Connective tissue diseases Flashcards
1
Q
Features of limited scleroderma
A
CREST syndrome
- Calcinosis
- Raynaud’s phenomenon
- Esophageal dysfunction
- Sclerodactyly
- Telangiectasia
2
Q
Features of diffuse scleroderma
A
Affects large area of the skin and one or more internal organs - worse prognosis
3
Q
Pathophysiology of scleroderma
A
T cell-mediated inflammation and collagen deposition
4
Q
3 antibodies positive in slceroderma
A
ANA, anti-scl70 (anti-topoisomerase), anti-centromere
5
Q
3 main causes of death in scleroderma
A
- Pulmonary hypertension
- Pulmonary fibrosis
- Renal crises
6
Q
Presentation of Sjogren’s syndrome
A
Xerostomia, keratoconjunctivitis sicca, vaginal dryness, chronic bronchitis, fatigue, salivary gland enlargement
7
Q
Sjogren’s syndrome is commonly secondary to…
A
RA and SLE
8
Q
2 antibodies positive in Sjogren’s
A
ANA (Ro and La), RF
9
Q
Sjogren patients are at an increased risk of which disease?
A
Non-Hodgkin lymphoma
