Copper and Digestive Flashcards
1
Q
Environmental cosinderations for type of bacteria (2)
A
food & oxygen (skin/respiratory little food, intestine lots of food)
- anaerobic (in intestine)
- aerobic (in moth/ skin)
- microaerophilic: can tolerate a little O2
2
Q
major bacteria of stomach
A
H Pylori
3
Q
major bacteria of small intestine
A
lactobacilli, bifidobacteria, other probiotics
4
Q
major bacteria of colon
A
greatest variety
5
Q
How to identify bacteria
A
- can be identified at many levels (phylum, genus, species)
- need to find something all bacteria share (such as need to make proteins or RNA)
- look for ribosomes (rRNA)
- DNA sequence must be similar but not exactly same for all bacteria
6
Q
What is fiber?
A
undigestable foodstuffs (complex carbs)
7
Q
Obesity and Bacteria
A
obese mice typically have more firmicutes and less bacteroidetes in colon
8
Q
Cuprous
A
+1
9
Q
Cupric
A
+2
10
Q
how does body transport copper?
A
usually bound to chaperone (metallothionein)
11
Q
How is copper absorbed?
A
ATPase7A is first step b/c needs energy
12
Q
ATPase 7B
A
made in kidney and liver
- mutation of Wilson’s disease
- copper transport protein
13
Q
Wilson’s Disease
A
too much copper
- more common
- oxidative damage to liver and kidney
- accumulate bile in blood
- Kaiser-Fleischer rings in eyes, and jaundice
14
Q
Menkes’ Disease
A
too little copper
- group of disease of occipital horn
- kinky hair ( and no crosslink of collagen (lysyl oxidase)
- x linked
15
Q
Caucasian mutation for ATPase7b
A
H1069Q
