COPD Flashcards

1
Q

How do you calculate pack years?

A

No. of pack years = ( no. of cig. smoked per day x no. of years smoked ) / 20

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2
Q

Aetiology of COPD

A
Smoking 
Age 
Gender
Occupation 
Genetic Factors 
Air Pollution 
Socio-economic Status
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3
Q

What is the pathophysiology (conditions typically observed) of COPD?

A
Chronic bronchitis (inflammation and excess mucus)
Emphysema - alveolar membranes break down and equals dead air space
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4
Q

Describe the flowchart of pathophysiology that starts with noxious particles or gases and give an example of this cause

A

Inflammation

  • gas exchange abnormalities
  • mucus hypersecretion
  • airflow limitation and air trapping
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5
Q

What age of a smoker indicates potential COPD?

A

> 35 years old

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6
Q

What other clinical observations can be used for diagnosis?

A

Spirometry

X Ray

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7
Q

Symptoms of COPD

A
Breathlessness when exerting themselves 
Chronic cough 
Regular sputum production 
Frequent winter chest infections 
Wheeze
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8
Q

Signs of COPD

A
Older patients (>35 years) 
Hyperinflated chest 
Wheeze or quiet breath sounds 
Pursed lip breathing 
Peripheral oedema 
Cyanosis 
Clubbing of nails 
Nicotine staining on fingers and nails 
Underweight 
Use of accessory muscles
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9
Q

What are Pink Puffers? Describe and name cause

A

Emphysema - skinny drawn

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10
Q

What are Blue Bloaters? What is the cause and describe

A

Chronic bronchitis

Not underweight - fat reseveres

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11
Q

How is COPD a systemic disease?

A

Muscle weakness
Depression
Pulmonary hypertension
Osteoporosis

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12
Q

What spirometry results would we expect for a patient with COPD ?

A

FEV1 : FVC ratio of

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13
Q

What can reduce the rate of decline in FEV ?

A

Smoking cessation ( NRT / cold turkey / New Leaf )

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14
Q

What are the aims of COPD treatment?

A
  • prevent and control symptoms
  • reduce frequency and severity of exacerbations
  • improve quality of life
  • improve tolerance to exercise
  • prevent disease progressions
  • minimal side effects
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15
Q

What things should be considered before stepping up a patients therapy

A

Review ; patients inhaler technique / adherence / smoking status / attendance at pulmonary rehab / signs of anxiety or depression

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16
Q

Name examples of SABA (short acting beta 2 adrenoceptor agonists)

A

Salbutamol, terbutaline

17
Q

Name examples of LABA (long acting beta 2 adrenoceptor agonists)

A

Salmeterol, formoterol, indacaterol

18
Q

Name an example of SAMA (short acting muscarinic antagonists)

A

Ipratropium

19
Q

Name examples of LAMA (long acting muscarinic activity)

A

Tiotropium, aclidinium, glycopyrronium

20
Q

How do inhaled corticosteroids treat COPD?

A

Do not modify long term lung functions decline

Reduce eosinophilic inflammation

21
Q

What side effects can arise due to inhaled corticosteroids

A

Pneumonia
Adrenal suppression
Diabetes
Osteoporosis

22
Q

What is the aim of long term oxygen therapy (LOT) and how does a patient qualify for it?

A

Prolongs survival

PaO2

23
Q

What vaccines would be recommended for COPD patients?

A

Pneumococcal

Influenza

24
Q

What is pulmonary rehabilitation

A

Structured exercise therapy

25
Q

What are mucolytics ? Give an example

A

Clearance of mucus from the airways tree

E.g. Carbocisteine

26
Q

What signs show an exacerbation of COPD?

A

Increase in eosinophils
Worsening breathlessness
Cough
Increased sputum production
Change in sputum colour (yellow / green suggests infection)
Worsening peripheral oedema (swelling in lower limbs)

27
Q

How can we manage COPD exacerbations?

A

1 bronchodilators - increase frequency
2 oral corticosteroids - prednisolone 30 mg / day for 7 to 14 days
3 antibiotics if an infective exacerbation - amino penicillin, macrolide or tetracycline
4 oxygen

28
Q

What is COPD?

A

Chronic Obstructive Pulmonary Disease

  • progressive airflow obstruction
  • neutrophilic inflammation
  • irreversible disease
  • no cure
  • predominantly caused by smoking