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PHTH 565 RHEUMATOLOGY > CONNECTIVE TISSUE DISORDERS > Flashcards

CONNECTIVE TISSUE DISORDERS Flashcards

1
Q

What are connective tissues

A

Any biological tissues with an extensive matrix that

  • provide structure, support, and defense
  • Transport material
  • bind organs together
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2
Q

What do connective tissues consist of

A
  • Cell fibres (collagen or elastic)

- Ground substance (water, fluid, protein)

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3
Q

What are the 6 types of connective tissue

A
  • loose tissue
  • fibrous tissue
  • adipose tissue
  • blood
  • cartilage
  • bone
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4
Q

What is loose tissue composed of? Example of this type of tissue?

A

collagen and elastin

Blood vessels, internal organs

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5
Q

What is fibrous tissue composed of? Example of this type of tissue?

A

mostly collagen, few elastin

Tenson, ligs

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6
Q

Many connective tissue diseases feature…

A

abnormal immune system activity

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7
Q

Is there a genetic component to autoimmune diseases?

A

yes

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8
Q

Is there an environmental component to autoimmune disease

A

yes: Pollution/pesticide infections medications can trigger the onset

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9
Q

Is there a behavioural component to autoimmune disease

A

Yes, smoking or stress can trigger the onset

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10
Q

Lupus is referred to as…

A

“A disease of a thousand faces”

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11
Q

What is the shape of the rash seen in lupus

A

Butterfly-shaped malar rash

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12
Q

What ethnicities does lupus effect most

A
  • Asian
  • African
  • Hispanic
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13
Q

Lupus means what in latin

A

wolf

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14
Q

What does erythro mean in greek

A

red

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15
Q

What does systemic lupus effect

A
  • Skin
  • Lungs
  • Kidney
  • CNS
  • Circulatory system
  • Heart
  • GI system
  • muscle and joint
  • Oral and nasal ulcers
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16
Q

What is needed for a systemic lupus classification

A
  • Malar rash
  • Discoid rash
  • Photosensitivity
  • Oral ulcers
  • non-erosive arthritis
  • Pleuritis or pericarditis
  • Renal disorder
  • Neurological disorder
  • Hematologic disorder
  • Immunologic disorder
  • Positive antinuclear antibody test
17
Q

What are the characteristics of non-erosive arthritis

A
  • Transient
  • Symmetrical
  • Affecting small joints
  • ## Less sever than RA
18
Q

What are the neurologic clinical features of lupus

A 
- Seizures 
= Psychosis 
- Behaviour/personality changes, depression 
- Cognitive dysfunction 
- Stroke 
- Peripheral neuropathy 
- Chorea (abnormal involuntary movement disorder) 
- Transverse myelitis
19
Q

Up to ___% of patients with SLE develop lupus nephritis

A

50%

20
Q

__% of SLE patients require a kidney dyalysis or transplant

A

10%

21
Q

is the renal involvement of lupus normally symptomatic or asymptomatic

A

asymptomatic

22
Q

What is the hallmark clinical feature of renal involvement in SLE

A

proteinuria

23
Q

What is the most frequent cause of disease related death from lupus

A

Renal failure

24
Q

What are some other symptoms of SLE

A
  • Pain
  • Severe fatigue
  • memory loss
  • Depression
25
Q

What is the PT management of Lupus

A
  • Pain management
  • Therapeutic exercise and PA
  • Patient education: energy conservation principles, joint protection principles, sun protection
26
Q

What were the results of PA on those with lupus vs. control groups

A
  • Positive effect on depression
  • positive effect on CR capacity
  • less fatigue
  • no adverse effect on the SLE disease activity
27
Q

What are the two energy conservation principles

A
  • Prioritize - what activities are important to you, what activities can your friends and family help with
  • Plan - Self monitory, balance exercise with rest, eat a well-balanced diet and avoid heavy metals
  • Pace - Balance rest and activity, take breaks, have a routine, get a good nights sleep
  • Posture - Maintain good posture, take standing breaks
28
Q

What are the joint protection principles

A
  1. Respect for pain
  2. Balance activity and rest
  3. Avoid repetitive activities
  4. use larger, stronger joints for activities
  5. Avoid staying in one position for a prolonged period
  6. Maintain good joint alignment
  7. Maintain healthy body weight
  8. maintain good posture
29
Q

What are the main non-pharmacologic intervention in the management of connective tissue disease such as SLE

A
  • Pain control
  • Physical activity
  • Patient education

PHTH 565 RHEUMATOLOGY (7 decks)

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