Contraceptive Technique Flashcards
Emergency Contraception:
- Levonorgestrel
- -aka
- -dosing
- -effective within how many hours after intercourse?
- -SE
- -CI
- -MOA
LEVONORGESTREL:
Aka: plan B
Dosing:
-levonorgestrel 0.75mg two pills taken 12hrs apart
-Plan B One Step or Next Choice One Dose is single levonorgestrel 150mg pill
Effective up to 120hrs after the event but best to take as soon as possible.
SE:
- N/V
- irregular bleeding the month after tx
- less common: dizziness, fatigue, HA, breast tenderness
CI: NONE! : )
MOA:
- progestin only
- only works before ovulation has occurred, it does not interrupt a pregnancy and has no known adverse SE on pregnancy or fetus.
- delays ovulation.
Emergency Contraception: Copper IUD
- MOA
- CI
MOA:
- interfering with fertilization or tubal transport
- preventing implantation by altering endometrial receptivity. (inhospitable environment)
CI: if pregnant
What are the categories of contraception?
Hormonal
IUD
Barrier
Permanent
Oral Contraceptives:
- MOA
- whats the difference between the older and newer progestins?
MOA:
- estrogen:
- -suppression of GnRH and inhibits the midcycle surge of LH preventing ovulation. suppresses FSH secretion thereby preventing ovarian folliculogenesis.
- -stabilizes endometrium to minimize breakthrough bleeding.
- progestins:
- -suppress LH secretion and prevent ovulation
- -thickens mucus to prevent sperm migration
- -creates an atrophic endometrium unfavorable to implantation
- -impairs normal tubal motility/peristalsis
Progestins:
-older are more androgenic. (levonorgestrel)
-newer are less androgenic. (Drospirenone/Yasmin/Yaz)
Off label of oral contraceptive pills?
Endometriosis
Acne/hirsutism
Tx of heavy, painful, irregular periods
reduce ovarian cysts
PCOS
PMS/PMDD
Decreases risk of ovarian** and colon CA
Descreass menstrual migraine
What are the oral contraceptive preparation types?
Monophasic
Multiphasic (diff levels of hormones throughout cycle)
Extended cycle
Progestin only pill (POP)
When is the proper time to begin a new oral birth control method?
Quick start: start the day of Rx regardless of the day of cycle once pregnancy is ruled out
Sunday start: start 1st sunday after period begins
Start 1st day of menses
- quick start or sunday start must use back up method for 7 days after starting the pill.
- progesterone pill should be started in first 5 days of menses.
Important education to provide to the patient about oral birth control.
take the med same time everyday.
If miss 1 pill take as soon as realized and continue to take remainder of pills regularily.
If miss 2 pills in a row, “double up” for 2 days.
*must use back up method for rest of cycle
High risk time for conception if next pill cycle not started on time
Notify with increasingly severe or frequent HA, SOB, chest pain or swelling of an extremity
Menses are shorter, lighter, and less cramping.
progestin only pill should be taken in 3hr window
Ortho-Evra
- route of administration & directions
- what hormones are being delievered?
Route of admin: transdermal patch; changed every 7 days for 3wks and then 1wk off for menses.
Hormones:
-estradiol and progestin
NuvaRing
- route of administration & directions
- what hormones are being delivered?
Route: intravaginal; in for 3wks and taken out 1wk for menses.
Hormones: estradiol and progestin
What are the absolute CI for estrogen contraception?
Hx of thromboembolic event, stroke, or thrombogenic mutation (factor V leiden)
Known CVD, cardiomyopathy, BP 160/100 or greater, complicated valvular heart dz
SLE with postive antiphopholipid abys
Women 35 or older who smoke
Migraines with Aura
Women 35 or older with migraines
Hx of cholestatic jaundice with pill use
hepatic carcinoma or benign adenoma, any active liver dz or severe cirrhosis
breast cancer (current)
first 21 days post partum
undiagnosed abnormal uterine bleeding.
Careful consideration before use of estrogen
HTN
Anticonvulsant therapy
Migraines without aura
DM
Hx of bariatric surgery w/ malabsortive procedure like Roux en Y
Psychotic depression
Ulcerative colitis
Obese (greater 35YO)
What is the efficacy of hormonal pills, patch, and ring?
SE of hormonal contraception (E-P)
Theoretical/correct use: less than 1%
Typical use: 9%
SE:
- nausea/bloating
- breast tenderness
- spotting/break though bleeding (*MC SE)
- amenorrhea
- fatigue
- HA
- depression/moodiness
- decreased libido
Risks w/ E-P therapy
CVD: thrombotic not atherosclerotic
HTN: may cause mild elevation
Stroke: ischemic
Mild insulin resistance (progestin)
serum triglycerides and HDL increases; LDL decreases (estrogen)
decrease HDL andd increased LDL (progestin)
Venous thromboembolic dz
cholithiasis
What is a major hormonal contraceptive-drug interaction?
drugs that increase liver microsomal enzyme activity accerlerates OCs metabolism and may decrease efficacy
*Rifampicin (Rifampin) is the only proven antimicrobial shown to decrease efficacy of OCs.