommendations
* Stratify risk based on initial imaging modality used to diagnose CAD
* Resting echo recommended in all patients with suspected CAD
* Risk stratifiction, preferably using functional imaging or CTCA, or ETT when others not available and the patient can exercise, is recommended in patients with suspected or newly diagnosed CAD
* In symptomatic patients with high risk profile, invasive coronary angiogram with FFR is recommended, particularly if symptoms refractory to medical treatment or revascularisation indicated for prognosis
* FFR/iFR recommended in patients with no or mild symptoms with high event risk to guide revascularisation for prognosis
* FFR can be used for risk stratification in patients with inconclusive stress imaging
* If CTCA used for risk stratification, if no/few symptoms, do stress imaging before referral for angiogram
* GLS adds incremental information compared with LVEF and shiould be considered when LVEF ≥35%
* IVUS should be considered in intermediate LMS stenosis
Anti-ischaemic drug therapy in CCS
If low HR and low BP, consider Ranolazine or Trimetazadine first line
Avoid nitrates in HOCM and with with phosphodiesterase inhibitors
Antithrombotic therapy recommendations: CCS and Sinus Rhythm
- Aspirin 75mg recommended if previous MI or revascularisation (1a)
- Clopidogrel is an alternative to aspirin if intolerant
- Clopidogrel should be considered in preference to aspirin if PAD or previous TIA/stroke
- Consider aspirin in patients without history of MI or revascularisation but definite imaging evidence of CAD
- Consider adding second antiplatelet drug for long term secondary prevention in patients at high (IIa) or moderate (IIb) event risk of ischaemic events and without high bleeding risk
Antithrombotic therapy - CCS and sinus rhythm, Post PCI
- Aspirin 75mg recommended
- Clopidogrel 75mg (after appropriate loading - 600mg or 5 days of maintenance) recommended for 6/12 unless shorter duration (1-3/12) needed due to risk of life threatening bleeding
- Consider clopidogrel for 3 months if high risk or 1 month if very high risk of bleeding
- Prasugrel or ticagrelor can be considered in elective PCI if high risk features of procedure (underdeployment of stents, LMS, multivessel stenting) or if single agent needed due to aspirin intolerance
Antiothrombotic therapy in CCS and AF / Anticoagulation Indication
- NOAC preferred to VKA
- Recommended when CHADsVASc ≥2 in men, 3 in women, consider when ≥1 in men, 2 in women
- Aspirin or clopidogrel can be added to NOAC if high risk of ischaemic events and do not have high bleeding risk
POST PCI
* Periprocedural DAPT (aspirin and clopidogrel) recommended for patients undergoing stent implantation
* If eligible for a NOAC, use NOAC in combination with anti-platelets over VKA
* Where high bleeding risk prevails over stent thrombosis risk and using rivaroxaban or dabigatran, reduce dose to be used (15mg OD, 110mg BD respectively)
* After uncomplicated PCI, early cessation of aspirin (1 week) should be considered, remaining on dual therapy with clopidogrel and NOAC if stent thrombosis risk is low or if bleeding risk prevails over thrombosis risk
* Triple therapy ≥1month but <6months should be considered where risk of stent thrombosis outweighs bleeding risk
* If VKA needed with along with aspirin or clopidogrel, INR range should be 2.0-2.5 with time in target 70%
* If moderate or high risk of stent thrombosis, NOAC with ticagrelor or prasugrel can be used as dual therapy
* AVOID ticagrelor or prasugrel as part of triple therapy
Use PPI in patients receiving aspirin, DAPT or triple therapy who are at high risk of GI bleeding
Second anti-thrombotic therapy choices in patients on aspirin who have moderate or high risk of ischaemic events and are not at high bleeding risk
- Clopidogrel 75mg OD - for post MI patients who have tolerated DAPT for 1 year
- Prasugrel 10mg or 5mg if body weight <60kg or age >75 - post PCI for patients who have tolerated DAPT for 1 year
- Rivaroxaban 2.5mg BD - post MI >1 year or multivessel CAD
- Ticagrelor 60mg BD - post MI who have tolerated DAPT for 1 year
Moderate Ischaemic Risk
* Diffuse multivessel CAD —> if this and 1 other RF –> High risk
* Diabetes requiring medication
* Recurrent MI
* PAD
* CKD (eGFR 15-59)
Lipid Management CCS
- High risk of events if estblished CAD
- LDL target <1.4 mmol/L (<55mg/dL)
- Consider target <1.0mmol/L if second vascular event within 1 years on maximum tolerated statin therapy
- Statins recommended in all patients
- If target not reached, add ezetimibe
- If target not reached on statin and ezetimibe, PCSK9 inhibitor recommended
Other Drugs
* ACE inhibitors (or ARBs) are recommended if HTN, heart failure (LVEF ≤40%) or diabetes
* Consider ACE inhibitors (or ARBs) if very high risk of events
* Beta-blockers recommended in HFrEF
* Consider beta-blockers in patients with previous STEMI
Descision Tree for Revascularisation in CCS
Follow up of patients with CCS
- Sould be seen at least twice in first year post revascularisation or ACS
- At least annually thereafter, irrespective of symptoms, with ECG every year
- FBC, renal profile and lipids every 2 years
- Consider echo every 3-5 years - if unexplained LV dysfunction, particularly if regional, coronary imaging
- Consider asymptomatic stress testing every 3-5 years
Asymptomatic
* If asymptomatic but high risk by non-invasvive stratification and revascularisation would be considered for prognosis, consider coronary angiogram with FFR
Symptomatic
* Reassess CAD status if detiorating LV and no clear cause
* Risk stratify patients with new or worsening symptoms, ideally with stress imaging, or alternatively exercise stress ECG. Refer quickly
* Invasive angiogram recommended for patients with severe CAD, particularly if symptoms refractory to medical therapy or high risk profile
ANOCA recommendations
- If angina with unobstructed coronary arteries, consider CFR/IMR guidewire assessment (IIa)
- Acetylcholine testing can be considered to assess microvascular spasm
- Consider non-invasive measurement of CFR with transthoracic doppler, MRI or PET
- If CFR <2.0 or IMR ≥25 - abnormal microcirculatory function
- If abnormal CFR or IMR and normal ACh testing - treatment: Betablockers, ACEi, statins, lifestyle changes, weight loss
Vasospastic Angina
- Suspected if angina at rest, circadian pattern, more at night
- Younger, fewer CV risk factors than obstructive CAD (except smoking)
- Prinzmetal’s angina - specific subset with ST elevation
- ECG during angina if possible. Consider ambulatory ECG
- Invasive angiogram or CTCA recommended to investigate extent of underlying CAD in patients with characteristic chest pain and ECG changes at rest which resolve with nitrates or CCBs
- Consider intracoronary provocation testing in patients with typical symptoms and unobstructed coronary arteries
- Rx: Calcium Channel Blockers or long-acting nitrates.
CCS and HTN
- BP target 120-130 systolic in most patients 130-140 in >65 year old
- HTN and recent MI - BB and RAS blockers
- HTN and angina - BB or CCBs
CCS and DM
- Risk factor control to targets (LDL-c, HbA1c, BP) for patients with CAD and DM
- In asytmptomatic DM + CAD patients, periodic resting ECG for conduction system abnormalities and arrhythmais and silent MI
- ACEi recommended in DM +CAD
- SGLT2i recommneded in DM +CAD
- GLP-1 analogue (semaglutide, liraglutide) is recommended in DM +CAD
- Consider functional imaging or CTCA for risk assessment in asmpytomatic patients with DM + CAD