Contraception Flashcards

1
Q

Combined oral contraceptives

A

This form of birth control suppresses ovulation (the monthly release of an egg from the ovaries) by the combined actions of the hormones oestrogen and progestogen.

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2
Q

Progestogen only methods

A

Progestogen-only pill; Progestogen-only implant; Progestogen-only injectables. Progestin-only methods have several effects in the body that help prevent pregnancy: The mucus in the cervix thickens, making it difficult for sperm to enter the uterus and fertilize an egg; they stop ovulation, but they do not do so consistently.

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3
Q

Emergency contraception

A

Forms of contraception, especially contraceptive pills, that are effective if administered within a specified period of time after sexual intercourse.

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4
Q

Intra-uterine devices

A

A contraceptive device fitted inside the uterus and physically preventing the implantation of fertilized ova.

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5
Q

Pearl index

A

The number of contraceptive failures per 100 women-years of exposure, and uses as the denominator the total months or cycles of exposure from the initiation of the product to the end of the study or the discontinuation of the product.

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6
Q

The Perfect Contraceptive

A
  • 100% Reliable
  • 100% Safe
  • Non User Dependent
  • Unrelated to Coitus
  • Visible to the Woman
  • No ongoing Medical Input
  • Completely reversible within 24 hours
  • No Discomfort
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7
Q

Risks

A
Risks of Treatment
• Cardiovascular
• Neoplastic
• Emotional
• Infection related
• Allergic
• Iatrogenic
Risks of no treatment
• Childbirth related
• Abortion related
• Social costs
• Economic costs
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8
Q

Benefits

A
Benefits of Treatment
• Non Contraceptive 
• Psychosexual
• Choice
• Sexual Health
• Cost savings
• Female equality

Benefits of no Treatment
• Non interference
• Population growth
• Control of women

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9
Q

Combined Oral Contraception

A
  • Oestrogen EthinylOestradiol - 20,30,35,50 micrograms
  • Progestogens
  • Older (2nd generation) – Norethisterone (Norethindrone) & Levonorgestrel
  • Newer(3rd generation) – Desogestrel, Gestodene & Norgestimate (Noregestromin)
  • Latest (derived from Spironolactone) - Drospirenone
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10
Q

Combined Oral Contraception explained

A

Oestrogens act
• On anterior pituitary & hypothalamus
• Directly on the ovary
• On the Endometrium

Progestogens act
• On anterior pituitary & hypothalamus
• Directly on the ovary
• On the Endometrium
• On the fallopian tubes
• On cervical mucus

sites of action diagram

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11
Q

Combined Oral Contraception-

Benefits

A
1. Contraceptive
• Reliable
• Safe
• Unrelated to coitus
• Woman in control
• Rapidly reversible
  1. Non contraceptive
    • Halve ca ovary
    • Halve ca endometrium
    • Helps endometriosis, menorrhagia, dysmenorrhoea,
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12
Q

Combined Oral Contraception

Risks

A
  • Cardiovascular - Arterial – Progestogen , HBP, smoking - Venous – Oestrogen-VTE-clotting disorders (DVT, PE, Migraine)
  • Neoplastic- Breast, Cervix, Liver
  • Gastrointestinal– COH/insulin metabolism, Weight gain,Crohns disease
  • Hepatic – hormone metabolisms, congenital nonhaemolytic, jaundices, gall stones
  • Dermatological – Chloasma, acne, erythema multiforme
  • Psychological – Mood swings, depression, Libido
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13
Q

Combined Oral Contraception

Pill Rules

A

Start 1st packet 1st day of a menstrual period
• Take 21 pills and stop for 7 day break (PFI)
• Restart each new packet on 8th day (same)
• Do not start new packets late
• If late or missed pills in 1st 7 days, condoms
• If missed pills in last 7 days no PFI

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14
Q

Combined Oral Contraception

Interacting Medication

A
  1. Liver enzyme inducing drugs - see list/MIMS
    • Affect metabolising of both oestrogen and progestogen
    • Beware rifampicin and anti-epileptics
    • 2. Broad spectrum antibiotics
    • Affect enterohepatic circulation of oestrogen
    only (40%)
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15
Q

Combined vaginal contraceptive

A
Same as COCP except vaginal delivery 
(ring) for 21 days
• Remove for 7 days
• Adv – don’t have to take every day
• Disadv - don’t have to take every day!!
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16
Q

Progestogen Only Methods

A
Default Methods
• Implants:  Nexplanon
Norplant (LNG)
• Hormone releasing IUCD:
Mirena IUS (LNG)
 User Dependent Methods
• POPs
- Desogestrel (Cerelle)
- Norethisterone 
- Ethynodiol diacetate
- Levonorgestrel
- Norgestrel

Injectables

  • Depo Provera (MPA) (12weekly)
  • Noristerat (NET)
17
Q

Why Cerelle is better than older POPs…

A
• As effective as COCP
• No oestrogen – CIs e.g. breastfeeding
• Favourable side effect profile vs older 
POPS
• Bleeding as predictable as COCP
• 12 hour window
18
Q

IUCDs

A

Copper bearing intrauterine contraceptive
devices are inserted into the uterus by
suitably trained practitioners and may be
left in situ long term and act by
• 1. Destroying spermatozoa
• 2. Preventing implantation – Inflammatory
reaction and prostaglandin secretion as well
as a mechanical effect.

19
Q

IUCDs types

A
. Copper bearing Ortho T 380 – 8 -12yr
• Multiload 375 – 5yr
• Multiload 250 – 5yr (Standard 
• & Short)
Nova T 380 – 5yr
• Nova T 200 – 5yr
• GyneFix  (IUI) – 5yr
• 2.  Hormone bearing – Mirena (IUS) – 5yr
20
Q

IUCDs Benefits

A
Non user dependent
• Immediately and retrospectively effective
• Immediately reversible
• Can be used long term
• Extremely reliable
• Unrelated to coitus
• Free from serious medical dangers
21
Q

IUCDs Disadvantages

A
• Has to be fitted by trained medical 
personnel
• Fitting may cause pain or discomfort
• Periods may become heavier & painful
• It does not offer protection against infection
• Threads may be felt by the male
22
Q

IUCDs Risks

A
  • Miscarriage if left in situ if a pregnancy
  • ?ectopics
  • May be expelled
  • The uterus may be perforated
23
Q

IUCDs Absolute contraindications

A
  • Current pelvic inflammatory disease
  • Suspected or known pregnancy
  • Unexplained vaginal bleeding
  • Abnormalities of the uterine cavity
24
Q

IUCDs- Relative contraindications?

A
  • Nulliparity
  • Past history of pelvic inflammatory disease
  • Not in mutually monogamous relationship
  • Menorrhagia / Dysmenorrhoea
  • Small uterine fibroids
  • NO!!!
25
Condoms- Advantages
``` Male • Man in control • Protects against STIs • No serious health risks • Easily available (free at Family Planning clinics) ``` ``` Female • Woman in control • Protects against STIs • Can be put in in advance and left inside after erection lost • Not dependent on male erection to work ```
26
Condoms Disadvantages
``` Male • Last minute use • Needs to be taught • May cause allergies • May cause psycho sexual difficulties • Higher failure rate among some couples • Oily preparations rot rubber ``` ``` Female • Obtrusive • Expensive • Messy • Rustles during sex • Uncertain failure rate ```
27
Caps
``` Diaphragm Caps • Made of latex • Fit across vagina • Sizes 55 – 95mm in 5cm jumps • Must be used with spermicide and left in at least 6 hours after sexual intercourse ``` ``` Suction (cervical) Caps • Made of plastic • Suction to cervix or vaginal vault • Different sizes • Must be used with spermicide and left in 6 hours or more. ```
28
Caps- Advantages
``` Diaphragm Caps • Woman in Control • Can be put in in advance • Offers protection against cervical dysplasias • Perceived as “natural” ``` ``` Suction Caps • Suitable for women with poor pelvic muscles • No problems with rubber allergies • Very unobtrusive • Woman in control ```
29
Caps- Disadvantages
``` Diaphragm Caps • Needs to be taught • Messy • Higher failure rate than most other methods • Higher UTI • Higher Candiasis ``` ``` Suction Caps • Needs an accessible and suitable cervix • Higher failure rate than diaphragm • Not easy to find experienced teacher ```
30
Fertility Awareness
• Prediction of ovulation ? 14/7 before period • Sperm can survive 5 days in female tract • Ova can survive 24 hours • Ova are fertilised in the fallopian tube and take 4 days to reach the uterus and implant • Cervical mucus is receptive to sperm around the time of ovulation • Use Periodic Abstinence/alternative contraception to avoid pregnancy • Time intercourse to pre-ovulatory phase to conceive
31
Natural Family Planning
* Temperature * Rhythm * Cervix position * Cervical mucus * Persona * Lactational amenorrhoea (LAM)
32
Fertility Awareness adva/disadvs
``` Advantages • Non medical • Can be used in 3rd world • Allowed by Catholic church • Can result in closeness of understanding between partners ``` ``` Disadvantages • Failure rate heavily user dependent • Requires skilled teaching • May require cooperation between partners • May involve limiting sexual activity • Can cause strain ```
33
Emergency Contraception
• Postcoital Pills - Up to 72 hours after unprotected sexual intercourse (UPSI) • Schering PC4 – prevents 3 out of 4 pregnancies which would have occurred • Levonelle – prevents 7 out of 8 pregnancies • ellaOne (ulipristal)–similar • Copper bearing IUCDs • Up to 5 days after presumed ovulation or 5 days after one singleepisode of UPSI at any time of the cycle • Failure extremely rare
34
Postcoital pills
Levonelle 2 consists of 2 tablets each containing 750 micrograms of Levonorgestrel • 1.5mg one dose ``` • PC4 • Lower failure rate in 1st 24 hours. • Causes nausea & vomiting in many women • Contraindicated during focal Migraine attack • Levonelle 2 • Lower failure rate in 1st 24 hours • Very little nausea • Only contraindicated in women taking very potent liver enzyme medication (anti TB) ``` ``` ellaOne – ulipristal acetate • New selective progestagen receptor modulator (SPeRM) • Up to 120 hours • RR 0.58 pregnancy vs Levonelle • Possible slightly higher side effect profile – GI symptoms mainly ```
35
Post coital pills - effectiveness
Levonelle 2 Up to 24hrs – 95% 25 – 48 hrs - 85% 49 – 72 hrs- 58% Schering PC4 Up to 24 hrs – 77% 25 – 48 hrs – 36% 49 – 72 hrs – 31%
36
Postcoital Contraception
``` PC4 & Levonelle 2 • Act by postponing ovulation in 1st part of the cycle – So beware! • ??Act by preventing implantation in 2nd part of the cycle • Copper IUCDs • Copper kills sperm in 1st part of the cycle • Device prevents implantation in 2nd part of the cycle ```
37
CONTRACEPTIVE | EFFICACY (perfect use!)
``` COCP - <1 /100 WOMAN YEARS Depo - <1 /100 WOMAN YEARS IUCD - <1 /100 WOMAN YEARS IUS - <1 /100 WOMAN YEARS Implants - <1 /100 WOMAN YEARS POP - 1 /100 WOMAN YEARS Condoms- Male - 2 /100 WOMAN YEARS - Female - 5 /100 WOMAN YEARS NFP - 2 /100 WOMAN YEARS Diaph /Caps - 4-8 / 100WOMAN YEARS Female Sterilisation - 1 / 200 failure rate Male Sterilisation - 1 / 2000 failure rate ```
38
CONTRACEPTIVE | EFFICACY (real use!)
COCP - 8 /100 WOMAN YEARS • POP - 8 /100 WOMAN YEARS • Condoms - 10-15 /100 WOMAN YEARS • If it involves user input error the risks of failure are much higher...