Connective Tissue Disease & Systemic Vasculitis

Question 1

What is the gender ratio of SLE?

Answer 1

F:M 9:1

Question 2

Is the peak onset of SLE pre or post 50yrs?

Answer 2

Pre - 15-50yrs

Question 3

What ethnicity is most commonly affected by SLE?

Answer 3

Afro-caribbean (nigga)

Question 4

What are the two main skin manifestation in SLE?

Answer 4

Malar Butterfly rash

Discoid rash

Question 5

What joints are most affected in SLE? (L/S)

Answer 5

Small joints

Question 6

What are two key renal findings in SLE?

Answer 6

Proteinurea +++

Cell casts

Question 7

What is the most specific AI test for SLE?

Answer 7

Anti-Smith (subtype of ANA)

Question 8

What is the most sensitive AI test for SLE?

Answer 8

Anti-DSna

Question 9

What is the onset age for Scleroderma?

Answer 9

30-50yrs

Question 10

What are the two main forms of Scleroderma?

Answer 10

Localised (aka Morphea) and Systemic (aka Systemic Sclerosis/Diffuse/Limited)

Question 11

Does localised scleroderma affect the organs?

Answer 11

No, systemic does

Question 12

What are four serious complications of Scleroderma?

Answer 12

Pulm HTN
Pulm fibrosis
Renal crisis
S Bowel bacterial overgrowth

Question 13

What is the main AI test for Scleroderma?

Answer 13

ANA

Question 14

What are the two key presenting symptoms of Sjorgen’s Syndrome?

Answer 14

Dry eyes
Dry mouth

Also parotid gland enlargement

Question 15

What are some serious complications of Sjorgens syndrome?

Answer 15

Lymphoma
Neuropathy
Pupura
Interstitial lung disease
Renal tubular acidosis

Question 16

What is the main AI test for Sjorgen’s?

Answer 16

ANA

Question 17

Give the 5 diagnostic criteria for GCA. How many are needed?

Answer 17

Age over 50 at onset
Postitive TAB
ESR >50
TA tenderness
New headache 

3

Question 18

What is the main AI test for ANCA Associated Vasculitides?

Answer 18

ANCA

Question 19

What is by far the most common ANCA Associated Vasculitis?

Answer 19

Wegner’s Granulomatosis

Question 20

What is the second most common ANCA AV?

Answer 20

Churg-Stauss Disease

Question 21

What are the two key associated findings in Churg-Strauss?

Answer 21

Asthma

Eosinophilia

Question 22

Where does Wegners often involve?

Answer 22

Upper and lower RT

Caviating lung lesions often seen

Question 23

What is the mild treatment for MSAD?

Answer 23

Hydroxychloroquine

Question 24

What are the three moderate treatments for MSAD?

Answer 24

Azathioprine
Methotrexate
Mycophenolate

Question 25

What are the two severe treatments for MSAD?

Answer 25

Cyclophosphamide

Rituximab