Contraception Flashcards

1
Q

What is the pearl index (PI)?

A

measure of a contraception risk of pregnancy per 100 woman-years of using the given contraception method

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2
Q

How is contraception affected in breast feeding women?

A

• In a women is who fully breastfeeding, amenorrhoeic and less than 6 months postpartum- breastfeeding is
>98% effective at preventing pregnancy
• If a women has unprotected sex <21 days postpartum she will not require emergency contraception
• The COCP affects breastmilk volume and is avoided before 6 weeks postpartum- relatively contraindicated between 6 weeks and 6 months postpartum
• Progesterone-only methods have no effect on milk production
• The IUD can be inserted from 4 weeks postpartum

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3
Q

How does contraception change in later life?

A
  • Women <50yrs should continue contraception for at least 2 years after the last period
  • Women >50yrs should continue contraception for 1 year after the last period
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4
Q

What are the types of hormonal contraception?

A

o Progestogen as a tablet- POP ‘mini-pill’
o Progeston as a depot- Nexplanon, Depo-Provera or in the levonorgestrel-containing IUS
o Combined hormonal contraception (CHC)
 COC- mono/bi/triphasic pill
 Transdermal patch
 Vaginal ring

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5
Q

How do COCP work?

A

• COCs act by exerting –ve feedback on gonadotrophin release and thereby inhibiting ovulation
they also thin the endometrium and thicken cervical mucus
• Most COC preparations contain a synthetic oestrogen (ethinyloestradiol)- newer COCs (Qlaira or Zoely) contain natural oestrogen (oestradiol valerate) which is metabolised to the naturally occurring oestradiol in the body

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6
Q

How are COCP taken?

A

• A single tablet, containing oestrogen and progestogen is taken every day for 3 weeks- then stopped for 1 week
• Vaginal bleeding occurs at the end of the pill packet as a result of hormone withdrawal on the endometrium-the cycle is then restarted
• Pill packets can be take consecutively without a break to reduce the frequency of the withdrawal bleed although increased irregular spotting may occur
Failure rate of 0.2 per 100 woman years

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7
Q

What is the COCP also useful for?

A
o	Menstrual cycle control
o	Menorrhagia
o	Premenstrual symptoms
o	Dysmenorrhoea
o	Acne/hirsutism
o	Recurrent simple ovarian cysts
o	Protection against endometriosis & fibroids
o	Reduced risk of PID
Reduced incidence of ovarian, endometrial and bowel CA
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8
Q

When can reduced absorption of the COCP occur?

A

suffering from diarrhoea, vomiting or taking some oral antibiotics

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9
Q

What are the major complications of the COCP?

A
o	Venous thrombosis
o	Myocardial infarction
o	Cerebrovascular accidents
o	Focal migraine
o	Hypertension
o	Jaundice
o	Liver, cervical and breast carcinoma
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10
Q

What are the side effects of the COCP?

A

o Nausea
o Headache
o Breast tenderness
o Breakthrough bleeding- first few months
o Suppressed lactation- contraindicated <6 weeks postpartum

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11
Q

What is the combines transdermal patch?

A

Evra
released ethinyoestradiol plus the progestogen norelgestromin
• A new patch is applied weekly for 3 consecutive weeks- followed by a patch-free week
• Efficacy, side effects and contraindications are similar to the COCP

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12
Q

What is the combined vaginal ring? (Nuvaring)

A
  • Latex-free Nuvaring releases a daily dose of erthinyloestradiol and etonogestrel to inhibit ovulation
  • It is easily inserted into the vagina by patient- worn for 3 weeks, then removed to allow for a 7-day ring free break and withdrawal bleed- a new ring can then be inserted
  • May be better tolerated than the COC due to lower systemic oestrogenic side effect
  • Ring should not be removed during intercourse- can be removed for a max. 3hrs
  • When used properly, it has similar efficacy to the COCP- it has the same metabolic and coagulation effects as other combined hormonal methods
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13
Q

What is the POP?

A

contains a low dose of norethisterone
must be taken every day without a break and at the same time (±3hrs)
• It makes cervical mucus hostile to sperm- 50% of women inhibit ovulation too
• Failure rates are 1 per 100 woman-years- higher than the combined pill

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14
Q

What are the side effects of the POP?

A
o	Vaginal spotting
o	Weight gain
o	Mastalgia
o	Premenstrual-like symptoms
o	Functional ovarian cyst can occur
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15
Q

When is the POP used?

A

• Particularly suitable for older women and those in whom the combined pill is contraindicated (eg. lactating mothers)
there is no risk of thromboembolism and it can be used in almost all situations where the combined pill is contraindicated

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16
Q

What should you do if a POP is missed?

A
  • If a pill is missed by >3hrs, then another should be taken as soon as possible and condoms used for 2 days
  • POPS are not affected by broad-spectrum antibiotics
  • Cerazette & Cerelle-slightly different preparations- inhibit 95% of ovulatory cycles, more effective and can be taken within a 12hr window
17
Q

What are depot injections?

A

progestogen is released slowly and bypasses portal circulation
mode of action similar to POP, but ovulation is normally also prevented
protect against functional ovarian cysts and ectopic pregnancy
All may be used in breast-feeding women

18
Q

What is depo-provers?

A

contains medroxyprogesterone acetate
administered by IM injection every 3 months
failure rate is <1.0 per 100 woman-years
Can cause irregular bleeding in first few weeks, then amenorrhea may continue after cessation
bone density decreases over first 2-3yrs then stabilises and is regained after stopping, so contraindicated in teenages and women with osteoporosis

19
Q

What is noristerat?

A

IM depot preparation containing norethisterone enantate
similar efficacy as Depo-
Prevera
given every 8 weeks
recommended as a short-term interim contraception

20
Q

What is sayana press?

A

subcutaneous preparation of medroxyprogesterone acetate
licensed for self- administration
provides 13 weeks of cover

21
Q

What is the nexplanon implant?

A

40mm flexible rod containing etonogestrel
inserted into the upper arm subdermally with local anaesthetic
failure rate is <1.0 per 100 woman-years
lasts 3 years
Can cause irregular bleeding in first year
No drop in bone density
Rapid resumption of fertility after removal