Control of arterial pressure 2 Flashcards

1
Q

ecf

A

plasma vol + interstitial fluid volume

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2
Q

what hapens if plasma voluem falls

A

compensatory mechanisms shifts fluid form the intersttiial comprtment to the plasma comprtment

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3
Q

what affects extracellular fluid volume

A

water excess or deficit
na excess or deficit

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4
Q

role of hormones

A

act as effectors to regulate the extracellular fluid volume and plasma by regulating water and salt balance

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5
Q

hormones which regulate ecfv

A

RAAS
NPs
ADH

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6
Q

role of renin

A

released from kidneys and stimulates the formation of angiotensin 1 in the blood from angiotensinogen produced by the liver

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7
Q

what is angiotensinogen produced by

A

liver

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8
Q

where is renin released from

A

kidneys

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9
Q

ACE role

A

converts angiotensin 1 to angiotensin 2

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10
Q

function of angiotensin 2

A

stimulates the release of aldosterone from adrenal cortex
and causes systemic vasoconstriction; incraesees svr

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11
Q

role of aldosterone

A

acts on kidneys to increase sodium and water rentention; increases plasma volume

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12
Q

effect of angiotensin 2

A

increased svr and bp
increased ads and plasma volume
increases thirst

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13
Q

natriuretic peptides

A

peptide hromones synthesised by heart

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14
Q

when are nps released

A

in response to cardiac distension or neurohormonal stimuli

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15
Q

what do nps cause

A

excretion of salt and water in the kidneys therby reducing blood volume and bp
decraeses renin release ; decraese bp
act as vasodilatoirs
counter reg system for raas

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16
Q

NPs released

A

anp and bnp

17
Q

anp

A

28 amino acid peptide synthesised and stored by atrial muscle cells

18
Q

when is anp released

A

in response to atrial distension; hypervolemic states

19
Q

bnp

A

32 amino acid peptide synthesised by heart ventricles

20
Q

ADH

A

peptide hormone derived from a prehormone precursor synthesised by hypothalamus and stored in posterior pituitary

21
Q

what is secretion of adh stimulated by

A

reduced extracellular fluid volume and increased extracellular fluid osmolality

22
Q

what is plasma osmolality monitored by

A

osmoreceptors in brain

23
Q

what is adh release stimulated by

A

increased plasma osmolality

24
Q

where does adh act

A

in the kidney tubules to increase the reabsorption of water; increases ecfv, plasma and co

25
Q

where else does adh act

A

in blood vessels to cause vasoconstriction

26
Q

where are baroreceptors located

A

arch of aorta/ carotid sinus

27
Q

is angiotensin a vasodilator or constrictor

A

potent vasodilator

28
Q

where is adh synthesised

A

hypothalamus

29
Q
A