Core Drugs Of Asthma Flashcards
what are the main drugs used to treat asthma ?
Salbutamol
Fluticasone
Mometasone
Budesonide
Montelukast
what is the mechanic of action of Salbutamol?
Agonist at the β2 receptor on airway smooth muscle cells. Activation reduces Ca2+ entry and this prevents smooth muscle contraction.
what is the drug target of Salbutamol?
Beta 2 (β2) adrenergic receptor
what are the side effects of Salbutamol?
Palpitations/ agitation
Tachycardia/ Arrythmias
Hypokalaemia (at higher doses)
what are some facts about Salbutamol?
Salbutamol is a short acting beta agonist (SABA). It’s half life is 2.5-5hours.
Beta 2 selectivity is not absolute – as a result, cardiac (beta 1) effects can be seen.
Hypokalaemia can be caused via an effect on sodium/ potassium ATPase. This effect can be exacerbated by coadministration with corticosteroids
In 2020, salbutamol was the 12th most commonly prescribed drug in the West London area
what is the mechanic of action of Fluticasone?
Very powerful drugs. Multiple actions on many different cell types. Fluticasone directly decreases inflammatory cells such as eosinophils, monocytes, mast cells, macrophages, and dendritic cells. It reduces the number of these cells and also the number of cytokines they produce.
what is the drug target of Fluticasone?
Glucocorticoid receptor
what are the side effects of Fluticasone?
Local side effects:
Sore throat, hoarse voice, opportunistic oral infections
Systemic side effects:
Growth retardation in children
Hyperglycaemia
Decreased bone mineral density
Immunosuppression
Effects on mood
(Many others)
what are some facts about Fluticasone?
Greater affinity for the glucocorticoid receptor compared to cortisol.
Oral bioavailability <1%. Therefore, any systemic delivery via the inhaled route is predominantly through the pulmonary vasculature.
In 2020, fluticasone was the 72nd most commonly prescribed drug in the West London area
what is the mechanic of action of Mometasone?
Very powerful drugs. Multiple actions on many different cell types. Mometasone directly decreases inflammatory cells such as eosinophils, monocytes, mast cells, macrophages, and dendritic cells. It reduces the number of these cells and also the number of cytokines they produce.
what is the drug target of Mometasone?
Glucocorticoid receptor
what are the side effects of Mometasone?
Local side effects:
Sore throat, hoarse voice, opportunistic oral infections
Systemic side effects:
Growth retardation in children
Hyperglycaemia
Decreased bone mineral density
Immunosuppression
Effects on mood
(Many others)
what are some facts about Mometasone?
Greater affinity for the glucocorticoid receptor compared to cortisol.
Oral bioavailability <1%. Therefore, any systemic delivery via the inhaled route is predominantly through the pulmonary vasculature.
In 2020, mometasone was the 62nd most commonly prescribed drug in the West London area
what is the mechanic of action of Budesonide?
Very powerful drugs. Multiple actions on many different cell types. Budesonide directly decreases inflammatory cells such as eosinophils, monocytes, mast cells, macrophages, and dendritic cells. It reduces the number of these cells and also the number of cytokines they produce
what is the drug target of Budesonide?
Glucocorticoid receptor
