Control of Food Intake Flashcards
What is the name of the well-known hormone that is synthesised by the gastric fundus during fasting, and involved in the initiation of feeding?
Ghrelin
Mr and Mrs Lovecake went to see their Dr to discuss the problems they are having with binge eating in the last 10-15 years. They have had to make several modifications to their house to allow them to get through their door. Their Dr believed that their satiety signal was set too high and referred them to have this examined. Which hormone is secreted by adipocytes which signals satiety?
Leptin
Cholecystokinin (CCK) has a number of important functions in the body, including secretion of bile from the gallbladder, inhibition of gastric acid secretion, and control of food intake. Which of the following best describes the central and peripheral effects of CCK?
It slows down gastric emptying and inhibits appetite if injected into the hypothalamus
Mr Hungaray has a special relationship with food in that he loves all the wrong types of food. This has resulted in him gaining weight over the last 2 years. His Dr quizzed him on what he thinks are the chief regulators of his appetite. Please help Mr Hungaray identify the least unlikely regulator of appetite from the list below.
Adrenaline
A 54-year-old man was recently involved in a nasty road traffic accident which resulted in a lesion in the ventromedial wall of the paraventricular nucleus of his hypothalamus. Which condition below best describes the effect of such an accident on the man?
He is likely to suffer with hyperphagia which will cause weight gain if he is less active
Some first year undergraduate students went to Sam’s café for lunch. They each had a portion of regular meal and some fries. One of the students was heard asking the rest of the group to name one substance which is being released co-incident with their meal and involved in regulation of feeding. None of the students got it right; please identify the correct one from the list below.
CCK
As a follow on question, another group member asked, “which of the following hormones act reciprocally to control food intake?”
Ghrelin and leptin
Provide a very brief answer to what the consequence will be of the denervation of the stomach and intestine on food intake
Denervation will have little or no effect; peripheral signals from adrenals, pancreas, adipose and GIT will continue to operate to control food intake and energy expenditure
Name the satiety centre
ventromedial wall of the paraventricular hypothalamus
Name the feeding centre
Lateral hypothalamus
What is the effect of lesion to the lateral hypothalamus?
causes aphagia
Name 2 central and 3 peripheral substances that are important for the control of food intake
Central controls: NPY, Growth hormone releasing hormone, somatostatin
Peripheral controls: ghrelin, leptin, insulin, noradrenaline
