Consolidation Flashcards
You should check kidney function before which cytotoxic drug?
Methotrexate
Which cytotoxic drug is cardiotoxic?
Doxorubicin
Which cytotoxic drug is neurotoxic? What does this cause?
Vincristine
• Neuropathic pain
• Foot drop
• Severe constipation
Which cytotoxic drug can cause liver and kidney toxicity, alongside a skin rash?
Methotrexate (forms crystals)
-kidney function should be tested
Which ADR is characterised by epidermal necrosis causing blisters over 3-30% of the body?
Stevens-Johnson syndrome
• NSAIDS
• Penicillin
• Lamotrigine
Which class of antiviral can cross the blood-brain barrier?
Integrase inhibitors
Which antiviral drug is excreted though the small intestine as well as metabolised by CYP-P450?
Protease inhibitors:
• Darunavir
• Ritanovir
Class I, II and III denote side effect profiles for which classes of drugs? Recall them
Phenothiazines Thioxanthenes I) II) Antimuscarinic III) Extrapyrimidal side effects
Agranulocytosis is a side effect of which antipsychotic?
Clozapine
Weight gain and insulin-resistant diabetes are side effects of which antipsychotics?
Olanzapine
Risperidone
Which class of drugs have the followings affinities: H2: Low H3: High H4: High 5-HT2A: High
2nd Generation Antipsychotics
Which nucleus is stimulated by the suprachiasmatic nucleus and goes on to stimulate the arousal pathways?
Dorsomedial hypothalamic nucleus
What is the tuberomammillary nucleus?
Histaminergic nucleus
What does the ventrolateral preoptic nucleus do?
Releases GABA and galanine to inhibit the arousal pathways
For which cytotoxic drug should you inject intrathecal doses to prevent meningeal leukaemia?
Methotrexate
Which drug class is unique to chronic myeloid leukaemia
Protein kinase inhibitors
What is the precursor amino acid for 5-HT
Tryptophan
Which CPTP drugs are cardiotoxic?
TCAs:
• Amitriptiline
• Trazodone
Anthracyclines:
• Doxorubicin
Galactorrhoea and gynecomastia is caused by what?
Inhibition of the tuberoinfundibular pathway D2 transmission (which acts as prolactin release inhibiting factor) (PRIF)
Which component of the cephalosporin structure makes it mare resistant to beta-lactamases than the penicillins?
The Dihydrothiazine ring
Which type of antibiotic can be used topically for burns victims?
Sulphonamides
• Co-trimoxazole
What drug is typically used for UTIs, RTIs and immunocompromised patients?
Sulphonamides including trimethoprim
Which bacteriocidal drug should never be used on pregnant women or neonates?
Sulphonamides
Penicillins for neonates due to poor removal
Which drugs are malabsorbed with PPI use?
Protease inhibitors
Which drug is malabsorbed with calcium, magnesium and aluminium salts?
Doxycycline
Clarithromycin is particularly effective against?
- H. influenzae
* H. pylori
What are the long-acting NSAIDs?
Celecoxib and Naproxen
Which NSAID can cross the BBB?
Celecoxib
Which NSAID causes CVD?
Celecoxib
Which NSAID does not cause GI side effects?
Celecoxib (as it is COX-2 selective)
Which NSAID is COX-2 selective
Celecoxib
Which NSAID inhibits leukocytes?
Naproxen
Sedation and weight gain is due to what side effect of TCAs?
Anti-H1
Which drugs are used in the treatment of opioid adictions?
Naloxone - Used after some time has passed to reverse the lasting effects of addiction
Methodone - 24hour agonist to stop the effects of withdrawl in cold turkey
Alpha-2 agonists - Many of the cold turkey symptoms are mediated by locus coeruleus overactivity
