Continence Flashcards

1
Q

Normal physiology of continence

A

Continence is maintained by the co-ordinated interaction of the bladder, urethra, pelvic floor muscles and nervous system
-low pressure-high volume
600ml capacity
Desire to void at 250ml
Continent if urethral pressure exceeds bladder pressure

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2
Q

Normal physiology micturition

A

Voluntary relaxation of striated muscle around the urethra

  • > decreased urethral pressure
  • > detruser contraction
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3
Q

The micturition cycle

A

Frontal cortex-> voluntary control
Pontine micturition centre-> coordinates detruser contract in with urethral relaxation
Parasympathetic-> bladder contraction s2-4
-> Ach release -> M3 r’s -> detruser contraction *antimuscarinics=retention
Sympathetic -> bladder filling t11-l2
-> bladder neck and urethra contraction
-> pudendal -> voluntary control of external sphincter
*a adrenergics=retention
*a blockers=stress incontinence

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4
Q

Urge incontinence

A

Detruser over activity with leakage of urine

Involuntary leakage accompanied by urge

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5
Q

Stress incontinence

A

Increased intra abdo pressure and weak pelvic floor muscles/urethral sphincter
Involuntary leakage when laughing, sneezing etc

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6
Q

Mixed incontinence

A

Stress and urge

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7
Q

Functional incontinence

A

Unable to reach the toilet in time

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8
Q

Overflow incontinence

A

Leakage from a full bladder

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9
Q

Reflex incontinence

A

Serious neuro impairment

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10
Q

Transient causes of incontinence

A
Delirium 
Infection
Atrophic vaginitis
Pharmacological agents
Psychiatric disorders 
Excess urine output
Restricted mobility 
Stool impaction
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11
Q

Causes of faecal incontinence

A
Faecal loading with overflow
Lack of fluids and poor diet
Lower GI ca
Haemorrhoids
Sphincter injury 
Dementia
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12
Q

Medications which cause incontinence

A
Alcohol
Caffeine
Sedatives-> less mobile + increased urge 
Antipsychotics-> " +"
A blockers-> relax sphincter
ACEi's -> cough
Ca2+ channel blockers-> retention
Opioids-> retention + constipation
Antihistamines-> "+"
Antidepressants-> "+"
A agonists-> retention
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13
Q

Bladder irritants

A
Carbonated drinks
Tea and coffee
Artificial sweeteners
Corn syrup
Foods high in spice, sugar, acidity
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14
Q

Continence history extras

A
Risk factors
Sexual health 
Obs+gynae
LUTS
Childhood urinary symptoms 
Bowels
Diabetes
Comorbidities
Previous surgery 
Impact on patients life
Fluids, caffeine, smoking 
Bladder control self assessment questionnaire
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15
Q

Continence examination

A
MMSE
Chronic lung disease, CCF
Abdominal masses
Distended bladder
DRE
Vaginal atrophy+ pelvic floor muscles
Neurological, gait, sensation
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16
Q

Simple bedside tests incontinence

A
Freq./volume charts 
Urinalysis
-> glucose 
-> protein 
-> leukocyte + nitrites
-> blood
Mircroscopy
17
Q

Blood tests incontinence

A

FBC- infection
U and E’s- renal function and electrolytes
Glucose - diabetes
Ca- constipation and confusion

18
Q

Imaging incontinence

A

Post void bladder scan
USS abdo - kidneys
CT urography - stones
CT abdo- masses

19
Q

Specialist tests incontinence

A

Urodynamics

Cystoscopy

20
Q

Risk factors for stress incontinence

A
Female 
Weaker bladder outlet
Childbirth
Obesity 
Surgery 
Prostatectomy
21
Q

Risk factors for urge incontinence

A

Idiopathic
Neurogenic
Infective
Obstruction

22
Q

Stress incontinence non medical treatments

A

Patient education
-smoking cessation
-weight reduction
-manage constipation
-decrease alcohol and caffeine
Community continence advisor and physiotherapist
- pelvic floor exercises
-home assessment
Pudendal nerve stimulation -> increase pelvic floor muscles
Vaginal cones -> increase pelvic floor muscles

23
Q

Medical treatment of stress incontinence

A

Duloxetine -> serotonin and noradrenergic reuptake inhibitor
Limited evidence
3rd line

24
Q

Surgical treatment of stress incontinence

A

Mid urethral sling insertion
Colosuspension
Injection of bulking agents in urethra

25
Q

Non pharmacological treatments of overactive bladder

A
Patient education 
- decree fluid intake
- reduce caffeine and alcohol
- weight reduction 
- manage constipation 
Community continence advisor 
Behavioural therapy
-bladder retraining
Pelvic floor exercises
26
Q

Medical treatments for overactive bladder

A

Antimuscarinics -> oxybutynin, foltenidone, donifenacin, trospium -> m3 antagonism-> reduced contractions
B3 adrenoceptor agonists-> help bladder relax
Intra vaginal estrogens
Botulinum toxin injection

27
Q

Surgical treatments of overactive bladder

A

Sacral nerve stimulation

Augmentation

28
Q

Antimuscarinic side effects

A
Blurred vision 
Cognitive impairment
Hallucinations
Dry mouth
Tachycardia
Nausea
Constipation 
Retention
29
Q

Medical treatment of bladder outlet obstruction

A

A blockers -> doxazocin -> reduce smooth muscle tone of the prostate
5 a reductase inhibitors-> finasteride-> reduce prostate volume

30
Q

Epidemiology of incontinence

A
200 million people world wide
2/5 >60 female
30% of older people at home 
50% in care homes
1/4 f 1/10 m