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Drugs > Copy of Toxicities and Side Effects - Sheet1 > Flashcards

Copy of Toxicities and Side Effects - Sheet1 Flashcards

1
Q

Tox: Acetaminophen

A

Rx: N-acetylcysteine (replenishes glutathione)

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2
Q

Tox: Salicylates

A

Rx: NaHCO3 (alkalinize urine), dialysis

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3
Q

Tox: Amphetamines (basic)

A

Rx: NH4Cl (acidify urine)

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4
Q

Tox: AchE inhibitors, organophosphates

A

Rx: Atropine, Pralidoxime

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5
Q

Tox: Antimuscarinic, anticholinergic agents

A

Rx: Physostigmine salicylate, control hyperthermia

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6
Q

Tox: B-blockers

-Bradycardia, Hypotension, CV collapse

A

Rx: Glucagon (incr cAMP in cardiac myocytes)

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7
Q

Tox: Digitalis

A

Rx: Normalize K+, Lidocaine, Anti-dig Fab fragments, Mg2+

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8
Q

Tox: Iron

A

Rx: Deferoxamine, deferasirox

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9
Q

Tox: Lead

A

Rx: CaEDTA, dimercaprol, succimer, penicillamine

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10
Q

tox: Mercury, arsenic, gold

A

Rx: Dimercaprol (BAL), succimer

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11
Q

Tox: Copper, arsenic, gold

A

Rx: Penicillamine

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12
Q

Tox: Cyanide

A

Rx: Nitrite + thiosulfate, hydroxocobalamin

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13
Q

Tox: Methemoglobin

A

Rx: Methylene blue, vit C

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14
Q

Tox: CO

A

Rx: 100% O2, Hyperbaric O2

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15
Q

Tox: Methanol, ethylene glycol (antifreeze)

A

Rx: Fomepizole> ethanol, dialysis

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16
Q

Tox: Opiods

-Severe sedation, respiratory depression, miosis

A

Rx: Naloxone/naltrexone

mu antagonists

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17
Q

Tox: Benzodiazepines

A

Rx: Flumazenil

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18
Q

Tox: TCAs

A

Rx: NaHCO3 (plasma alkalinization)

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19
Q

Tox: Heparin

A

Rx: Protamine

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20
Q

Tox: Warfarin

A

Rx: Vit K, FFP

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21
Q

Tox: tPA, Streptokinase, Urokinase

A

Rx: Aminocaproic acid

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22
Q

Tox: Theophylline

A

Rx: B-blocker for the induced cardiac arrhythmia

-give Benzodiazepine and barbiturates for induced Seizures.

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23
Q

Rxn: Coronary vasospasm

A

Rx: Cocaine, sumatriptan, ergot alkaloids

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24
Q

Rxn: Cutaneous flushing

A

Rx: Vancomycin, Adenosine, Niacine, Ca2+ channel blockers, Caspofungin (by histamine release)

VANCC

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25
Q

Rxn: Dilated cardiomyopathy

A

Rx: Doxorubicin (Adriamycin), daunorubicin

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26
Q

Rxn: Torsades de pointes

A 
Rx: Class III (Sotalol) and class IA (quinidine) anti-arrhyth
*not Amiodarone
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27
Q

Rxn: Agranulocytosis

A

Rx: Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone

Agranulocytosis Could Certainly Cause Pretty Major Damage

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28
Q

Rxn: Aplastic anemia

A

Rx: Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

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29
Q

Rxn: Direct Coombs + hemolytic anemia

A

Rx: Methyldopa, PCN

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30
Q

Rxn: Gray baby syndrome

A

Rx: Chloramphenicol

31
Q

Rxn: Hemolysis in G6PD-defic pts

A

Rx: Isoniazid (INH), Sulfonamides, Primaquine, ASA, Ibuprof, Nitrofurantoin, Dapsone

Hemolysis IS PAINeD

32
Q

Rxn: Megaloblastic anemias

A

Rx: Phenytoin, Methotrexate, Sulfa drgs

Have a blast w PMS

33
Q

Rxn: Thrombotic complications

A

Rx: OCPs (estrogens)

34
Q

Rxn: Cough

A

Rx: ACE-i

35
Q

Rxn: Pulm fibrosis

A

Rx: Bleomycin, Amiodarone, Busulfan

It’s hard to BLAB when you have pulm fibrosis

36
Q

Rxn: Acute cholestatic hepatitis, jaundice

A

Rx: Erythromycin

37
Q

Rxn: Focal-massive hepatic necrosis

A

Rx: Halothane, Amanita phalloides, Valproic acid, Acetaminophen

38
Q

Rxn: Hepatitis

A

Rx: INH

39
Q

Rxn: Pseudomembranous colitis

A

Rx: Clindamycin, ampicillin

40
Q

Rxn: Adrenocortical insuffic

A

Rx: Glucocorticoid w/drawal (HPA suppression)

41
Q

Rxn: Gynecomastia

A

Rx: Spironolactone, Digitalis, Cimeditine, chronic alcohol use, estrogens, Ketoconazole

Some Drugs Create Awkward Knockers

42
Q

Rxn: Hot flashes

A

Rx: Tamoxifen, Clomiphene

43
Q

Rxn: Hyperglycemia

A

Rx: Niacin, tacrolimus, protease-i, HCTZ, corticosteroids, cyclosporine

44
Q

Rxn: Hypothyroidism

A

Rx: Lithium, Amiodarone, Sulfonamides

Your LASt T

45
Q

Rxn: Fat redistribution

A

Rx: Glucocorticoids, protease-i

46
Q

Rxn: Gingival hyperplasia

A

Rx: Phenytoin, Verapamil, Cyclosporine

47
Q

Rxn: Gout

A

Rx: Furosemide, Thiazides, NIacin, Cyclosporine

48
Q

Rxn: Myopathies

A

Rx: Fibrates, Niacin, Colchicine, Hydroxychloroquine, Interferon-a, Penicillamine, Statins, Glucocorticoids. Plus Daptomycin**

FishedD N CHIPS Give you myopathies

49
Q

Rxn: Osteoporosis

A

Rx: Corticosteroids, heparin, chronic use of Omeprazole

50
Q

Rxn: Photosensitivity

A

Rx: Sulfonamides, Amiodarone, Tetracycline

SAT for a photo

51
Q

Rxn: Rash (SJS)

A

Rx: PCN, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital

Bad rash after a PEC SLAPP

52
Q

Rxn: SLE-like syndrome

A

Rx: Hydralazine, INH, Procainamide, Phenytoin
-these drugs are acetylated in the liver! it’s been found that many ppl w Lupus are Slow Acetylators.

Not HIPP to have lupus

53
Q

Rxn: Teeth changes (kds)

A

Rx: Tetracyclines

54
Q

Rxn: Tendonitis, tendon rupture, cartilage dmge

A

Rx: Fluoroquinolones

55
Q

Rxn: Nephrogenic DI

A

Rx: Lithium, demeclocycline

56
Q

Rxn: Fanconi’s

A

Rx: Expired tetraycline

57
Q

Rxn: Hemorrhagic cystitis

A

Rx: Cyclophosphamide, Ifosfamide (prevent by coadministering with mesna)

58
Q

Rxn: Interstitial nephritis

A

Rx: Methicillin, NSAIDs, furosemide

59
Q

Rxn: SIADH

A

Rx: Carbamazepine, cyclophosphamide

60
Q

Rxn: Cichoism

A

Rx: Quinidine, Quinine

61
Q

Rxn: Parkinson-like syndrome

A

Rx: Antipsychotics, Reserpine (inhibits dopamine –> NE), Metoclopramide

62
Q

Rxn: Seizures

A

Rx: Isoniazid (if given without pyridoxine), Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide

With seizures, I BITE My tongue

63
Q

Rxn: Tardive dyskinesia

A

Rx: Antipsychotics

64
Q

Rxn: Antimuscarinic

A

Rx: Atropine, TCAs, H1-blockers, Antipsychotics (low potency -Thi Chlor)

65
Q

Rxn: Disulfiram-like rxn

A

Rx: Metronidazole, certain Cephalosporins, Procarbazine, 1st-gen Sulfonylureas

66
Q

Rxn: Nephrotoxicity/Ototoxicity

A

Rx: Aminoglycosides, Vancomycin, Loop diuretics, Cisplatin

67
Q

Rxn: Serotonin Syndrome

A

Rx: Cryoheptadine (5-HT1/2 receptor antagonist, Antihistamine)

68
Q

P-450 Inducers

A 
Modafinil
Barbiturates
St. John's wort
Phenytoin
Rifampin
Griseofulvin
Carbamazepine
Chronic alcohol use
69
Q

P-450 Inhibitors

A 
Macrolides
Amiodarone
Grapefruit juice
Isoniazid
Cimetidine
Ritonavir
Acute alcohol abuse
Ciprofloxacin
Ketoconazole
Sulfonamides
Gemfibrozil
Quinidine
70
Q

Sulfa drugs

A

Probenicid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide Ab’s, Sulfasalazine, Sulfonylureas
-Rxns: fever, UTI, pruritic rash, SJS, hemolytic anemia, thrombocytopenia, agranulocytosis, and urticaria (hives)

71
Q

Tox: Adenosine

A

-Antidote: Theophylline and caffeine

72
Q

Tox: Serotonin (Serotonin Syndrome)

–> clonus/hyperreflexia, CV collapse (tachy), flushing, hyperthermia, diarrhea, seizures, confusion, agitation

A

-antidote: Cyrohepatidine (5HT1/2 antagonist)

73
Q

1st dose hypotension

A
  • ACE-is (make sure pt not on a diuretic –> hypovolemia –> exacerbates the medications’ effects)
  • A1 antagonists (e.g. Prazosin, Tamsulosin)

Drugs (20 decks)

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