Cornea

Question 1

Causes of neurotrophic keratopathy

Answer 1

Surgical ablation of trigeminal ganglion (for neuralgia)
Stroke
Tumor along track of trigeminal nerve
Peripheral neuropathy
Ocular herpes simplex and herpes zoster keratitis

Question 2

Stages of neurotrophic keratopathy

Answer 2

I: interpalpebral epithelial irregularity and staining with mild Opacification, oedema and tiny focal defects
II: larger persistent epithelial defect with rolled and thickened edges -> punched-out configuration with underlying stromal oedema
III: stromal melting