COPD Flashcards
Chronic Obstructive Pulmonary Disease (COPD)?
refers to a group of diseases that cause airflow blockage and breathing-related problems. It includes emphysema and chronic bronchitis.
Emphysema
destruction of the alveoli
Chronic bronchitis
presence of chronic productive cough for 3 months in 2 successive years
Do people w COPD only show emphysema or chronic bronchitis?
People with COPD often display characteristics of both chronic bronchitis and emphysema.
How common is COPD in Canada?
prevalence of COPD among the population aged 35 years and older was 9.4% (2 million Canadians).
What causes COPD ?
- exposure to irritants that damage your lungs and airways
- Tobacco smoking
Pathophysiology of COPD
Noxious particles and Gases causes:
inflammation of central airways/ peripheral airway remodelling/ parenchymal destruction/ pulmonary vascular changes
Causes:
COPD- mucus hypersecretion/ cilia dysfunction/ airflow limitation/ hyperinflation of lungs/ alveolar destruction/ loss of elastic recoil/ gas exchange abnormalities/ pulmonary hypertension/ cor pulmonale/ systemic effects
Bullae
cystic space >1cm in diameter
Bleb
cystic space <1cm in diameter
Why do people w COPD have pulmonary hypertension?
hypoxia leads to pulmonary vasoconstriction leading to an increase in pressure, therefore leading to pulmonary hypertension
What systemic (extrapulmonary) changes can result from COPD?
unintentional weight loss, skeletal muscle dysfunction, an increased risk of cardiovascular disease, osteoporosis, and depression, among others.
What are the clinical manifestations (signs and symptoms) of COPD?
- dyspnea
- intermittent cough in the morning
- productive cough during winter
- Barrel Chest
What position to patients sit in to relieve symptoms of COPD?
Leaning forward
Why might polycythemia develop later in the development of COPD?
Polycythemia develops as a result of increased production of red blood cells secondary to the body’s attempt to compensate for chronic hypoxemia.
Usual COPD age at onset
> 40 yrs
Usual Asthma age at onset
<40 yrs
Smoking history, COPD vs Asthma
COPD: usually >10 packs/ year
Asthma: Not casual but could become trigger
Which produces sputum, Asthma or COPD?
COPD frequently
Asthma infrequently
Do asthma spirometer findings improve or normalize? What about COPD?
Asthma: Findings often normalize
COPD: Findings sometimes improve but never normalize
Is asthma progressive?
Usually stable with exerbations
is COPD progressive?
Progressive worsening with exacerbations
How are PFT’s conducted?
conducted to measure lung volumes and airflow. -
In PFTs, a spirometer is used. The patient’s age, sex, height, and weight are entered into the PFT computer to calculate predicted values.
The patient inserts a mouthpiece, takes as deep a breath as possible, and exhales as hard, fast, and long as possible.
The computer determines the actual value achieved, predicted (normal) value, and percentage of the predicted value for each test.
Normal PFT
A normal actual value is 80 to 120% of the predicted value
Forced vital capacity (FVC)?
Amount of air that can be quickly and forcefully exhaled after maximum inspiration. Normal: >80% of predicted
Forced expiratory volume in the first second of expiration (FEV1)?
Amount of air exhaled in first second of FVC; valuable clue to severity of airway obstruction. Normal: >80% of predicted
FEV1/FVC?
Ratio of value for FEV1 to value for FVC; useful in differentiating obstructive and restrictive pulmonary dysfunction. Normal: <80% of predicted
Peak expiratory flow rate (PEFR)?
Maximum airflow rate during forced expiration; aids in monitoring bronchoconstriction in asthma. Normal: <600L/min
What is cor pulmonale, and how can it result from COPD?
Cor pulmonale is hypertrophy of the right side of the heart, with or without heart failure, that results from pulmonary hypertension. In COPD, pulmonary hypertension is caused primarily by constriction of the pulmonary vessels in response to alveolar hypoxia
What does acidosis following hypoxia in the pulmonary vessels cause?
Further vasoconstriction leading to Cor Pulmonale
How are acute exacerbations of COPD (AECOPD) defined?
An acute exacerbation of COPD (AECOPD) is defined as a sustained worsening of COPD symptoms. The term sustained implies a change from baseline that lasts 48 hours or longer
The frequency of AECOPD is related to what?
related to the underlying severity of airflow obstruction, and patients with a history of frequent exacerbations are more likely to continue experiencing frequent exacerbations.
Why is it important to identify whether a client has a purulent or non-purulent exacerbation of COPD?
Exacerbations should be characterized as purulent or non-purulent to assist in determining the need for antibiotic therapy; purulent exacerbations necessitate antibiotic therapy.
What causes AECOPD?
The cause of AECOPD is often difficult to determine. Noninfectious triggers for exacerbations include exposure to allergens, irritants, cold air, and air pollution.
What vaccinations should be recommended for people with COPD?
Annual influenza vaccination and pneumococcal vaccination
How can COPD lead to acute respiratory failure?
Frequently, patients with COPD wait too long to contact their health care provider when they develop fever, increased cough and dyspnea, or other symptoms suggestive of AECOPD.
An exacerbation of cor pulmonale may lead to acute respiratory failure.
Discontinuing bronchodilator or corticosteroid medication may also precipitate respiratory failure.