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Question 1

weight loss for women with BMI of > 27 kg/m^2

stop oral hypoglycaemic agents, apart from metformin, and commence insulin

folic acid 5 mg/day from pre-conception to 12 weeks gestation

detailed anomaly scan at 20 weeks including four-chamber view of the heart and outflow tracts

tight glycaemic control reduces complication rates

treat retinopathy as can worsen during pregnancy

Answer 1

randomised, open-label, non-inferiority trial