Connective tissue disorders Flashcards
Minor form of LE
• Few lesions present • Erythematous alopetic lesion (thick scale in scalp)
CCLE
Almost always confined to the skin, no
systemic involvement (internal organs not
involved).
Localized CCLE
Auspitz sign in CCLE/CDLE is
negative
in SYSTEMIC OR GENERALIZED CCLE/ CDLE lesions are located where
above and below the neck
Erythematous swollen plaque onthe malar area that extends to the bridge of thenose
Butterfly Rash:
Involves the deep dermis and subcutaneous layer
LE/ CDLE PROFUNDUS
Lesions are verrucous, with a rough surface(appear like warts resembling surface of cauliflower or broccoli) /
hyperkeratotic
CCLE/ CDLE HYPERTROPIC
histologic features of CCLE Hypertropic
mixture of features of LE and lichen planus
Photosensitivity is more pronounced
SUBACUTE LUPUS ERYTHEMATOSUS
Widespread, non-scarring;
There can be anemia and defects in renal function but
not of serious nature
SUBACUTE LUPUS ERYTHEMATOSUS
Diffuse non-scarring alopecia may occur
SUBACUTE LUPUS ERYTHEMATOSUS
subacute LE may mitaken for nummular eczema, what is the difference?
lesion in subacute LE, is not pruritic compared to nummular eczema.
common in systemic disease and
is often an indicator of disease activity
diffuse alopecia
usually present on the face and other sun-exposed areas.
diffuse blotchy erythema
Frequently involves the skin and joints (usual complain is joint pain).
SYSTEMIC LUPUS ERYTHEMATOSUS
sudden exposure to cold (put ice on patient’s palm) will result to immediate pallor (sudden vasoconstriction), followed by cyanosis due to reduced blood supply, then erythema (sudden or rebound vasodilation) and
pain on the tips of the extremities
Raynaud’s phenomenon:
painful red plaques or lesions on
the base of the fingers in association with exposure to
cold weather
SLE Chilblain Lupus
blistering may occasionallyoccur in response to photosensitivity, rarely in childhood. Vesicles and bullae can be seen in exposed areas
SLE Bullous of Childhood
When biopsy is done in these lesions (SLE Bullou in childhood),
immunofluorescence studies will show
deposition on immunoglobulins (IgG) on the
dermo-epidermal junctions of the skin.
Inflammation of the striated muscle results to progressive proximal muscle weakness
DERMATOMYOSITIS (DM)