Contraction Of Heart Flashcards
AP precedes contraction by
20 msec
Mention the sources of calcium for cardiac muscle contraction
- Ca entry from ECF
2. Ca triggered Ca release by SR
DHP receptor is ….
While ryanodine receptor is …..
Voltage gated Ca-channels
Ligand-gated Ca-channels
Mention the complex respnosible for inhibting actin-myosin interaction
Troponin-tropomyosin complex
Mention the Ca binding component if myofibril
Troponin C
…… moves during contraction to uncover actin binding site for myosin.
Tropomyosin
Actin-myosin binding is broken in presence of …..
ATP
Mention methods of Ca removal during relaxation
Pumping Ca into longitudinal portion of SR Ca pump (active medahnism) to ECF Na-Ca exchanger (passive mechanism)
The mostvimportant ohysiological factor that enhances relaxation is …..
Sympathetic stimulation
Mention the mechanism by which sympathetic stimulation inc heart rate & its important
By accelerating the rate of relaxation by increasing the activity of SR Ca ATPase pump leading to faster & more Ca re-uptake by SR.
This is important because the increased rate of relaxation compensates for the decreased time of ventricular filling during the shortened diastole
Mention the most important pathological factor affecting rate of relaxation & its mechansim
Ischemic heart disease
The activity of SR Ca-ATPase pump & hence the Ca-reuptake by SR are decreased resulting in a depressed rate of relaxation (diastolic dysfunction)
Contraction reaches its peak during ….
The last 1/3 of thecplateau of AP
Mention the importance if long ARP in cardiac muscle
Almostv50% of ventricular relaxation is obligatory before it can respond to a second stimulus & this guarantees satisfactiry filling.
Eachof atrial & ventricular muscle sheets act as ….
One big muscle unit because it is a functional syncytium (all or none rule)
Mention intrinsic & extrinsic factors affecting force of myocardial contraction
I: preload, afterload, frequency if stimulation & contractility
E:nervous, drugs, ECF ions, neurohormonal.
Define contractility (now)
The intrinsin ability of the cardiac muscle to generate firce at constant length
The term prload refers to …..
Its effect is describe by … law
The degree of passive stretch exerted by volume of blood in the ventricle just before its contraction
Frank-Starling
The ……. determines maximum tension , while the …… determine passive tension
Length of CE
Length of PE
Mention the effect of stretch of muscle within limits
Elongates the CE and this exposes more actin binding sites for myosin heads thus increasing the number of cross-bridges when muscle is stimulated.
Mention the effect of overstretch of muscle
Deterioration of active tension due tobpulling away of actin filaments from the myosin heads.
In human, Lmax is ….
2.2 microns
The afterload is increased when ……..
Beating against higher arterial BP, or a stenosed valve
The stages of cardiac muscle contraction are ….&….
Isometric & isotonic
Describe isometric contraction
Shortenig of CE is compensated by lengthening of PE, no lifting of load, force is generated in the form of increased tension alone.