Contraception Flashcards
Combination pills
Alter the dosage of estrogen and progestin throughout the cycle
Ethinyl estradiol + norgestimate (oath-cyclen, Ortho Tri-cyclen, Ortho Tri-cyclen Lo
Ethanol estradiol or menstranol, synthetic estrogens
Norethindrone
Progestin-Only
Mini-pills
Not as effective
MOA affects the cervical mucus and the endometrium
Most likely changes tubal transport of ocyte and sperms
Estrogenic effects of OCP’s
- Ovulation inhibited by suppression of FSH/LH
- Implantation inhibited by alteration of the endometrium
- Ovum transport is accelerated
- Luteolysis may occur as estrogen causes progesterone levels to fall
Progestational effects
- Thick cervical mucus interferes with sperm transport
- Capacitation may be inhibited
- Ovum transport is accelerated
- Implantation is hampered by suppression of endometrium
- Ovulation inhibited by hypo-thalamic-pituitary-ovarian disturbance
Advantages of OCP’s
- Excellent protection against unwanted pregnancy
- Safe for most women
- Decreased menstrual cramps and pain
- Less menstrual blood flow
- Improvement to facial acne
- Women control own fertility
- Excellent reversibility and easy to use
- May provide protection against ovarian and endometrial cancer, ectopic pregnancy, PID, functional ovarian cysts, endometriosis, uterine fibroids
Disadvantages of OCP’s
- May lead to mood changes
- No protection against STD’s, HIV
- Expensive for some women
- Rare circulatory complications which may be dangerous
- increased risk of rare liver tumors
- pills must be taken every day
- possible SE of Nausea, HA’s, breakthrough bleeding
Excessive estrogenic effects
- Dysmenorrhea
- Nausea
- Chloasma
- CVA
- DVT
- Thromboembolic disease
- PE
- Telangiectasis
- Hepatic adenoma/adenocarcinoma
- Cervical changes
- Breast tenderness
Deficiencies in estrogen
- No withdrawal bleeding
- Decreased duration in menstrual bleeding
- Continuous spotting/bleeding
- Breakthrough bleeding on day of cycle 1-9
- Atrophic vaginitis
Excessive progestational effects
- Breast tenderness
- Transient hypertension
- Depression
- Fatigue
- Decreased libido
- Decreased duration of menstrual bleeding
- Increased appetite
Deficiencies in progesterone
- Breakthrough bleeding DOC 10-21
- delayed menses
Excessive androgenic effects
- Hirtuism
- Acne
- Oily skin
- Edema
- Increased libido
Excess estrogen/deficient progesterone combo effects
- Dysmennorrhea
- Menorrhagia (excessing bleeding during menses)
- n/v
- HA
- Irritability
- bloating/edema
- syncope
Absolute contraindications of OCP’s
- H/o thromboembolic disorders
- H/o CVA
- CAD
- Known breast carcinoma
- Pregnancy
- Benign or malignant liver tumor, impaired liver function
- Previous cholelithiasis during pregnancy
- Undiagnosed, AUB
General consideration of OCP’s
Being with low-dose combined or multiphasic pill (35mcg or less)
Progestin only pills may be used for women w/ hx of migraine HA’s, who are breast feeding or who have contraindications to combo pills
Adverse effects of OCP’s
- AUB (may need higher dose)
- Amenorrhea or hypermennorrhea (may need progestin increased)
- Birth defects (estrogen is preg category X)
- Cancer (pts w/ + family hx of breast ca should not use)
- Hypertension
- Weight gain, increased appetite, fatigue, depression, acne, hirtuism (may need to decrease progestin)
- Nausea, edema, breast tenderness (may need to lower estrogen)
- Thromboembolic disorders
- Abx and anticonvulsants can decrease effectiveness of OCP’s
- OCP’s can decrease effectiveness of warfarin, insulin and some hypoglycemics
Nuva RIng
Flexible, prescriptive contraceptive ring
Typical failure rate is <1-2%
MOA of Nuva RIng
Releases synthetic estrogen and progestin for 1 month
Release of hormone through vaginal contact
Prevents ovulation
Advantages of Nuvaring
Convenient, once per month insertion Easily reversible Fewer mood swings Discreet May lead to shorter, lighter and more regular menstrual periods
Disadvantages of Nuvaring
Similar to OCP’s
Diaphragm’s, cervical caps, or shields cannot be used as back up
May worsen depression
Contraindications of Nuvaring
Age >35 yo
Smoking
Uncontrolled hypertension
Hx of any cardioembolic disorder
Management of Nuvaring
Inserted 1x per month for 21 days (not more not less)
Must be inserted on the same day of the week as it was inserted last cycle or pregnancy may occur
If ring slides out–MUST be inserted within 3 hours
Unopened packages must be proceed from sunlight or high temps
The Patch- Ortho Evra
Transdermal contraceptive patch that releases synthetic estrogen and progestin
Failure rate <1-2%