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block 10 module 2 > Connective tissue disorders > Flashcards

Connective tissue disorders Flashcards

1
Q

Minor form of LE

• Few lesions present • Erythematous alopetic lesion (thick scale in scalp)

A

CCLE

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2
Q

Almost always confined to the skin, no
systemic involvement (internal organs not
involved).

A

Localized CCLE

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3
Q

Auspitz sign in CCLE/CDLE is

A

negative

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4
Q

in SYSTEMIC OR GENERALIZED CCLE/ CDLE lesions are located where

A

above and below the neck

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5
Q

Erythematous swollen plaque onthe malar area that extends to the bridge of thenose

A

Butterfly Rash:

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6
Q

Involves the deep dermis and subcutaneous layer

A

LE/ CDLE PROFUNDUS

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7
Q

Lesions are verrucous, with a rough surface(appear like warts resembling surface of cauliflower or broccoli) /
hyperkeratotic

A

CCLE/ CDLE HYPERTROPIC

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8
Q

histologic features of CCLE Hypertropic

A

mixture of features of LE and lichen planus

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9
Q

Photosensitivity is more pronounced

A

SUBACUTE LUPUS ERYTHEMATOSUS

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10
Q

Widespread, non-scarring;
There can be anemia and defects in renal function but
not of serious nature

A

SUBACUTE LUPUS ERYTHEMATOSUS

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11
Q

Diffuse non-scarring alopecia may occur

A

SUBACUTE LUPUS ERYTHEMATOSUS

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12
Q

subacute LE may mitaken for nummular eczema, what is the difference?

A

lesion in subacute LE, is not pruritic compared to nummular eczema.

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13
Q

common in systemic disease and

is often an indicator of disease activity

A

diffuse alopecia

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14
Q

usually present on the face and other sun-exposed areas.

A

diffuse blotchy erythema

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15
Q

Frequently involves the skin and joints (usual complain is joint pain).

A

SYSTEMIC LUPUS ERYTHEMATOSUS

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16
Q

sudden exposure to cold (put ice on patient’s palm) will result to immediate pallor (sudden vasoconstriction), followed by cyanosis due to reduced blood supply, then erythema (sudden or rebound vasodilation) and
pain on the tips of the extremities

A

Raynaud’s phenomenon:

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17
Q

painful red plaques or lesions on
the base of the fingers in association with exposure to
cold weather

A

SLE Chilblain Lupus

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18
Q

blistering may occasionallyoccur in response to photosensitivity, rarely in childhood. Vesicles and bullae can be seen in exposed areas

A

SLE Bullous of Childhood

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19
Q

When biopsy is done in these lesions (SLE Bullou in childhood),
immunofluorescence studies will show

A

deposition on immunoglobulins (IgG) on the

dermo-epidermal junctions of the skin.

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20
Q

Inflammation of the striated muscle results to progressive proximal muscle weakness

A

DERMATOMYOSITIS (DM)

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21
Q

in radiography of DM what can be seen in the affected proximal muscles?

A

calcium deposits

22
Q

Eruption may spread onto the cheeks and may simulate systemic LE. However, ____ involvement is
characteristic

A

eyelid

23
Q

pathognomonic of the disease DM

A

Heliotrope sign

Gottron’s Sign

24
Q

Specific/distinctive erythema over knuckles w/c may be papular

A

Gottron’s sign

25
Q

T or F both distal and muscles are affected in DM

A

F only the proximal muscles

26
Q

Treatment of DM

A

corticosteroid therapy

27
Q

test to confirm diagnoisis of DM and what i the result

A

muscle biopsy, presence of nodules on the affected area

28
Q

A fibrotic skin disease/excessive deposition of collagen and other connective tissue components leading to
dermal fibrosis

A

scleroderma

29
Q

Subset of scleroderma

A

Calcinosis, Reynaud’s phenomenon, Esophageal dysfunction, Sclerodactyly, Telangiectasia)

30
Q

type of scleroderma where Involvement is not only limited to the skin but also to other organs

A

progressive systemic sclerosis

31
Q

Type of scleroderma: Thickening and induration of the skin in association with eosinophilia and an inflammatory infiltrate (mostly eosinophils) in the subcutaneous fascia and muscles

A

EOSINOPHILIC FASCITIS

32
Q

Only the fingers and toe digits may
present with the dermal changes. There would be
difficulty in flexing the digits. Occurs in poorly controlled
juvenile diabetics.

A

Syndrome of Digital Sclerosis and Joint Contractures:

33
Q

clinical features of scleroderma

A 
reynaud's P
acrosclerosis/sclerodactyly
calcinosis
oral aperture becomes smaller
sausage shaped fingers
34
Q

Chronic non-pitting edema

of fingers/tapering of fingers and thumbs due to atrophy of the pulp of the tips

A

Acroslerosis/ sclerodatyly

35
Q

how can digital ischemia lead to autoamputation

A

it can lead to cutaenous infarction/ulceration/gangrene of fingertips which may lead to autoamputation/

36
Q

worst prognosis of scleroderma

A

lung involvement: pulmo dse w/c may result to terminal fibrosis

37
Q

Sclerodermatous process involving the extremities, sparing the hands and feet

A

EOSINOPHILIC FASCIITIS

38
Q

what is present in the subQ fascia of the muscles in eosinophilic fascitis

A

eosiniphilic infiltrates

39
Q

what distinguishes EF from scleroderma

A

(-) RP and visceral involvement

40
Q

Induration of the skin particularly of the upper back
• Occurs suddenly after a prodrome, particularly in diabetics (some patients develop upper respiratory tract infection, viral or strep illness)

A

SCLERODERMA OF BUSHKE

41
Q

what happens to the sub Q tissue and skin in Scleroderma of bushke

A

SQ is replaced by Collagenous T, kin has a wooden like consistency, shiny app

42
Q

A disorder with a characteristic lichenoid eruption, mucin deposition and paraproteinemia
• Small, dome shaped lichenoid papules arranged in a linear manner

A

LICHEN MYXOEDEMATOSUS (PAPULAR MUCINOSIS)

43
Q

Localized form of scleroderma

A

morphoea

44
Q

T or F morphoea resolves in 1 year

A

F no definite no. of yrs

45
Q

common sites of linear form of morphoea

A

butt and upper part of legs, limb head trunk

46
Q

indented, vertical, colorless, line of skin on the forehead, looking like a sword has struck the area. May be associated with other neurologic conditions such as seizures

A

En coup de sabre

47
Q

type of morphoea which involves the skin only, appears as shiny and sclerotic throughout

A

GENERALIZED FORM

48
Q

Usually patients present with very itchy lesion. It is located in the delicate areas. In females, located in the genital or labial area

A

LICHEN SCLEROSUS ET ATROPHICUS

49
Q

In males, ivory white papules, atrophy, telangiectasia, purpura on foreskin and glans penis

A

BALANITIS SEROTICA OBLITERANS

50
Q

Autoimmune episodic inflammation of cartilaginous tissue, especially on the pinna; recurrences would eventually lead to fibrosis, destruction, and deformity

A

RELAPSING POLYCHONDRITIS

51
Q

why relapsing polychondritis is fatal

A

if trachea is involved

52
Q

relapsing Polychondritis is an autoimmune reaction to

A

native collagen

block 10 module 2 (3 decks)

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